A review of clinical treatment considerations of donepezil in severe Alzheimer's disease

Adlimoghaddam, Aida; Neuendorff, Melanie; Roy, Banibrata; Albensi, Benedict C.

doi:10.1111/cns.13035

Cited by 86 publications

(63 citation statements)

References 45 publications

(78 reference statements)

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“…Aβ could also lead to blunted cerebrovascular responses . PMVs were reported to participate in Aβ‐induced neurovascular dysfunction through CD36 mediated oxidative stress.…”

Section: Pvm Alterations In Diseased Brainmentioning

confidence: 99%

“…Aβ could also lead to blunted cerebrovascular responses. 71,72 PMVs were reported to participate in Aβ-induced neurovascular and increased number of PVMs in HIVE was observed decades ago. 74 Using simian immunodeficiency virus (SIV)-infected rhesus macaque models, multiples studies reported the existence of SIV RNA and proteins in PVMs but not microglia.…”

Section: Cerebrovascular Diseases and Risk Factorsmentioning

confidence: 99%

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Brain perivascular macrophages: Recent advances and implications in health and diseases

2019

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Brain perivascular macrophages (PVMs) belong to a distinct population of brain‐resident myeloid cells located within the perivascular space surrounding arterioles and venules. Their characterization depends on the combination of anatomical localization, phagocytic capacity, and molecular markers. Under physiological status, they provide structural and functional support for maintaining brain homeostasis, including facilitation of blood‐brain barrier integrity and lymphatic drainage, and exertion of immune functions such as phagocytosis and antigen presentation. Increasing evidence also implicates their specific roles in diseased brain, ranging from cerebrovascular diseases, Aβ pathologies, infections, and autoimmunity. Collectively, PVMs are key components of the brain‐resident immune system, actively participate in a broad‐spectrum of processes in normal and diseased status. Details of the processes are largely underexplored. Targeting PVMs would lead to new insights and be a promising strategy for a broad array of human diseases.

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“…Aβ could also lead to blunted cerebrovascular responses . PMVs were reported to participate in Aβ‐induced neurovascular dysfunction through CD36 mediated oxidative stress.…”

Section: Pvm Alterations In Diseased Brainmentioning

confidence: 99%

Section: Cerebrovascular Diseases and Risk Factorsmentioning

confidence: 99%

Brain perivascular macrophages: Recent advances and implications in health and diseases

2019

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“…The most common form of dementia is accounted for by Alzheimer s disease (AD) that includes between 50% and 75% of the cases of dementia with a doubling of its prevalence every five years after the age of 65 years [2,3]. AD is a neurodegenerative disease afflicting more than 45 million people worldwide with approximately 1% of those in their 60s and up to 8% of those above the age of 85.…”

Section: Introductionmentioning

confidence: 99%

“…AD is a neurodegenerative disease afflicting more than 45 million people worldwide with approximately 1% of those in their 60s and up to 8% of those above the age of 85. Although AD is prevalently sporadic, mutations in the three genes-amyloid precursor protein (APP), presenilin 1 (PSEN1), and presenilin 2 (PSEN2)-cause a rare (<0.5%) familial form of AD (fAD) that develops at an earlier age (between 30 and 50 years) than the sporadic case [2,3]. The remaining forms of the disease are due to vascular dementia (VaD), mixed Alzheimer s and VaD, dementia with Lewy bodies, and frontotemporal dementia [2,3].…”

Section: Introductionmentioning

confidence: 99%

The Role of Macrophage Migration Inhibitory Factor in Alzheimer′s Disease: Conventionally Pathogenetic or Unconventionally Protective?

et al. 2020

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Recent preclinical and clinical observations have offered relevant insights on the etiopathogenesis of late onset Alzheimer′s disease (AD) and upregulated immunoinflammatory events have been described as underlying mechanisms involved in the development of AD. Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine produced by several cells of the innate and adaptive immune system, as well as non-immune cells. In the present review, we highlight experimental, genetic, and clinical studies on MIF in rodent models of AD and AD patients, and we discuss emerging therapeutic opportunities for tailored modulation of the activity of MIF, that may potentially be applied to AD patients. Dismantling the exact role of MIF and its receptors in AD may offer novel diagnostic and therapeutic opportunities in AD.

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“…There is no cure for AD and treatments are largely supportive. Most treatments consist of pharmacotherapy (cholinesterase inhibitors, NMDA antagonists) and psychosocial therapy (environmental manipulation, family support, prevention of additional medical comorbidities) (5,(20)(21)(22)(23)(24).…”

Section: Alzheimer's and Canine Cognitive Dysfunction Alzheimer's Dismentioning

confidence: 99%

Canine Models of Inherited Musculoskeletal and Neurodegenerative Diseases

et al. 2020

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Mouse models of human disease remain the bread and butter of modern biology and therapeutic discovery. Nonetheless, more often than not mouse models do not reproduce the pathophysiology of the human conditions they are designed to mimic. Naturally occurring large animal models have predominantly been found in companion animals or livestock because of their emotional or economic value to modern society and, unlike mice, often recapitulate the human disease state. In particular, numerous models have been discovered in dogs and have a fundamental role in bridging proof of concept studies in mice to human clinical trials. The present article is a review that highlights current canine models of human diseases, including Alzheimer's disease, degenerative myelopathy, neuronal ceroid lipofuscinosis, globoid cell leukodystrophy, Duchenne muscular dystrophy, mucopolysaccharidosis, and fucosidosis. The goal of the review is to discuss canine and human neurodegenerative pathophysiologic similarities, introduce the animal models, and shed light on the ability of canine models to facilitate current and future treatment trials.

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A review of clinical treatment considerations of donepezil in severe Alzheimer's disease

Abstract: Clinicians must weigh benefits against adverse events when determining the course of therapy, as recommendations for cholinesterase inhibitors in advanced AD remain unclear and vary with different guidelines.

Cited by 86 publications

References 45 publications

Brain perivascular macrophages: Recent advances and implications in health and diseases

Brain perivascular macrophages: Recent advances and implications in health and diseases

The Role of Macrophage Migration Inhibitory Factor in Alzheimer′s Disease: Conventionally Pathogenetic or Unconventionally Protective?

Canine Models of Inherited Musculoskeletal and Neurodegenerative Diseases

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