A Review of Applications of Solid-State Nuclear Magnetic Resonance (ssNMR) for the Analysis of Cyclodextrin-Including Systems

Mazurek, Anna; Szeleszczuk, Łukasz

doi:10.3390/ijms24043648

Cited by 12 publications

(10 citation statements)

References 102 publications

(75 reference statements)

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“…Multidimensional ssNMR spectroscopy at the magic angle spinning (MAS) regime is a powerful technique to study the molecular structure and interactions for guest–host types of complexes at the atomic level . In this study, we utilized 1D 1 H– 13 C cross-polarization (CP) and 19 F Hahn-echo (HE) ssNMR experiments to study HCFU, FU, and HBA complexation with γCD-K-5.…”

Section: Resultsmentioning

confidence: 99%

Cyclodextrin Metal–Organic Frameworks as a Drug Delivery System for Selected Active Pharmaceutical Ingredients

Kru̅kle-Be̅rziṇa,

Lends,

Boguszewska-Czubara

2024

ACS Omega

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The cyclodextrin-based metal−organic frameworks (CD MOFs) are a suitable molecular platform for drug delivery systems of various active pharmaceutical ingredients (APIs). The low toxicity and cost-efficient synthesis make CD MOFs an attractive host for the encapsulation of APIs. In this study, we created a model system based on γCD-K MOFs with widely used drugs carmofur (HCFU), 5fluorouracil (5-FU), and salicylic acid (HBA) to study host−guest encapsulation methods using different crystallization protocols. The host−guest complexes of API:CD MOF in an in-depth study were investigated by liquid chromatography−mass spectrometry (LC-MS), differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), and 19 F-and 13 C-detected solid-state NMR spectroscopy (ssNMR). These techniques confirmed the structure and interaction sites within the encapsulation product in the host−guest complex. We also evaluated the toxicity and biocompatibility of the API:CD MOF complex using in vitro and in vivo methods. The cytotoxicity, hepatotoxicity, and neurotoxicity were established with cell lines of fibroblasts (BJ), human liver cell line (HepG2), and human oligodendrocytic cells (MO3.13). Then, Danio rerio was used as an in vivo experimental model of ecotoxicity. The results showed the choice of γCD-K-5 as the most protective and safe option for drug encapsulation to decrease its toxicity level against normal cells.

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Section: Resultsmentioning

confidence: 99%

Cyclodextrin Metal–Organic Frameworks as a Drug Delivery System for Selected Active Pharmaceutical Ingredients

Kru̅kle-Be̅rziṇa,

Lends,

Boguszewska-Czubara

2024

ACS Omega

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“…CDs are cyclic structures consisting of multiple glucose units linked together [ 18 , 19 , 20 , 21 , 22 ]. Depending on the number of linked unit structures, generally six, seven or eight units, they are classified as α-, β-, and γ-cyclodextrins, respectively ( Figure 1 and Table 1 ).…”

Section: Current Status Of Cyclodextrinsmentioning

confidence: 99%

Application of Cyclodextrin for Cancer Immunotherapy

Wei

2023

Molecules

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Tumor immunotherapy, compared with other treatment strategies, has the notable advantage of a long-term therapeutic effect for preventing metastasis and the recurrence of tumors, thus holding great potential for the future of advanced tumor therapy. However, due to the poor water solubility of immune modulators and immune escape properties of tumor cells, the treatment efficiency of immunotherapy is usually significantly reduced. Cyclodextrin (CD) has been repeatedly highlighted to be probably one of the most investigated building units for cancer therapy due to its elegant integration of an internal hydrophobic hollow cavity and an external hydrophilic outer surface. The application of CD for immunotherapy provides new opportunities for overcoming the aforementioned obstacles. However, there are few published reviews, to our knowledge, summarizing the use of CD for cancer immunotherapy. For this purpose, this paper provides a comprehensive summary on the application of CD for immunotherapy with an emphasis on the role, function, and reported strategies of CD in mediating immunotherapy. This review summarizes the research progress made in using CD for tumor immunotherapy, which will facilitate the generation of various CD-based immunotherapeutic delivery systems with superior anticancer efficacy.

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“…In addition to native (non-substituted) CDs, the food industry, medicines, cosmetics, biomedicine, and textiles have all found significant usage for these derivatives [23] (Table 1). Large-ring cyclodextrins (LR-CDs), which range in size from nine to more than several hundred units, are also being researched and employed, although the three CDs that are most frequently used are those that contain six, seven, and eight glucose subunits [22]. In addition to native (non-substituted) CDs, the food industry, medicines, cosmetics, biomedicine, and textiles have all found significant usage for these derivatives [23] (Table 1).…”

Section: Cyclodextrins As Taste-masking Agentsmentioning

confidence: 99%

Review of Applications of Cyclodextrins as Taste-Masking Excipients for Pharmaceutical Purposes

Adamkiewicz,

Szeleszczuk

2023

Molecules

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It is widely recognized that many active pharmaceutical ingredients (APIs) have a disagreeable taste that affects patient acceptability, particularly in children. Consequently, developing dosage forms with a masked taste has attracted a lot of interest. The application of cyclodextrins as pharmaceutical excipients is highly appreciated and well established, including their roles as drug delivery systems, solubilizers and absorption promoters, agents that improve drug stability, or even APIs. The first work describing the application of the taste-masking properties of CDs as pharmaceutical excipients was published in 2001. Since then, numerous studies have shown that these cyclic oligosaccharides can be effectively used for such purposes. Therefore, the aim of this review is to provide insight into studies in this area. To achieve this aim, a systematic evaluation was conducted, which resulted in the selection of 67 works representing both successful and unsuccessful works describing the application of CDs as taste-masking excipients. Particular attention has been given to the methods of evaluation of the taste-masking properties and the factors affecting the outcomes, such as the choice of the proper cyclodextrin or guest–host molar ratio. The conclusions of this review reveal that the application of CDs is not straightforward; nevertheless, this solution can be an effective, safe, and inexpensive method of taste masking for pharmaceutical purposes.

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A Review of Applications of Solid-State Nuclear Magnetic Resonance (ssNMR) for the Analysis of Cyclodextrin-Including Systems

Cited by 12 publications

References 102 publications

Cyclodextrin Metal–Organic Frameworks as a Drug Delivery System for Selected Active Pharmaceutical Ingredients

Cyclodextrin Metal–Organic Frameworks as a Drug Delivery System for Selected Active Pharmaceutical Ingredients

Application of Cyclodextrin for Cancer Immunotherapy

Review of Applications of Cyclodextrins as Taste-Masking Excipients for Pharmaceutical Purposes

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