A Review of Cognitive Impairments in Dementia with Lewy Bodies Relative to Alzheimer's Disease and Parkinson's Disease with Dementia

Metzler‐Baddeley, Claudia

doi:10.1016/s0010-9452(08)70489-1

Cited by 171 publications

(131 citation statements)

References 94 publications

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“…Instead, we used the well-known and common tool MMSE in order to find a relatively solid platform when calculating survival as earlier studies have been contradictive. To compare cognitive decline between AD and DLB patients over time is complicated since their neuropsychological profiles differ, with particularly more visual-perception and attention difficulties in DLB [36,37]. To find a test that considers the differences yet adequately captures changes in cognition in both groups is a challenge.…”

Section: Discussionmentioning

confidence: 99%

Differences in Survival between Patients with Dementia with Lewy Bodies and Patients with Alzheimer's Disease - Measured from a Fixed Cognitive Level

Stubendorff

Hansson

Minthon

et al. 2011

Dement Geriatr Cogn Disord

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Introduction: The aim of this study was to compare survival in patients with Alzheimer's disease (AD) and patients with dementia with Lewy bodies (DLB). Since anamnestic and retrospective information about disease duration are unreliable variables, we measured survival from a fixed cognitive level. Methods: Survival time was measured from the reported disease onset, from the time of diagnosis, from Mini-Mental State Examination (MMSE) 20 ± 1, and from MMSE 17 ± 1. Results: Survival time was significantly shorter in the DLB group compared to the AD group both from the time of diagnosis and from the cognitive levels of 20 and 17 on the MMSE. There was no difference in survival when measured from the reported disease onset. Discussion: Our findings indicate that DLB patients have a more malignant clinical course. Our method of investigating survival in a cognitively homogenous population may gain scientific power. Reliable methods to predict survival and the clinical course are of great value for patients, caregivers, doctors, and society.

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Section: Discussionmentioning

confidence: 99%

Differences in Survival between Patients with Dementia with Lewy Bodies and Patients with Alzheimer's Disease - Measured from a Fixed Cognitive Level

Stubendorff

Hansson

Minthon

et al. 2011

Dement Geriatr Cogn Disord

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“…These features are associated with the occurrence of other commonly observed neuropsychiatric DLB symptoms, including visual hallucinations (Collerton et al ., 2005). Whilst there is a significant overlap between DLB and Alzheimer's disease (AD) in terms of symptoms, in the early stages of DLB, individuals typically display more severe visuoperceptual, attentional and executive function deficits, with relative preservation of memory, compared with similarly impaired AD patients (Metzler‐Baddeley, 2007). The manner in which the cholinergic pathways are affected in DLB compared with other dementias may explain these differences.…”

Section: Introductionmentioning

confidence: 99%

Structural grey matter changes in the substantia innominata in Alzheimer's disease and dementia with Lewy bodies: a DARTEL‐VBM study

Colloby

Elder

Rabee

et al. 2016

Int J Geriat Psychiatry

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ObjectivesSeveral cholinergic nuclei, and in particular the nucleus basalis of Meynert, are localised to the substantia innominata in the basal forebrain. These nuclei provide major cholinergic innervation to the cerebral cortex and hippocampus, and have an essential role in cognitive function. The aim of this study was to investigate volumetric grey matter (GM) changes in the substantia innominata from structural T1 images in Alzheimer's disease (AD), dementia with Lewy bodies (DLB) and healthy older participants using voxel‐based morphometry.MethodsParticipants (41 DLB, 47 AD and 39 controls) underwent 3 T T1 magnetic resonance imaging and cognitive assessments. Voxel‐based morphometry analysis used SPM8 with a substantia innominata brain mask to define the subspace for voxel GM analyses. Group differences, and selected behavioural and clinical correlates, were assessed.ResultsCompared with that in controls, bilateral GM loss in the substantia innominata was apparent in both AD and DLB. Relative to controls, significant bilateral GM loss in the substantia innominata was observed in DLB and AD. In DLB, significant associations were also observed between substantia innominata GM volume loss, and the levels of cognitive impairment and severity of cognitive fluctuations.ConclusionsRelative to that controls, atrophy of the substantia innominata was apparent in DLB and AD, and is associated with specific clinical manifestations in DLB. © 2016 The Authors. International Journal of Geriatric Psychiatry Published by John Wiley & Sons Ltd.

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“…Yet cognitive impairment occurs in most cases with advanced PD. More importantly, altered cortical function can be detected in some individuals before the appearance of motor symptoms, and cortical dysfunction is common in classic Parkinsonism when appropriately examined (12). Recent neuroimaging approaches have supported the involvement of the cere-bral cortex with disease progression (13)(14)(15).…”

Section: Introductionmentioning

confidence: 99%

Severe Alterations in Lipid Composition of Frontal Cortex Lipid Rafts from Parkinson’s Disease and Incidental Parkinson’s Disease

Fabelo

Martín

Santpere

et al. 2011

Mol Med

303

253

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Lipid rafts are cholesterol-and sphingomyelin-enriched microdomains that provide a highly saturated and viscous physicochemical microenvironment to promote protein-lipid and protein-protein interactions. We purified lipid rafts from human frontal cortex from normal, early motor stages of Parkinson's disease (PD) and incidental Parkinson's disease (iPD) subjects and analyzed their lipid composition. We observed that lipid rafts from PD and iPD cortices exhibit dramatic reductions in their contents of n-3 and n-6 long-chain polyunsaturated fatty acids, especially docosahexaenoic acid (22:6-n3) and arachidonic acid (20:4n-6). Also, saturated fatty acids (16:0 and 18:0) were significantly higher than in control brains. Paralleling these findings, unsaturation and peroxidability indices were considerably reduced in PD and iPD lipid rafts. Lipid classes were also affected in PD and iPD lipid rafts. Thus, phosphatidylserine and phosphatidylinositol were increased in PD and iPD, whereas cerebrosides and sulfatides and plasmalogen levels were considerably diminished. Our data pinpoint a dramatic increase in lipid raft order due to the aberrant biochemical structure in PD and iPD and indicate that these abnormalities of lipid rafts in the frontal cortex occur at early stages of PD pathology. The findings correlate with abnormal lipid raft signaling and cognitive decline observed during the development of these neurodegenerative disorders.

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A Review of Cognitive Impairments in Dementia with Lewy Bodies Relative to Alzheimer's Disease and Parkinson's Disease with Dementia

Cited by 171 publications

References 94 publications

Differences in Survival between Patients with Dementia with Lewy Bodies and Patients with Alzheimer's Disease - Measured from a Fixed Cognitive Level

Differences in Survival between Patients with Dementia with Lewy Bodies and Patients with Alzheimer's Disease - Measured from a Fixed Cognitive Level

Structural grey matter changes in the substantia innominata in Alzheimer's disease and dementia with Lewy bodies: a DARTEL‐VBM study

Severe Alterations in Lipid Composition of Frontal Cortex Lipid Rafts from Parkinson’s Disease and Incidental Parkinson’s Disease

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