A review of contact dermatitis

Brar, K. S.

doi:10.1016/j.anai.2020.10.003

Cited by 41 publications

(49 citation statements)

References 70 publications

(149 reference statements)

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“…The pathological or symptomatic production in both atopic dermatitis and contact dermatitis is closely related to keratinocytes, immune cells, and nerves. Among them, keratinocytes, which release many different cytokines and chemokines after being stimulated, play a very important role [ 7 , 8 ]. Therefore, compounds that affect the function of keratinocytes will have therapeutic potential.…”

Section: Introductionmentioning

confidence: 99%

Effect of Neferine on DNCB-Induced Atopic Dermatitis in HaCaT Cells and BALB/c Mice

Yang

Hung

et al. 2021

IJMS

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Atopic dermatitis (AD) is a chronic and persistent inflammatory skin disease characterized by eczematous lesions and itching, and it has become a serious health problem. However, the common clinical treatments provide limited relief and are accompanied by adverse effects. Therefore, there is a need to develop novel and effective therapies to treat AD. Neferine is a small molecule compound isolated from the green embryo of the mature seeds of lotus (Nelumbo nucifera). It has a bisbenzylisoquinoline alkaloid structure. Relevant studies have shown that neferine has many pharmacological and biological activities, including anti-inflammatory, anti-thrombotic, and anti-diabetic activities. However, there are very few studies on neferine in the skin, especially the related effects on inflammatory skin diseases. In this study, we proved that it has the potential to be used in the treatment of atopic dermatitis. Through in vitro studies, we found that neferine inhibited the expression of cytokines and chemokines in TNF-α/IFN-γ-stimulated human keratinocyte (HaCaT) cells, and it reduced the phosphorylation of MAPK and the NF-κB signaling pathway. Through in vivo experiments, we used 2,4-dinitrochlorobenzene (DNCB) to induce atopic dermatitis-like skin inflammation in a mouse model. Our results show that neferine significantly decreased the skin barrier damage, scratching responses, and epidermal hyperplasia induced by DNCB. It significantly decreased transepidermal water loss (TEWL), erythema, blood flow, and ear thickness and increased surface skin hydration. Moreover, it also inhibited the expression of cytokines and the activation of signaling pathways. These results indicate that neferine has good potential as an alternative medicine for the treatment of atopic dermatitis or other skin-related inflammatory diseases.

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Section: Introductionmentioning

confidence: 99%

Effect of Neferine on DNCB-Induced Atopic Dermatitis in HaCaT Cells and BALB/c Mice

Yang

Hung

et al. 2021

IJMS

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“…The first phase begins with sensitization with an allergen or hapten that is presented by dendritic cells (DCs) to T cells, which then become effector T cells. In the elicitation phase when the allergen is reintroduced, these allergen-specific T cells then produce dermatitis, which develops around 72 hours after re-exposure to the allergen (Brar, 2021;Garzorz-Stark et al, 2018).…”

Section: Discussion Of Incorrect Answersmentioning

confidence: 99%

SnapshotDx Quiz: October 2021

Cho

Chong

2021

Journal of Investigative Dermatology

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“…This elements is ubiquitous in metals. It is increasing in sensitivity and is the most common allergen found worldwide (2). It is also frequently used in eyeglass frames, metal buckles and fasteners, coins, tools, braces, and toys (1,2).…”

Section: F O R P U B L I C a T I O Nmentioning

confidence: 99%

“…It is increasing in sensitivity and is the most common allergen found worldwide (2). It is also frequently used in eyeglass frames, metal buckles and fasteners, coins, tools, braces, and toys (1,2). Thus, especially concerning nickel, patch testing is imperative to ensure early diagnosis of this specific allergy and adequate intervention (3).…”

Section: F O R P U B L I C a T I O Nmentioning

confidence: 99%

“…Allergic contact dermatitis (ACD) is a delayed type IV hypersensitivity reaction that occurs in susceptible individuals with previous exposure to subsequent sensitization (1). Additionally, an overlap of these two types of dermatitis may occur (2). ACD affects 20% of individuals regardless of age in general population, and, when added to cases of irritant contact dermatitis, the sum of the two is responsible for more than 90% of occupational skin lesions (3).…”

Section: Introductionmentioning

confidence: 99%

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Prospective study of consecutive patch testing in patients with contact dermatitis using an adapted Latin American baseline series

Belluco

Giavina‐Bianchi

Belluco

et al. 2023

Eur Ann Allergy Clin Immunol

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Background: Contact dermatitis is a disease characterized by pruritic skin lesions with high prevalence rates. The patch test is an instrument to evaluate contact allergies. Current data on characteristics of the affected population and studies about patch testing using adequate baseline series are needed. Objectives:To describe the clinical and epidemiological characteristics of a population with suspected contact dermatitis who underwent to a patch testing using an adapted Latin American baseline series in the departments of allergy and dermatology of a referral center in Brasília, Brazil, between March and December 2020.Methods: Observational, descriptive and analytical clinical study with prospective data collection was performed in consecutively evaluated patients at a referral center. The results of 208 participants who underwent patch testing using an adapted Latin American baseline series containing 40 allergens were analyzed, and the prevalence of contact allergies was compared with data from the literature. Pearson's chi-square test was used to calculate the odds ratio and respective 95% confidence interval for qualitative variables. Quantitative variables were compared using the Mann-Whitney U test. The four most prevalent allergens were entered into multiple binary logistic regression models as response variables to identify the main explanatory variables associated with these allergies. The significance of the regression parameters was tested using the Wald statistical test. Results:The mean age of participants was 42.6 years. A total of 69.7% had one or more positive tests. Among those with positive tests, 82.8% were women (OR = 1.371; p = 0.398). The hands were the most commonly affected site at 43%. An occupational history was detected in 19.2%. The most common allergen was nickel sulfate (32.2%), followed by sodium tetrachloropalladate (19.7%), fragrance mix I (15.4%), and methylisothiazolinone (13.5%). In multivariate logistic regression models, nickel was significantly related to female sex (p < 0.05), as well as palladium (p < 0.05). Fragrance mix I was related to a family history of allergy (p < 0.05). On the other hand, methylisothiazolinone was statistically significantly related to face (p < 0.05) and hand (p < 0.001) lesions. Conclusion:This study demonstrated a detailed profile of a population with suspected allergic contact dermatitis. Our patch test results, using an adapted Latin American baseline series, represent a significant update of this important diagnostic tool.

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A review of contact dermatitis

Cited by 41 publications

References 70 publications

Effect of Neferine on DNCB-Induced Atopic Dermatitis in HaCaT Cells and BALB/c Mice

Effect of Neferine on DNCB-Induced Atopic Dermatitis in HaCaT Cells and BALB/c Mice

SnapshotDx Quiz: October 2021

Prospective study of consecutive patch testing in patients with contact dermatitis using an adapted Latin American baseline series

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