A review of adverse events related to synthetic cartilage implant for the first metatarsophalangeal joint: An analysis of Manufacturer and User Facility Device Experience database from 2016 to 2023

Radcliffe, Michael J.; Roukis, Thomas S.

doi:10.1016/j.fastrc.2023.100356

Foot & Ankle Surgery: Techniques, Reports & Cases

2024

DOI: 10.1016/j.fastrc.2023.100356

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A review of adverse events related to synthetic cartilage implant for the first metatarsophalangeal joint: An analysis of Manufacturer and User Facility Device Experience database from 2016 to 2023

Michael J. Radcliffe,

Thomas S. Roukis

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2024

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Tribomechanical Properties of PVA/Nomex® Composite Hydrogels for Articular Cartilage Repair

Santos,

Marto-Costa,

Branco

et al. 2024

Gels

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Due to the increasing prevalence of articular cartilage diseases and limitations faced by current therapeutic methodologies, there is an unmet need for new materials to replace damaged cartilage. In this work, poly(vinyl alcohol) (PVA) hydrogels were reinforced with different amounts of Nomex® (known for its high mechanical toughness, flexibility, and resilience) and sterilized by gamma irradiation. Samples were studied concerning morphology, chemical structure, thermal behavior, water content, wettability, mechanical properties, and rheological and tribological behavior. Overall, it was found that the incorporation of aramid nanostructures improved the hydrogel’s mechanical performance, likely due to the reinforcement’s intrinsic strength and hydrogen bonding to PVA chains. Additionally, the sterilization of the materials also led to superior mechanical properties, possibly related to the increased crosslinking density through the hydrogen bonding caused by the irradiation. The water content, wettability, and tribological performance of PVA hydrogels were not compromised by either the reinforcement or the sterilization process. The best-performing composite, containing 1.5% wt. of Nomex®, did not induce cytotoxicity in human chondrocytes. Plugs of this hydrogel were inserted in porcine femoral heads and tested in an anatomical hip simulator. No significant changes were observed in the hydrogel or cartilage, demonstrating the material’s potential to be used in cartilage replacement.

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Tribomechanical Properties of PVA/Nomex® Composite Hydrogels for Articular Cartilage Repair

Santos,

Marto-Costa,

Branco

et al. 2024

Gels

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show abstract

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A review of adverse events related to synthetic cartilage implant for the first metatarsophalangeal joint: An analysis of Manufacturer and User Facility Device Experience database from 2016 to 2023

Cited by 1 publication

References 17 publications

Tribomechanical Properties of PVA/Nomex® Composite Hydrogels for Articular Cartilage Repair

Tribomechanical Properties of PVA/Nomex® Composite Hydrogels for Articular Cartilage Repair

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