A review of arsenic exposure and lung cancer

Wei, Shuhui; Zhang, Hong; Tao, Shasha

doi:10.1039/c8tx00298c

Cited by 62 publications

(28 citation statements)

References 93 publications

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“…This means that almost no oAs was converted into iAs under the experimental condition. It is consistent with previous study (Wei et al, 2019). The result further showed that uAs may bind to proteins in the form of iAs.…”

Section: Discussionsupporting

confidence: 94%

Arsenic Species in Cordyceps sinensis and Its Potential Health Risks

Liu

Han

et al. 2019

Front. Pharmacol.

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High arsenic residues make Cordyceps sinensis a concern in China. Arsenic toxicity is related to its species. Many studies have evaluated the toxicity of total arsenic, but few have studied its species. In this study, the species of arsenic in C. sinensis and its potential health risk were investigated. SEC-HPLC-ICP-MS was used to analysis of arsenic in C. sinensis and unknown arsenic (uAs) was discovered. Additionally, arsenic in C. sinensis was mainly found in alkali-soluble proteins. The trend of arsenic transformation indicated that unknown arsenic in C. sinensis may be converted into free inorganic arsenic, which enhanced toxicity. The result of risk assessment indicated that there were potential health risks of uAs. Hereon, we proposed recommendations for the use of C. sinensis and regulatory recommendations for arsenic standards. This study contributed to the toxicity reveal, safety evaluation, and risk assessment of arsenic in C. sinensis.

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Section: Discussionsupporting

confidence: 94%

Arsenic Species in Cordyceps sinensis and Its Potential Health Risks

Liu

Han

et al. 2019

Front. Pharmacol.

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“…The DDR system encompasses eight pathways: MMR, BER, checkpoint factors, Fanconi anemia, HRR, NER; nonhomologous end-joining; and DNA translesion synthesis. (Faita et al 2013;Lau et al 2013;Rao et al 2017;Wei et al 2019) Skin Cancer 5-FUl, 5% imiquimod 2,3-dimercapto-l-propanesulfate (Guha Mazumder et al 2001;Khandpur and Sharma 2003;Yu et al 2006)…”

Section: Dna Damage and Repair Biomarkers In Cancer Therapymentioning

confidence: 99%

Unboxing the molecular modalities of mutagens in cancer

Kumari

Sharma

Advani

et al. 2021

Environ Sci Pollut Res

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Graphical abstract The etiology of the majority of human cancers is associated with a myriad of environmental causes, including physical, chemical, and biological factors. DNA damage induced by such mutagens is the initial step in the process of carcinogenesis resulting in the accumulation of mutations. Mutational events are considered the major triggers for introducing genetic and epigenetic insults such as DNA crosslinks, single- and double-strand DNA breaks, formation of DNA adducts, mismatched bases, modification in histones, DNA methylation, and microRNA alterations. However, DNA repair mechanisms are devoted to protect the DNA to ensure genetic stability, any aberrations in these calibrated mechanisms provoke cancer occurrence. Comprehensive knowledge of the type of mutagens and carcinogens and the influence of these agents in DNA damage and cancer induction is crucial to develop rational anticancer strategies. This review delineated the molecular mechanism of DNA damage and the repair pathways to provide a deep understanding of the molecular basis of mutagenicity and carcinogenicity. A relationship between DNA adduct formation and cancer incidence has also been summarized. The mechanistic basis of inflammatory response and oxidative damage triggered by mutagens in tumorigenesis has also been highlighted. We elucidated the interesting interplay between DNA damage response and immune system mechanisms. We addressed the current understanding of DNA repair targeted therapies and DNA damaging chemotherapeutic agents for cancer treatment and discussed how antiviral agents, anti-inflammatory drugs, and immunotherapeutic agents combined with traditional approaches lay the foundations for future cancer therapies.

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“…This exposes the big problem of how these toxins are incorporated into the food chain, causing a phenomenon of bioaccumulation and biomagnification so that the final amount to which a human is exposed by consumption of food and water contaminated with the metal is greater, and with them, there would be a greater risk of developing cancer due to arsenic [98,6]. Prolonged exposure to high concentrations of arsenic is linked to a greater risk for cancer of the bladder, skin, lung, digestive pathways, liver, kidney and lymphatic and hematopoietic cancers [98,109,110,6,17,18].…”

Section: Environmental Toxins Foods and Cancermentioning

confidence: 99%

Cancer prevention programmes in Mexico: are we doing enough?

Padilla-Raygoza

Monroy-Torres

Sandoval-Salazar

et al. 2020

ecancer

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Cancer has increased in all the countries of the world and Mexico is no exception. The recognised risk factors for the main types of cancer are reviewed and searched through the Mexican government web pages and cancer prevention programmes to tackle the risk factors in the population. The Mexican government, a member of the World Health Organization, shows that the main approach is an early diagnosis rather than prevention, forgetting that an ounce of prevention is better than a pound of cure. Effective public programmes should be promoted to reduce preventable risk factors in the population (smoking, nutrition, obesity, diet, environmental toxicity, sedentary lifestyle) and control the non-preventable factors (genetics) if we really want to control the incidence of different types of cancer.

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A review of arsenic exposure and lung cancer

Abstract: As a well-established human carcinogen, arsenic has increased the risk of lung cancer over the past decades.

Cited by 62 publications

References 93 publications

Arsenic Species in Cordyceps sinensis and Its Potential Health Risks

Arsenic Species in Cordyceps sinensis and Its Potential Health Risks

Unboxing the molecular modalities of mutagens in cancer

Cancer prevention programmes in Mexico: are we doing enough?

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