A Review of Cardiac Autonomic Measures: Considerations for Examination of Physiological Response in Children with Autism Spectrum Disorder

Benevides, Teal; Lane, Shelly J.

doi:10.1007/s10803-013-1971-z

Cited by 108 publications

(117 citation statements)

References 59 publications

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“…The current investigation contributes to the growing literature on the biopsychosocial correlates of ASD in adolescence. The majority of previous work focusing on children has found reduced RSA in response to social stressors in ASD (Benevides and Lane 2015). Although we did not find the hypothesized difference in variability between groups during the stressor, there was an overall group effect of reduced RSA in the ASD group, providing preliminary evidence that reduced PNS activity in children with ASD persists into adolescence.…”

Section: Discussionmentioning

confidence: 99%

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Physiological Response to Social Evaluative Threat in Adolescents with Autism Spectrum Disorder

Edmiston

Jones

Corbett

2016

J Autism Dev Disord

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The Trier Social Stress Test (TSST) was employed to study response to social evaluative threat in male adolescents with Autism Spectrum Disorder (ASD, n = 21) and typical development (n = 13). Participants wore a mobile electrocardiogram to collect heart rate data. There were significant group effects on respiratory sinus arrhythmia (RSA), a measure of parasympathetic nervous system function, with lower values in ASD (F = 4.97). Bivariate correlations also showed a significant relationship between parent reports of social problems and RSA response to the TSST (r = −0.586). These findings suggest that autonomic dysregulation may contribute to social deficits in adolescents with ASD.

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Section: Discussionmentioning

confidence: 99%

“…There is an emerging ASD literature regarding ANS effects on cardiac function in pre-pubertal children; although these studies have been somewhat mixed (for review see Benevides and Lane 2015). This may be due in part to differences in the type of stressor or challenge used.…”

Section: Introductionmentioning

confidence: 99%

Physiological Response to Social Evaluative Threat in Adolescents with Autism Spectrum Disorder

Edmiston

Jones

Corbett

2016

J Autism Dev Disord

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“…Differences in regulatory systems that underlie social approach and avoidance behavior, including alterations in the ANS, could be related to observable differences in social behavior in ASD (Benevides and Lane, 2013). Impedance cardiography may be particularly beneficial in assessing ANS reactivity in ASD; it is non-invasive and can act as an objective measure of reactivity to a variety of stimuli (Schaaf, Benevides, Leiby, & Sendecki, 2015).…”

Section: Introductionmentioning

confidence: 99%

Altered pre-ejection period response to social evaluative threat in adolescents with autism spectrum disorder

Edmiston

Muscatello

Corbett

2017

Research in Autism Spectrum Disorders

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Introduction The autonomic nervous system (ANS) is involved in regulating social behavior; Autism Spectrum Disorder (ASD) is characterized by alterations in social behavior and reduced physiological response to threat. We hypothesized that adolescents with ASD would show reduced ANS response to social threat. Methods Eighteen males with ASD and thirteen males with typical development (TD), ages 12 to 17, completed a social threat paradigm while wearing an impedance cardiography apparatus. We calculated pre-ejection period (PEP) and tested for between-group differences in PEP response to social threat. We also conducted correlation analyses between PEP change scores and clinical symptom scales. Results There was an effect of diagnosis on change in PEP from baseline to the onset of social threat (F=7.60, p=0.01), with greater changes in PEP in TD compared to ASD. PEP change score and the Social Communication Questionnaire (r=0.634, p=0.005) and the ADHD Problems Subscale of the Child Behavior Checklist (r=0.568, p=0.014) were correlated. Conclusions These findings suggest reduced arousal in response to social threat in ASD, with preliminary evidence that reduced sympathetic activation is associated with increased social behavior symptoms.

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“…The ANS may also contribute to cognitive, affective, and behavioral responses in children [1]. Several models have linked to possible changes in the development of ANS function to autism.…”

Section: Introductionmentioning

confidence: 99%

“…Third, medications used in ASD can affect HR and HRV. Finally, children with ASD show reduced responsiveness of HRV during challenging tasks [1]. …”

Section: Introductionmentioning

confidence: 99%

Heart rate variability during sleep in children with autism spectrum disorder

et al. 2016

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Purpose Autonomic dysfunction has been reported in autism spectrum disorder (ASD). Less is known about autonomic function during sleep in ASD. The objective of this study is to provide insight into the autonomic cardiovascular control during different sleep stages in ASD. We hypothesized that patients with ASD have lower vagal and higher sympathetic modulation with elevated heart rate (HR), as compared to typical developing children (TD). Methods We studied 21 children with ASD and 23 TD children during overnight polysomnography. Heart rate and spectral parameters were calculated for each vigilance stage during sleep. Data from the first four sleep cycles were used to avoid possible effects of different individual sleep lengths and sleep cycle structures. Linear regression models were applied to study the effects of age and diagnosis (ASD and TD). Results In both groups, HR decreased during non-REM sleep and increased during REM sleep. However, HR was significantly higher in stages N2, N3 and REM sleep in the ASD group. Children with ASD showed less high frequency (HF) modulation during N3 and REM sleep. LF/HF ratio was higher during REM. Heart rate decreases with age at the same level in ASD and in TD. We found an age effect in LF in REM different in ASD and TD. Conclusion Our findings suggest possible deficits in vagal influence to the heart during sleep, especially during REM sleep. Children with ASD may have higher sympathetic dominance during sleep but rather due to decreased vagal influence.

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A Review of Cardiac Autonomic Measures: Considerations for Examination of Physiological Response in Children with Autism Spectrum Disorder

Cited by 108 publications

References 59 publications

Physiological Response to Social Evaluative Threat in Adolescents with Autism Spectrum Disorder

Physiological Response to Social Evaluative Threat in Adolescents with Autism Spectrum Disorder

Altered pre-ejection period response to social evaluative threat in adolescents with autism spectrum disorder

Heart rate variability during sleep in children with autism spectrum disorder

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