Health communication scholars are often interested in drawing causal inferences between communication variables, health behaviors, and health outcomes. Experiments offer powerful tools for understanding causal relationships in health communication research but may or may not be appropriate given the interests of the researcher and the nature of the communication phenomena of interest. This entry begins by distinguishing between true experiments (which involve random assignment) and quasi‐experiments (which do not). It continues with a discussion of ethical issues to consider when deciding whether or not to use experiments for health communication research. It describes a variety of potential uses of experiments to answer important questions in health communication, including formative research to inform decisions about a campaign, evaluation research to test the effectiveness of a communication intervention, research to understand the relative contribution of communication within larger health interventions, and research to test and refine theories relevant to health communication. It concludes with reflection on a variety of contemporary issues in the use of experiments for health communication research, including difficulty in capturing the complexity of the networked digital information environment, diversity in research participants, replicability and reproducibility, open science, and preregistration.