A review of clinical and experimental observations about antidepressant actions and side effects produced by Hypericum perforatum extracts

Rodríguez‐Landa, Juan Francisco; Contreras, Carlos M.

doi:10.1078/0944-7113-00340

Cited by 88 publications

(69 citation statements)

References 86 publications

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“…Because of the increasing public interest in this herb and its many intriguing biological activities, extensive analysis has been applied toward identifying the chemical composition of Hp in order to determine which compounds may be responsible for its antidepressant (1)(2)(3)(4)(5), antibacterial (1,2), cytotoxic (8,9), and antiviral (10-13) activities. However, most studies conducted have only evaluated the biological activities exhibited by ethanol and methanol extractions prepared from Hp plant material and the individual compounds identified within these fractions.…”

Section: Introductionmentioning

confidence: 99%

“…The efficacy of SJW as an antidepressant has been extensively studied along with its safety (1)(2)(3)(4)(5)(6). The clinical and animal trials conducted thus far demonstrate Hp extracts to be just as effective as tricyclic antidepressants with fewer shortterm side effects, but recent evidence of drug-herb interactions involving the hepatic cytochrome P450 enzyme system may be one of several adverse reactions to this herb that need to be elucidated before it can be deemed a safe form of alternative medicine (1)(2)(3)(4)(5)7).…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of the Light-Sensitive Cytotoxicity of Hypericum perforatum Extracts, Fractions, and Pure Compounds

Schmitt

Liu

Murphy

et al. 2006

J. Agric. Food Chem.

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Hypericum perforatum (Hp) is known for possessing antidepressant and antiviral activities. Despite its use as an alternative to conventional antidepressants, the identification of the cytotoxic chemicals derived from this herb is incomplete. In this study, the cytotoxicity of Hp extracts prepared in solvents ranging in polarity, fractions of one extract, and purified compounds were examined in three cell lines. All extracts exhibited significant cytotoxicity; those prepared in ethanol (no hyperforin, 3.6 μM hypericin, and 134.6 μM flavonoids) showed between 7.7 and 77.4% cell survival (p < 0.0001 and 0.01), whereas the chloroform and hexane extracts (hyperforin, hypericin, and flavonoids not detected) showed approximately 9.0 (p < 0.0001) and 4.0% (p < 0.0001) survival. Light-sensitive toxicity was observed primarily with the ethanol extracts sequentially extracted following removal of material extracted in either chloroform or hexane. The absence of light-sensitive toxicity with the Hp extracts suggests that the hypericins were not playing a prominent role in the toxicity of the extracts.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Evaluation of the Light-Sensitive Cytotoxicity of Hypericum perforatum Extracts, Fractions, and Pure Compounds

Schmitt

Liu

Murphy

et al. 2006

J. Agric. Food Chem.

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“…H. perforatum has been traditionally used as an aromatic, expectorant, anxiolytic, sedative and anti-inflammatory to treat bladder complaints, chronic catarrh, colds, diarrhoea, jaundice, rheumatism, menopause, worms and nervous depression [16,39]. H. perforatum has been widely tested in vivo and in vitro for a variety of pharmacological effects such as antibacterial, anti-inflammatory [40], wound-healing [41,42], antitumoral [43], antiviral [44], inhibition of dopamine and norepinephrine reuptake [45], reduction of neuropathic pain [46] and treatment of mild-to-moderate depression [47,48] among others. Hydroalcoholic extracts of H. perforatum contain naphtodianthrones, flavonoids, phenylpropanes, phloroglucinols, proanthocyanidins secondary, tannins [40] but it is known that the activities mentioned before are mainly mediated by a single or a combination of hypericin, pseudohypericin and/or hyperforin (Fig.…”

Section: H Perforatum (Hypericaceae) St John's Wortmentioning

confidence: 99%

“…Hypericin is considered a potential new tool for the photodynamic therapy of cancer [44]. Hyperforin is known to be the key contributing metabolite for antidepressant activity and the main metabolite responsible for the antibacterial activity [40,47]. Other plants now known to have therapeutic properties and used in drug development (Table 1) were evident in the Anglo-Saxon formulations and with closer inspection, the texts could provide further insights into additional pharmacological compounds from native British plants.…”

Section: H Perforatum (Hypericaceae) St John's Wortmentioning

confidence: 99%

Anglo-Saxon pharmacopoeia revisited: a potential treasure in drug discovery

Watkins

Pendry

Corcoran

et al. 2011

Drug Discovery Today

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Modern translations provide a new opportunity to revisit the Anglo-Saxon medicinal texts, a valuable resource for discovering and developing novel compounds from native British flora. Previous pharmacological studies of 16 th and 17 th century medicinal plants reported in the Anglo-Saxon medical texts, suggest some were effective and led to the identification and isolation of new natural compounds such as matricin from Achillea millefolium L., a prodrug that yields chamazulene carboxylic acid, a natural profen.New insights through multidisciplinary projects could further explore the manuscript content for the discovery of metabolites with potential pharmacological applications.

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“…178 St John's wort causes photosensitivity and could augment photosensitization caused by other drugs. 179 St John's wort has also been shown to inhibit apoptosis caused by some anticancer drugs such as paclitaxel. 180 This botanical also negated the benefits of atorvastatin on total cholesterol and low-density lipoprotein levels in humans.…”

Section: St John's Wortmentioning

confidence: 99%

Drug—Botanical Interactions: A Review of the Laboratory, Animal, and Human Data for 8 Common Botanicals

2009

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Many Americans use complementary and alternative medicine (CAM) to prevent or alleviate common illnesses, and these medicines are commonly used by individuals with cancer. These medicines or botanicals share the same metabolic and transport proteins, including cytochrome P450 enzymes (CYP), glucuronosyltransferases (UGTs), and P-glycoprotein (Pgp), with over-thecounter and prescription medicines increasing the likelihood of drug-botanical interactions. This review provides a brief description of the different proteins, such as CYPs, UGTs, and Pgp. The potential effects of drug-botanical interactions on the pharmacokinetics and pharmacodynamics of the drug or botanical and a summary of the more common models used to study drug metabolism are described. The remaining portion of this review summarizes the data extracted from several laboratory, animal, and clinical studies that describe the metabolism, transport, and potential interactions of 8 selected botanicals. The 8 botanicals include black cohosh, Echinacea, garlic, Gingko biloba, green tea, kava, milk thistle, and St John's wort; these botanicals are among some of the more common botanicals taken by individuals with cancer. These examples are included to demonstrate how to interpret the different studies and how to use these data to predict the likelihood of a clinically significant drug-botanical interaction.

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A review of clinical and experimental observations about antidepressant actions and side effects produced by Hypericum perforatum extracts

Cited by 88 publications

References 86 publications

Evaluation of the Light-Sensitive Cytotoxicity of Hypericum perforatum Extracts, Fractions, and Pure Compounds

Evaluation of the Light-Sensitive Cytotoxicity of Hypericum perforatum Extracts, Fractions, and Pure Compounds

Anglo-Saxon pharmacopoeia revisited: a potential treasure in drug discovery

Drug—Botanical Interactions: A Review of the Laboratory, Animal, and Human Data for 8 Common Botanicals

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