A review of clinical studies involving pregnant women registered in the Clinical Trials Registry of India

Karekar, Sonali Rajiv; Pooja, Sharma; Marathe, Padmaja A

doi:10.4103/picr.picr_157_18

Cited by 6 publications

(2 citation statements)

References 7 publications

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“…In agreement, Camellia sinensis products are among the herbal extracts used to enhance immune system function for which the safety should be determined in pregnancy [ 216 ]. It has recently been pointed out that pregnant women are under-represented in clinical studies, and there is a need for more evidence with respect to drug and nutraceuticals safety and pharmacokinetics [ 217 ]. Although, in animal models, some bioactive phytochemicals—including resveratrol—had positive effects on embryo/fetal development and maternal health, however others—such as epicatechin gallate and curcumin—had adverse effects [ 198 ] and caution in the consumption of soy food and phytoestrogens during pregnancy has been suggested [ 198 ].…”

Section: Mechanisms Of the Mediterranean Diet Componentsmentioning

confidence: 99%

Mediterranean Diet for the Prevention of Gestational Diabetes in the Covid-19 Era: Implications of Il-6 In Diabesity

Fedullo¹,

Schiattarella

Morlando

et al. 2021

IJMS

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The aim of this review is to highlight the influence of the Mediterranean Diet (MedDiet) on Gestational Diabetes Mellitus (GDM) and Gestational Weight Gain (GWG) during the COVID-19 pandemic era and the specific role of interleukin (IL)-6 in diabesity. It is known that diabetes, high body mass index, high glycated hemoglobin and raised serum IL-6 levels are predictive of poor outcomes in coronavirus disease 2019 (COVID-19). The immunopathological mechanisms of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection include rising levels of several cytokines and in particular IL-6. The latter is associated with hyperglycemia and insulin resistance and could be useful for predicting the development of GDM. Rich in omega-3 polyunsaturated fatty acids, vitamins, and minerals, MedDiet improves the immune system and could modulate IL-6, C reactive protein and Nuclear Factor (NF)-κB. Moreover, polyphenols could modulate microbiota composition, inhibit the NF-κB pathway, lower IL-6, and upregulate antioxidant enzymes. Finally, adhering to the MedDiet prior to and during pregnancy could have a protective effect, reducing GWG and the risk of GDM, as well as improving the immune response to viral infections such as COVID-19.

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Section: Mechanisms Of the Mediterranean Diet Componentsmentioning

confidence: 99%

Mediterranean Diet for the Prevention of Gestational Diabetes in the Covid-19 Era: Implications of Il-6 In Diabesity

Fedullo¹,

Schiattarella

Morlando

et al. 2021

IJMS

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show abstract

“…Women have historically been underrepresented in medical research. For example, drug trials to date have been conducted almost exclusively in young men 12 , and a recent review of clinical trials (including nutraceutical) in India found that less than 2% included pregnant women 13 . This is problematic because there is likely to be sexual dimorphism in the physiology, metabolism, and related toxicity and efficacy of supplements and drugs.…”

Section: Introductionmentioning

confidence: 99%

Protocol for meta-research on the evidence informing micronutrient dietary reference intakes for pregnant and lactating women

Klatt

Rahnavard

et al. 2020

Gates Open Res

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Nutrient reference values are important parameters that guide nutrition and public health work globally. Micronutrient requirements during the peri-conception period are generally increased, which is essential in ensuring maternal, fetal, and neonatal health. Nevertheless, the current dietary reference intakes (DRIs) may be limited in terms of the methods used and the populations included, particularly the DRIs for pregnancy and lactation. In this proposed review, we will examine the methods (rigor of design, utilization of molecular methods, and presence of modern methods) and the population (inclusion of women, and in particular, pregnant and lactating people) in the studies used to inform the current DRIs. We will apply meta-science methods to this review, which involves formally reviewing the current evidence, and identifying opportunities to improve how we fund, perform, evaluate, and incorporate nutrition science into public health programs for better outcomes.

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Recruitment of pregnant women to randomised trials of COVID 19 treatments, and pharmaceutical treatments received outside such trials: A research article

Green

Young

Oberman

et al. 2022

European Journal of Obstetrics & Gynecology and Reproductiv

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A review of clinical studies involving pregnant women registered in the Clinical Trials Registry of India

Cited by 6 publications

References 7 publications

Mediterranean Diet for the Prevention of Gestational Diabetes in the Covid-19 Era: Implications of Il-6 In Diabesity

Mediterranean Diet for the Prevention of Gestational Diabetes in the Covid-19 Era: Implications of Il-6 In Diabesity

Protocol for meta-research on the evidence informing micronutrient dietary reference intakes for pregnant and lactating women

Recruitment of pregnant women to randomised trials of COVID 19 treatments, and pharmaceutical treatments received outside such trials: A research article

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