1997
DOI: 10.1159/000474527
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A Review of Clinical Studies of Bropirimine Immunotherapy of Carcinoma in situ of the Bladder and Upper Urinary Tract

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Cited by 12 publications
(2 citation statements)
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“…Loxoribine shows anti-viral and anti-tumor activity in murine animal models since it activates NK cells, B cells and induces various cytokines (Pope et al, 1994;Smee et al, 1990). Bropirimine is an orally active immunomodulator that induces IFN-a and is used for immunotherapy of carcinoma in situ of the bladder and upper urinary tract (Sarosdy, 1997). Overall the synthetic nucleoside analogs are universal compounds for activating TLR7 or TLR8 and may prove useful in the future to modulate immune responses for fighting viral infection or tumors in humans.…”
Section: Tlr7 and Tlr8 Ligandsmentioning
confidence: 99%
“…Loxoribine shows anti-viral and anti-tumor activity in murine animal models since it activates NK cells, B cells and induces various cytokines (Pope et al, 1994;Smee et al, 1990). Bropirimine is an orally active immunomodulator that induces IFN-a and is used for immunotherapy of carcinoma in situ of the bladder and upper urinary tract (Sarosdy, 1997). Overall the synthetic nucleoside analogs are universal compounds for activating TLR7 or TLR8 and may prove useful in the future to modulate immune responses for fighting viral infection or tumors in humans.…”
Section: Tlr7 and Tlr8 Ligandsmentioning
confidence: 99%
“…This compound exhibits anti-tumor and anti-viral activity via activation of NK and B cells to induce multiple cytokines [ 105 , 106 , 107 ]. Bropirimine is an aryl pyrimidinone analogue, an antineoplastic compound that induces IFN-α and is used for treatment of carcinoma [ 108 , 109 ]. The mechanism of action of bropirimine is likely to be direct anti-tumor effect rather than cytokine mediated anti-tumor activity [ 110 ].…”
Section: Nucleic Acid Sensing Tlr Agonists and Their Therapeutic Amentioning
confidence: 99%