A Review of Biological Applications of Transition Metal Complexes Incorporating N-acylhydrazones

Abstract

In view of the crucial importance of the bioactivities of N-acylhydrazone derivatives and their corresponding metal complexes, N-acylhydrazones have recently attracted the attention of researchers in the chemical, biological and pharmaceutical fields. This review aims to describe N-acylhydrazone complexes involving transition metal ions such as copper, chromium, manganese, iron, cobalt, nickel and zinc, and to investigate their properties and possible applications, in various domains. It also tries to examine and determine the most promising applications of a number of transition metal complexes incorporating N-acylhydrazones in the areas of biology, medicine, and pharmacology.

Dinuclear oxidovanadium complexes with dihydrazone ligands derived from diethyl 2,6-dimethylpyridine-3,5-dicarboxylate obtained from Hantzsch reaction; crystal structure and catalytic activity

“…5 Furthermore, their complexes are usually very stable under catalytic conditions. 6 Transition metal complexes of hydrazones have numerous applications in a variety of fields, including biochemistry, 7 optical and magnetic materials, 8,9 catalysts, 10,11 and so on.…”

Unexpected structural complexity of d-block metallosupramolecular architectures within the benzimidazole-phenoxo ligand scaffold for crystal engineering aspects

“…These include e.g. photoresponsiveness 32 , 33 , stimuli-reponsive magnetism 29 , 34 , biological properties 35 , 36 , sensing, preparative organic chemistry 37 and so on 33 . Whereas the hydrazone counterpart can solely serve as the connector of molecular tectons, we became specifically interested in the structure/properties relations of the benzimidazole (‘benz’) 38 and phenoxide (‘phenox’) based architectures.…”