A Review of American Cancer Society Estimates of Cancer Cases and Deaths

Silverberg, B S Edwin; Lubera, John A.

doi:10.3322/canjclin.33.1.2

Cited by 99 publications

(73 citation statements)

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“…The survival of patients with adenocarcinoma of the pancreas is worse than that with any other gastrointestinal malignancy (1). The principal reasons for the poor prognosis include difficulties diagnosing pancreatic adenocarcinoma at a localized resectable stage and the propensity of the tumor for early metastasis to regional lymph nodes and the liver.…”

Section: Introductionmentioning

confidence: 99%

Impact of Vascular Endothelial Growth Factor-C and -D Expression in Human Pancreatic Cancer

Kurahara

Takao

Maemura

et al. 2004

Clinical Cancer Research

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Purpose: The aim of this study was to evaluate the expression of vascular endothelial growth factor (VEGF)-C and -D in pancreatic cancer and to reveal its relation to lymph node metastasis.Experimental Design: Formalin-fixed, paraffin-embedded blocks were obtained from 58 patients with pancreatic head cancer. All of the patients underwent a curative resection. The total number of resected lymph nodes was 1,058. The expressions of VEGF-C and -D were evaluated by immunohistochemical staining. To evaluate the relation to lymph node metastasis, the expressions of VEGF-C and -D between the marginal and central portions in the tumor were compared. When >25% of the tumor cells showed distinct staining, the portion was judged as high expression.Results: The two groups with high expression of VEGF-C (P ‫؍‬ 0.015) and VEGF-D (P ‫؍‬ 0.020) in the marginal portion had a significantly higher incidence of lymph node metastasis compared with the groups with low expression, respectively. Furthermore, the group with high expression of both VEGF-C and -D in the marginal portion had a higher incidence of lymph node metastasis compared with the group with low expression (P ‫؍‬ 0.007). The 5-year survival rate of patients with high expression of both VEGF-C and -D in the marginal portion was significantly lower than that of patients with low expression of both VEGF-C and -D (P ‫؍‬ 0.017).Conclusions: VEGF-C and -D expression in tumor cells in the marginal portion of the tumor significantly associated with lymphatic metastasis and prognosis in patients with pancreatic head cancer.

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Section: Introductionmentioning

confidence: 99%

Impact of Vascular Endothelial Growth Factor-C and -D Expression in Human Pancreatic Cancer

Kurahara

Takao

Maemura

et al. 2004

Clinical Cancer Research

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“…The incidence increases with age and approximately 30% of all new breast tumours occur in women over 70 years of age (Silverberg et al, 1988;Decarli et al, 1989).…”

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confidence: 99%

Long-term follow-up of elderly patients with operable breast cancer treated with surgery without axillary dissection plus adjuvant tamoxifen

Martelli

DePalo²,

Rossi³

et al. 1995

Br J Cancer

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al., 1988) comparing surgery with tamoxifen did not find a difference in survival between the two groups but locoregional control led to a better result in the surgically treated patients. This led to the conclusion that optimum treatment for elderly patients could include both surgery and tamoxifen. A randomised study (Bates et al., 1991) compared tamoxifen only with optimal surgery followed by adjuvant tamoxifen. The overall survival after 3 years was similar between the two groups but a statistically significant higher locoregional relapse rate was reported in the group treated by tamoxifen only.The rationale of the present study was that non-randomised clinical studies (Helleberg et al., 1982;Preece et al., 1982;Allan et al., 1985) showed that tamoxifen as first-line treatment was of value in a selected group of elderly breast cancer patients. The question was whether surgery without axillary dissection combined with tamoxifen in patients with breast cancer and without clinical nodal involvement could give the same results in terms of overall survival, disease-free survival and quality of life compared with more radical treatments.In a previous paper (Martelli et al., 1993) (Hermanek et al., 1987), 77 (24%) a T2, 1 (0.3%) a T3 and 24 patients (7.5%) presented with a tumour infiltrating the skin but not the underlying muscle (T4b). All patients had surgery performed under local anaesthesia without axillary dissection; 298 underwent wide lumpectomy or quadrantectomy and 23 total mastectomy. The conservative surgical techniques have been previously described (Veronesi et al., 1990;Galante et al., 1992).All patients underwent resection of the tumour with removal of at least 2 cm of normal tissue to ensure a specimen with tumour-free margins. Patients with the margins of resection in tumour tissue were excluded from the analysis, since they were candidates for a re-excision or radiotherapy.Independent of hormone receptor status, all patients received indefinitely 20 mg tamoxifen daily from the time of surgery. Tumour specimens were assayed for both oestrogen receptor (ER) and progesterone receptor (PgR) levels by using the dextran-coated charcoal Scatchard analysis. RecepCorrespondence: G Martelli

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“…Gliomas are the most common primary tumors of the human central nervous system (1). The majority of brain tumors are astrocytomas (1), which are most commonly divided into three histopathological malignancy groups (2)(3)(4).…”

mentioning

confidence: 99%

Loss of distinct regions on the short arm of chromosome 17 associated with tumorigenesis of human astrocytomas.

El-Azouzi

Chung

Farmer

et al. 1989

Proc. Natl. Acad. Sci. U.S.A.

123

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Astrocytomas, including glioblastoma multiforme, represent the most frequent and deadly primary neoplasms of the human nervous system. Despite a number of previous cytogenetic and oncogene studies primarily focusing on malignant astrocytomas, the primary mechanism of tumor initiation has remained obscure. The loss or inactivation of "tumor suppressor" genes are thought to play a fundamental role in the development of many human cancers. Thus, we have analyzed astrocytomas of various histological malignancy grades with polymorphic DNA markers to search for specific chromosomal deletions potentially pointing to loci containing tumor suppressor genes. Loss of constitutional heterozygosity indicating chromosomal loss or deletions was most frequently seen for markers on the short arm of chromosome 17 in 50% of the informative tumors (5 of 10 informative cases) and, to a lesser extent, for markers on chromosomes 1 and 10. Deletions on chromosome 17p were seen in both low-grade and high-

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A Review of American Cancer Society Estimates of Cancer Cases and Deaths

Cited by 99 publications

References 0 publications

Impact of Vascular Endothelial Growth Factor-C and -D Expression in Human Pancreatic Cancer

Impact of Vascular Endothelial Growth Factor-C and -D Expression in Human Pancreatic Cancer

Long-term follow-up of elderly patients with operable breast cancer treated with surgery without axillary dissection plus adjuvant tamoxifen

Loss of distinct regions on the short arm of chromosome 17 associated with tumorigenesis of human astrocytomas.

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