A review of cardiovascular effects and underlying mechanisms of legacy and emerging per- and polyfluoroalkyl substances (PFAS)

Wen, Zeng-Jin; Wei, Yi-Jing; Zhang, Yifei; Zhang, Yinfeng

doi:10.1007/s00204-023-03477-5

Cited by 27 publications

(4 citation statements)

References 226 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Microplastics and their degradation products may also harbour toxic chemicals arising from additives during production, or chemicals absorbed from the environment. A contaminant of concern harboured by plastics are per- and polyfluoroalkyl substances (PFAS) which have been shown to induce immune, cardiovascular, endocrine, and hepatic dysfunction and increase the risk of developing malignancies 21,22 . Contact lenses have been shown to be a source of microplastic exposure, and a recent study showed that contact lens usage was associated with elevated serum PFAS levels among young adults 14,23 .…”

Section: Discussionmentioning

confidence: 99%

Microplastics Identified in Commercial Over-the-counter Lubricant Eyedrops

Jaeger,

Burke,

et al. 2024

Preprint

View full text Add to dashboard Cite

Purpose There is increasing evidence that microplastics exert harmful effects on human health and on the ocular surface. Recent studies have highlighted the presence of ocular surface exposure to microplastics via shedding from contact lenses. This study aims to investigate if microplastic particles are present in commonly used eyedrops in single-use plastic vials. Design Experimental study. Methods Nine commonly used commercial tear-replacement solutions available without a doctor's prescription were tested (Brands A-I). All brands of eyedrops were analysed visually using light microscopy and the number of microplastic particles were manually counted. Brands A-F were further analysed using the 8700 Agilent Laser Direct Infrared (LDIR) chemical imaging system to identify the microplastic compositions. Results All eyedrops analysed contained microplastics. The number of microplastic particles identified using light microscopy ranged between 15 (Brand E) to >18,000 (Brand F). In total, nine types of microplastics were identified with LDIR - an average of 14 polyethylene, 8 polypropylene, 1 polystyrene, 2 polyvinylchloride, 21 polyethylene terephthalate, 1 polycarbonate, 19 polymethylmethacrylate, 23 polyamide and 22 polyurethane per millilitre of eyedrop were identified. Conclusions This is the first study that identified microplastics in commercial tear-replacement solutions. These particles may have been derived from secondary degradation of the plastic vials (polyethylene) during production, transportation, or storage, and represent a major source of exposure to the ocular surface, especially among patients who require chronic instillation of eyedrops.

show abstract

Section: Discussionmentioning

confidence: 99%

Microplastics Identified in Commercial Over-the-counter Lubricant Eyedrops

Jaeger,

Burke,

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…In recent decades, there has been a growing public concern about the detrimental impact of environmental endocrine-disrupting chemicals on human health. These chemicals encompass phthalates, along with novel alternatives like di(2-ethylhexyl) phthalate (DEHP) and 1,2-cyclohexane dicarboxylic acid diisononyl ester (DINCH) (Uhl et al, 2023;Wen et al, 2023;Yao et al, 2023). Phthalate esters are extensively utilized in the production of a variety of wall coverings, toys, packaging, vehicles, furnishings, and medical uses (Wittassek et al, 2011;Hammel et al, 2019;Wang and Kannan, 2023).…”

Section: Introductionmentioning

confidence: 99%

Exposure to phthalates and their alternatives in relation to biomarkers of inflammation and oxidative stress in adults: evidence from NHANES 2017–2018

