A REVIEW OF ADRENAL CORTICAL HYPERTROPHY<sup>1</sup>

Tepperman, L.; Engel, Frank L.; Long, C. N. H.

doi:10.1210/endo-32-5-373

Cited by 169 publications

(37 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The phenomenon of compensatory adrenal growth (Tepperman et al 1943) has been used extensively to investigate the mechanisms underlying adrenal growth. The procedure in which one adrenal is surgically removed results in a rapid increase (within 24 h) in the size of the contralateral gland as measured by an increase in wet weight, and DNA and RNA synthesis.…”

Section: Compensatory Adrenal Growthmentioning

confidence: 99%

60 YEARS OF POMC: N-terminal POMC peptides and adrenal growth

Bicknell

2016

Journal of Molecular Endocrinology

View full text Add to dashboard Cite

The peptide hormones contained within the sequence of proopiomelanocortin (POMC) have diverse roles ranging from pigmentation to regulation of adrenal function to control of our appetite. It is generally acknowledged to be the archetypal hormone precursor, and as its biology has been unravelled, so too have many of the basic principles of hormone biosynthesis and processing. This short review focuses on one group of its peptide products, namely, those derived from the N-terminal of POMC and their role in the regulation of adrenal growth. From a historical and a personal perspective, it describes how their role in regulating proliferation of the adrenal cortex was identified and also highlights the key questions that remain to be answered.

show abstract

Section: Compensatory Adrenal Growthmentioning

confidence: 99%

60 YEARS OF POMC: N-terminal POMC peptides and adrenal growth

Bicknell

2016

Journal of Molecular Endocrinology

View full text Add to dashboard Cite

show abstract

“…Five of the patients showed increases in excretion during the febrile, or early post-febrile stages, which were higher than levels encountered in normal subjects. The 2 patients which showed no augmentation in output were ill for only 1 (Table III). Assays were done on patient C. D. for a 48-hour period at home before admission to the hospital, and for another 48 hours pre-operatively while he was confined to bed.…”

Section: Resultsmentioning

confidence: 99%

“…

…”

mentioning

confidence: 99%

The Effect of Infection and Trauma on the Excretion of Urinary Cortin 1

Shipley¹,

Dorfman²,

Buchwald³

et al. 1946

J. Clin. Invest.

View full text Add to dashboard Cite

Adrenal cortical hyperplasia which is known to occur during infection and after trauma (1,2) suggests the occurrence of a corresponding increase in the physiological activity of the gland. Scant information is available, however, bearing directly on the functional status of the adrenal cortex during conditions of stress. It would be important to know not only whether periods of stress are accompanied by increased cortical function, but also whether recovery might be influenced by the functional state of the adrenal cortex, and whether such conditions as post-infectious asthenia might be attributable to adrenal exhaustion resulting from extreme stimulation during the active phase of the-disease.Although the excretion of neutral 17-ketosteroids is influenced by adrenal cortical function, the chemical determination of these steroids affords a poor measure of the activity of the gland, inasmuch as the adrenal is not the sole source of the compounds in this fraction. Moreover, information as to the precursors of urinary 17-ketosteroids is far from complete. The one classical precursor, testosterone, has insignificant cortinlike activity.Browne and coworkers demonstrated the presence of cortin-like activity in the urine of postoperative patients and patients suffering infection or other types of stress, but were not able to detect the material in normal urine (3a and b). Evidence has recently been adduced that the substance is present in the urine of normal men and women who have not been subjected to stress, and that it possesses the physiological properties of cortical hormone when tested by a great variety of methods (4 to 9). Furthermore, the material has been ob- served to disappear from the urine of monkeys after adrenalectomy, but not after gonadectomy (10), and activity has not been detectable in the urine of patients with Addison's disease (11). It may therefore be assumed with justification that the urinary substance has its origin in the adrenal cortex, and that its rate of excretion should be influenced by variations in cortical function.The intent of the work herein reported was to determine the urinary cortin output of human subjects in the normal state, during stress, and during recovery from stress. It was considered desirable to employ methods which would allow expression of cortin values in terms of a pure cortical hormone, rather than as arbitrary biological units. These studies are a part of a broader investigation of the physiology and chemistry of active urinary cortical hormones. METHODSPreparation of extracts. Urine samples were collected in 48-hour lots, and were preserved with toluene. The pH varied from approximately 5.5 to 6.5. One-fourth volume of ethylene dichloride was added, and after being shaken for 2 minutes in a mechanical shaker, the ethylene dichloride was separated from the urine with a Sharples centrifuge. The urine was extracted twice more with the same volume of ethylene dichloride and the 3 extracts pooled and evaporated in vacuo at an internal temperature below 400 C. After ...

show abstract

“…The differences in adrenal gland size may reflect differences in reaction to the environment. Rats bred for several generations in conditions of high temperature and humidity have been reported to show a relative increase in adrenal gland size and continuous hyperactivity of the adrenal gland also results in its enlargement (Tepperman et al 1943). The adrenal glands of animals exposed to tropical conditions show morphological as well as histological and histochemical changes (Schmidt and Schmidt 1938;Flexner and GroHman 1939;Bernstein 1941).…”

Section: Discussionmentioning

confidence: 99%

The Concentrations of Lipids in the Adrenal Cortical Tissue of Genetically Different Types of Cattle

Jc¹

1974

Aust. Jnl. Of Bio. Sci.

View full text Add to dashboard Cite

The concentrations of lipids in the plasma and adrenal cortical tissue were compared in British (Bos taurus) and Zebu (Brahman cross and Africander cross) cattle. Plasma cholesterol and phospholipid concentrations were higher (P < 0'001) in Zebu than in British animals. In grazing steers the adrenal cholesterol concentrations were higher (P < 0'01) in Zebu than in British steers but phospholipid concentrations were lower (P < 0'01) in Brahman cross than in Africander cross and British animals. The correlations between the concentrations of cholesterol in plasma and adrenal glands were significant. In Zebu steers on different dietary treatments the concentrations of cholesterol and phospholipid were higher (P < 0'01) and triglyceride lower (P < 0·01) in the adrenal tissue of steers growing normally than of steers losing weight. The adrenal to body weight ratios were lower (P < 0'01) in Brahman cross than in Africander cross and British grazing animals.

show abstract

A REVIEW OF ADRENAL CORTICAL HYPERTROPHY¹

Cited by 169 publications

References 0 publications

60 YEARS OF POMC: N-terminal POMC peptides and adrenal growth

60 YEARS OF POMC: N-terminal POMC peptides and adrenal growth

The Effect of Infection and Trauma on the Excretion of Urinary Cortin 1

The Concentrations of Lipids in the Adrenal Cortical Tissue of Genetically Different Types of Cattle

Contact Info

Product

Resources

About

A REVIEW OF ADRENAL CORTICAL HYPERTROPHY1

Cited by 169 publications

References 0 publications

60 YEARS OF POMC: N-terminal POMC peptides and adrenal growth

60 YEARS OF POMC: N-terminal POMC peptides and adrenal growth

The Effect of Infection and Trauma on the Excretion of Urinary Cortin 1

The Concentrations of Lipids in the Adrenal Cortical Tissue of Genetically Different Types of Cattle

Contact Info

Product

Resources

About

A REVIEW OF ADRENAL CORTICAL HYPERTROPHY¹