A review of autoimmune diseases associated with cancer

Tai, Patricia; Yu, Edward; Joseph, Kurian; Miale, Thomas D.

doi:10.2741/e73

Cited by 7 publications

(5 citation statements)

References 11 publications

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“…A recent study by Shiokawa et al reported that the risk of developing various cancers was highest during the first year after AIP diagnosis, and that most patients diagnosed with cancer prior to the diagnosis of AIP did not experience relapse of AIP after the successful treatment of the cancer 40 . From these data, they speculate that AIP may be a manifestation of paraneoplastic syndrome, which is a rare condition triggered by an altered immune system response to a neoplasm 41 . In our cohort, 3 PaCs were found during the mean follow-up period of 94.7 months (range, 31-186 months), indicating that the process of carcinogenesis had not yet occurred in the pancreas at the time of the diagnosis of type 1 AIP, and that our cases were not associated with paraneoplastic syndrome .…”

Section: Comparison In Incidence Of Pac Between Type 1 Aip Patients Amentioning

confidence: 99%

Relationship between autoimmune pancreatitis and pancreatic cancer: A single-center experience

et al. 2014

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Section: Comparison In Incidence Of Pac Between Type 1 Aip Patients Amentioning

confidence: 99%

Relationship between autoimmune pancreatitis and pancreatic cancer: A single-center experience

et al. 2014

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“…The paraneoplastic autoimmune process may affect the nervous system, cutaneous tissue, musculoskeletal system, hematopoietic cells, endocrine system or kidneys . Immune‐mediated hematological PNS include AIHA, anti‐FVIII antibodies, antiphospholipid antibodies, autoimmune thrombocytopenia, and others .…”

Section: Discussionmentioning

confidence: 99%

Paraneoplastic Evans syndrome in a patient with adenocarcinoma of the lung: A case report

Wang

et al. 2016

Thoracic Cancer

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We present a rare case of newly diagnosed Evans syndrome associated with lung papillary adenocarcinoma in which the patient showed prompt restoration of blood cell count and long‐lasting complete remission of Evans syndrome after lung cancer resection. Detailed investigation led to a diagnosis of Evans syndrome. In the first year of the disease, left lower lung papillary adenocarcinoma was diagnosed. Pulmonary lobectomy and three courses of chemotherapy were performed. Six months after the initial visit, the primary lung cancer and the autoimmune diseases appeared to be well controlled. We hypothesized that our patient's initial presentation of hematological manifestation was a paraneoplastic phenomenon associated to her underlying malignancy. This rare case report illustrates the unique relationship between primary lung cancer and the development of paraneoplastic Evans syndrome.

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“…The literature showed that a history of autoimmune disease increases the risk of cancer, not specifically hematologic-originating malignancies [16]. This is not a causal relationship as treatments for lupus and rheumatoid arthritis also are implicated.…”

Section: Discussion and Treatmentmentioning

confidence: 99%

Orthopaedic Case of the Month: A 62-year-old Woman With Neck Pain and Neurologic Findings

Papaliodis

Roberts

DiCaprio

et al. 2013

Clinical Orthopaedics &Amp; Related Research

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A 62-year-old woman presented with 3 months of intractable neck pain with recent onset of upper extremity weakness and paresthesias. She reported no fever, weight loss, fatigue, or generalized malaise. She had subtle complaints of hand dexterity loss but said she had no problems with balance, and no bladder or bowel complaints. Analgesics and antispasmodic medications did not relieve her pain. Her medical history was significant for hypertension, hyperlipidemia, diabetes mellitus Type II, multiple sclerosis, depression, anxiety, obesity, and hypothyroidism. There was no history of antecedent trauma, previous rheumatologic phenomena, recurrent infections, or bleeding dyscrasia. There was no family history of cancer or congenital skeletal abnormalities. Review of systems was otherwise negative.On physical examination, the patient was afebrile with normal vital signs. She was oriented to person, time, and environment. The head was normocephalic and sclerae were anicteric. ROM of the neck was normal, and she had no pain with movement of her neck. She had no palpable lymphadenopathy. There was no tenderness to palpation of the posterior shoulder musculature. Cranial nerves II through XII were grossly intact; signs of hypocalcemia including Chvostek's sign and Trousseau's signs were not elicited. Abdominal examination was benign without hepatomegaly or splenomegaly. Neurologically, the patient had some mild weakness with wrist extension and finger extension on the left (C 4/5) but an otherwise normal examination with intact sensation and motor function in her lower extremities. Reflexes were brisk and symmetric. Hoffmann's sign was positive but symmetric suggesting an upper motor neuron lesion, but there was no elicitable clonus. Babinski response was plantar indicating a normal neurologic response in the lower extremities.Laboratory examination showed a white blood cell count of 7.8, hematocrit of 37.3, mean corpuscular volume (MCV) of 84, with a normal differential (54% segmented neutrophils, 9% band neutrophils, 33% lymphocytes), normal chemistries including a serum calcium of 8.9 mg/dL, and an erythrocyte sedimentation rate of 100 mm/hour.We obtained CT scans of the cervical spine (Fig. 1), head, and chest, abdomen, and pelvis, MR images of the spine (Fig. 2), and a whole-body bone scan. Imaging InterpretationThe CT scan of the cervical spine showed a prevertebral lesion extending from C7 to T2 and a permeative pattern of bone destruction within the C7 vertebra (Fig.

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A review of autoimmune diseases associated with cancer

Cited by 7 publications

References 11 publications

Relationship between autoimmune pancreatitis and pancreatic cancer: A single-center experience

Relationship between autoimmune pancreatitis and pancreatic cancer: A single-center experience

Paraneoplastic Evans syndrome in a patient with adenocarcinoma of the lung: A case report

Orthopaedic Case of the Month: A 62-year-old Woman With Neck Pain and Neurologic Findings

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