A Review of Antidepressant-Associated Hypomania in Those Diagnosed with Unipolar Depression—Risk Factors, Conceptual Models, and Management

Gill, Nav; Bayes, Adam; Parker, Gordon

doi:10.1007/s11920-020-01143-6

Cited by 16 publications

(19 citation statements)

References 68 publications

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“…18 Previous studies supported the notion that female sex might be a risk factor for antidepressant-associated hypomania. 17 However, studies did not indicate a gender difference for the treatment-emergent mania in the child and adolescent population. Sex-specific neuronal circuitry, genetic risk, and endocrine abnormalities might contribute to the biological vulnerability for antidepressant-induced activation in female patients.…”

Section: Discussionmentioning

confidence: 97%

“…13 Some authors have also suggested that women with BD were more likely to receive antidepressants and female sex is a significant risk factor for manic switch. [16][17][18][19] Besides, in the extant literature of PBD, a population-based study by Martin et al (2004) proposed peripubertal children were more susceptible to antidepressantinduced manic conversion, compared to the older age groups. 20 Strawn et al (2014) also investigated adverse reactions causing antidepressant discontinuation (eg, irritability, hyperactivity, aggression, and impulsivity) among younger BD offspring.…”

Section: Introductionmentioning

confidence: 99%

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Index depressive episode and antidepressant exposure were associated with illness characteristics of pediatric bipolar disorder

İnal

Ermiş

Koç

et al. 2021

Acta Psychiatr Scand

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Objective: Pediatric bipolar disorder (PBD) is a serious, recurrent disorder leading to severe functional impairment. As a first mood episode, index episode could affect the long-term course of the illness. This study aimed to investigate the clinical characteristics of youth with PBD from our multicenter, nationwide, naturalistic followup samples and to identify (i) the effects of index mood episode and (ii) the effect of previous antidepressant treatments on the age at mania onset of PBD. Method:The study sample consisted of 271 youth with BD-I followed by the child and adolescent psychiatry clinics of seven different university hospitals and three research state hospitals, representing six geographic regions across Turkey. All diagnoses were made according to structured interviews, and all data were retrospectively obtained from clinical records by the clinicians.

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Section: Discussionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

Index depressive episode and antidepressant exposure were associated with illness characteristics of pediatric bipolar disorder

İnal

Ermiş

Koç

et al. 2021

Acta Psychiatr Scand

View full text Add to dashboard Cite

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“…It is not yet understood whether AIHM occurs due to the psychopharmacological effects of drugs or patients with previously undiagnosed bipolar disorder (BD). Some studies indicate that the potential risk factors for AIHM are female gender, having a younger age onset of depression, BD history in the family, having psychosis, severe depressive symptoms with hospitalization, and psychomotor retardation [ 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

Vortioxetine Induced Hypomania: A Case Presentation and Review of the Literature

Tunc

Tunç

2022

Clin Psychopharmacol Neurosci

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Antidepressant-induced hypomania/mania is a complex issue that can be seen in mood disorders but is not clarified. There are case reports in the literature regarding vortioxetine-induced mania and hypomania; however, there is insufficient data. Here, we aim to present a case of vortioxetine-induced hypomania in a major depressive disorder patient who previously used various antidepressants but did not experience hypomania or mania. Our case is expected to contribute to the literature.

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“…It can be linked to antidepressant treatments, and therefore antidepressants should be associated with mood stabilizers in bipolar patients[ 30 ]. Following the Diagnostic and Statistical Manual of Mental Disorders-5 criteria, hypomanic symptoms subsiding after stopping the antidepressants are called "antidepressant-induced hypomania", otherwise the episode can be defined as a true HMS[ 31 , 32 ].…”

Section: Introductionmentioning

confidence: 99%

Hypomanic/manic switch after transcranial magnetic stimulation in mood disorders: A systematic review and meta-analysis

Miuli¹,

Sepede²,

Stigliano³

et al. 2021

WJP

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BACKGROUND Nowadays there is an increasing use of transcranial magnetic stimulation (TMS) both in neurological and psychiatric fields. After Food and Drug Administration approval of TMS for the therapy of treatment-resistant depression, TMS has been widely used in the context of mood disorders (MD). However, growing reports regarding the possibility of developing hypomanic/manic switch (HMS) have generated concern regarding its use in MDs. AIM To investigate the actual risk of developing HMS due to TMS in the treatment of MD. METHODS We led our research on PubMed, Scopus and Web of Science on March 22, 2020, in accordance to the PRISMA guidelines for systematic review. Only double blind/single blind studies, written in English and focused on the TMS treatment of MD, were included. A meta-analysis of repetitive TMS protocol studies including HMS was conducted using RevMan 5.4 software. The assessment of Risk of Bias was done using Cochrane risk of bias tool. This protocol was registered on PROSPERO with the CRD42020175811 code. RESULTS Twenty-five studies were included in our meta-analysis: Twenty-one double blind randomized controlled trials (RCT) and four single blind-RCT (no. of subjects involved in active stimulation = 576; no. of subjects involved in sham protocol = 487). The most frequently treated pathology was major depressive episode/major depressive disorder, followed by resistant depression, bipolar depression and other MD. The majority of the studies used a repetitive TMS protocol, and the left dorsolateral prefrontal cortex was the main target area. Side effects were reported in eight studies and HMS (described as greater energy, insomnia, irritability, anxiety, suicidal attempt) in four studies. When comparing active TMS vs sham treatment, the risk of developing HMS was not significantly different between conditions. CONCLUSION Applying the most usual protocols and the appropriate precautionary measures, TMS seems not to be related to HMS development.

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A Review of Antidepressant-Associated Hypomania in Those Diagnosed with Unipolar Depression—Risk Factors, Conceptual Models, and Management

Cited by 16 publications

References 68 publications

Index depressive episode and antidepressant exposure were associated with illness characteristics of pediatric bipolar disorder

Index depressive episode and antidepressant exposure were associated with illness characteristics of pediatric bipolar disorder

Vortioxetine Induced Hypomania: A Case Presentation and Review of the Literature

Hypomanic/manic switch after transcranial magnetic stimulation in mood disorders: A systematic review and meta-analysis

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