Jin,

Cui,

et al. 2023

Environ Sci Pollut Res

View full text Add to dashboard Cite

Phthalates and their alternatives are considered signi cant environmental risk factors that potentially in uence in ammation and oxidative stress. However, their impact on biomarkers of in ammation and oxidative stress was inconsistent. This study aimed to explore the associations between phthalates and high-sensitivity C-reactive protein (hsCRP), gamma-glutamyl transferase (GGT), and white blood cell (WBC) counts, employing both univariate exposure and multivariate co-exposure models. For this analysis, a total of 1619 individuals aged 18 years and above, sourced from the National Health and Nutrition Examination Survey (NHANES) conducted between 2017 and 2018, were selected as subjects. We explored the associations between hsCRP, GGT, and WBC counts and eighteen different phthalate metabolites. Multiple linear regression analysis revealed signi cant associations between hsCRP and two speci c metabolites: MCNP (β = 0.060, P = 0.034) and MEHP (β = -0.054, P = 0.049). We observed negative correlations of MCOP, MCPP, MHBP, and MONP with GGT (β = -0.036, P = 0.027; β = -0.045, P = 0.019; β = -0.046, P = 0.023; β = -0.053, P = 0.001, respectively). Conversely, MEHHP and MEHTP exhibited positive correlations with GGT (β = 0.048, P = 0.011; β = 0.029, P = 0.009). Furthermore, MECPTP and MEHTP showed positive correlations with WBC (β = 0.011, P = 0.026; β = 0.017, P = 0.001). Notably, we identi ed a non-linear relationship between phthalates and in ammation and oxidative stress markers.The Bayesian kernel machine regression (BKMR) analysis demonstrated a negative joint effect of the phthalates mixture on GGT, particularly at lower concentrations. The BKMR model also found that MEOHP and MHiBP were negatively associated with GGT. In contrast, MEHHP showed a signi cant positive association with GGT. Moderating effect analysis suggested that increased dietary in ammatory index (DII), income-to-poverty ratio (PIR), age, BMI, and less physical activity strengthened the association between phthalates and in ammation and oxidative stress. These ndings contribute to a deeper understanding of the relationships between phthalates and in ammation and oxidative stress.

show abstract

Section: Introductionmentioning

confidence: 99%

Exposure to phthalates and their alternatives in relation to biomarkers of inflammation and oxidative stress in adults: Evidence from NHANES 2017-2018

Jin,

Cui,

et al. 2023

Preprint

View full text Add to dashboard Cite

Phthalates and their alternatives are considered significant environmental risk factors that potentially influence inflammation and oxidative stress. However, their impact on biomarkers of inflammation and oxidative stress was inconsistent. This study aimed to explore the associations between phthalates and high-sensitivity C-reactive protein (hsCRP), gamma-glutamyl transferase (GGT), and white blood cell (WBC) counts, employing both univariate exposure and multivariate co-exposure models. For this analysis, a total of 1619 individuals aged 18 years and above, sourced from the National Health and Nutrition Examination Survey (NHANES) conducted between 2017 and 2018, were selected as subjects. We explored the associations between hsCRP, GGT, and WBC counts and eighteen different phthalate metabolites. Multiple linear regression analysis revealed significant associations between hsCRP and two specific metabolites: MCNP (β = 0.060, P = 0.034) and MEHP (β = -0.054, P = 0.049). We observed negative correlations of MCOP, MCPP, MHBP, and MONP with GGT (β = -0.036, P = 0.027; β = -0.045, P = 0.019; β = -0.046, P = 0.023; β = -0.053, P = 0.001, respectively). Conversely, MEHHP and MEHTP exhibited positive correlations with GGT (β = 0.048, P = 0.011; β = 0.029, P = 0.009). Furthermore, MECPTP and MEHTP showed positive correlations with WBC (β = 0.011, P = 0.026; β = 0.017, P = 0.001). Notably, we identified a non-linear relationship between phthalates and inflammation and oxidative stress markers. The Bayesian kernel machine regression (BKMR) analysis demonstrated a negative joint effect of the phthalates mixture on GGT, particularly at lower concentrations. The BKMR model also found that MEOHP and MHiBP were negatively associated with GGT. In contrast, MEHHP showed a significant positive association with GGT. Moderating effect analysis suggested that increased dietary inflammatory index (DII), income-to-poverty ratio (PIR), age, BMI, and less physical activity strengthened the association between phthalates and inflammation and oxidative stress. These findings contribute to a deeper understanding of the relationships between phthalates and inflammation and oxidative stress.

show abstract

A review of cardiovascular effects and underlying mechanisms of legacy and emerging per- and polyfluoroalkyl substances (PFAS)

Cited by 27 publications

References 226 publications

Microplastics Identified in Commercial Over-the-counter Lubricant Eyedrops

Microplastics Identified in Commercial Over-the-counter Lubricant Eyedrops

Exposure to phthalates and their alternatives in relation to biomarkers of inflammation and oxidative stress in adults: evidence from NHANES 2017–2018

Exposure to phthalates and their alternatives in relation to biomarkers of inflammation and oxidative stress in adults: Evidence from NHANES 2017-2018

Contact Info

Product

Resources

About