A review of axonal transport of metals

Arvidson, Björn

doi:10.1016/0300-483x(94)90107-4

Cited by 69 publications

(23 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Despite the limited epidemiologic data addressing this question, there is growing experimental evidence that ultrafine (UFP; \0.1 lm in diameter) and fine (\2.5 lm in diameter) particles in ambient air can reach the brain and cause brain lesions and inflammatory responses in animals [19,20]. More broadly, it has been hypothesized that ambient pollutants may impact the brain through several mechanisms: (1) direct translocation of particulate matter from the sinuses to the brain along the olfactory nerves, (2) passage of particulate matter or soluble metals through the alveolar wall of the lungs into the systemic circulation, and across the blood brain barrier, or (3) the induction of a systemic inflammatory response in the lungs that results in the formation of reactive oxygen species in distant tissues including the brain [20][21][22][23]. Both DNA damage and chronic inflammation are conditions associated with increased cancer risk.…”

Section: Introductionmentioning

confidence: 99%

Ambient air pollution and brain cancer mortality

McKean‐Cowdin

Calle

Peters

et al. 2009

Cancer Causes Control

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 99%

Ambient air pollution and brain cancer mortality

McKean‐Cowdin

Calle

Peters

et al. 2009

Cancer Causes Control

View full text Add to dashboard Cite

show abstract

“…Neurotoxicity induced by heavy metals is well-documented in humans and experimental animals (1). Both Cd 2+ and Pb 2+ reach the central nervous system either by crossing the bloodbrain barrier or via retrograde axonal transport (2,3).…”

mentioning

confidence: 99%

Lead (Pb2+) and cadmium (Cd2+) inhibit the dipsogenic action of central beta-adrenergic stimulation by isoproterenol

Fregoneze

Marinho²,

Soares³

et al. 1997

Braz J Med Biol Res

View full text Add to dashboard Cite

We have previously demonstrated that acute third ventricle injections of both Pb 2+ and Cd 2+ impair the dipsogenic response elicited by three different situations: dehydration and central cholinergic or angiotensinergic stimulation. ß-Adrenergic activation is part of the multifactorial integrated systems operating in drinking behavior control in the central nervous system. In the present study acute third ventricle injections of Pb 2+ (3, 30 and 300 pmol/rat) or Cd 2+ (0.3, 3 and 30 pmol/ rat) blocked the dipsogenic response induced by third ventricle injections of isoproterenol (ISO; 160 nmol/rat) in a dose-dependent manner. Normohydrated animals receiving ISO + NaAc (sodium acetate) or saline (controls) displayed a high water intake after 120 min (ISO + saline = 5.78 ± 0.54 ml/100 g; ISO + NaAc = 6.00 ± 0.6 ml/100 g). After the same period, animals receiving ISO but pretreated with PbAc at the highest dose employed (300 pmol/rat) drank 0.78 ± 0.23 ml/100 g while those receiving ISO and pretreated with the highest dose of CdCl 2 (30 pmol/rat) presented a water intake of 0.7 ± 0.30 ml/100 g. Third ventricle injections of CdCl 2 (3 nmol/rat) or PbAc (3 nmol/rat) did not modify food intake in rats deprived of food for 24 h. Thus, general central nervous system depression explaining the antidipsogenic action of the metals can be safely excluded. It is concluded that both Pb 2+ and Cd 2+ inhibit water intake induced by central ß-adrenergic stimulation. Received April 11, 1996 Accepted December 17, 1996 Key wordsHuman exposure to heavy metals such as cadmium (Cd 2+ ) and lead (Pb 2+ ) may bring about several adverse reactions. Neurotoxicity induced by heavy metals is well-documented in humans and experimental animals (1). Both Cd 2+ and Pb 2+ reach the central nervous system either by crossing the bloodbrain barrier or via retrograde axonal transport (2,3).The presence of heavy metals in the central nervous system disrupts the functional integrity of several neurotransmitter pathways. Many independent reports confirm alterations in brain monoaminergic receptors and uptake after Pb 2+ (4) and Cd 2+ (5,6) intoxication.We have recently used a new approach to study the acute actions of heavy metals on

show abstract

“…To this day, the potential absorption of metal NPs by means of this mechanism has been poorly investgated; nevertheless, it represents a matter of concern, since the CNS may be exposed to the neurotoxic effects of xenobiotics in professional and/or environmental scenarios [14][15][16].…”

Section: Introductionmentioning

confidence: 99%