A Review of Abdominal Meshes for Hernia Repair—Current Status and Emerging Solutions

Najm, Alfred; Niculescu, Adelina-Gabriela; Gaspar, Bogdan Severus; Grumezescu, Alexandru Mihai; Beuran, Mircea

doi:10.3390/ma16227124

Cited by 4 publications

(1 citation statement)

References 105 publications

(176 reference statements)

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“…These meshes can be constructed from a single material or as composite structures. In addition, ongoing research addresses the development of new engineered materials, such as hydrogels or electrospun fiber meshes, with the goal of improving the safety and efficacy of these repair procedures, as highlighted in recent reviews [ 33 , 34 , 35 ]. The superiority of PP mesh in IH and POP repair is due to its combination of properties, including biocompatibility, strength, durability, minimal tissue reaction, ease of handling, cost effectiveness, proven efficacy, wide availability and versatility.…”

Section: Introductionmentioning

confidence: 99%

Effect of Functionalization of Texturized Polypropylene Surface by Silanization and HBII-RGD Attachment on Response of Primary Abdominal and Vaginal Fibroblasts

Quiles,

Rodríguez-Contreras,

Guillem-Marti

et al. 2024

Polymers

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Soft tissue defects, such as incisional hernia or pelvic organ prolapse, are prevalent pathologies characterized by a tissue microenvironment rich in fragile and dysfunctional fibroblasts. Precision medicine could improve their surgical repair, currently based on polymeric materials. Nonetheless, biomaterial-triggered interventions need first a better understanding of the cell-material interfaces that truly consider the patients’ biology. Few tools are available to study the interactions between polymers and dysfunctional soft tissue cells in vitro. Here, we propose polypropylene (PP) as a matrix to create microscale surfaces w/wo functionalization with an HBII-RGD molecule, a fibronectin fragment modified to include an RGD sequence for promoting cell attachment and differentiation. Metal mold surfaces were roughened by shot blasting with aluminum oxide, and polypropylene plates were obtained by injection molding. HBII-RGD was covalently attached by silanization. As a proof of concept, primary abdominal and vaginal wall fasciae fibroblasts from control patients were grown on the new surfaces. Tissue-specific significant differences in cell morphology, early adhesion and cytoskeletal structure were observed. Roughness and biofunctionalization parameters exerted unique and combinatorial effects that need further investigation. We conclude that the proposed model is effective and provides a new framework to inform the design of smart materials for the treatment of clinically compromised tissues.

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Section: Introductionmentioning

confidence: 99%

Effect of Functionalization of Texturized Polypropylene Surface by Silanization and HBII-RGD Attachment on Response of Primary Abdominal and Vaginal Fibroblasts

Quiles,

Rodríguez-Contreras,

Guillem-Marti

et al. 2024

Polymers

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Self-organising maps in the analysis of strains of human abdominal wall to identify areas of similar mechanical behaviour

Troka,

Szepietowska,

Lubowiecka

2024

Journal of the Mechanical Behavior of Biomedical Materials

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Commercial classification of conventional polypropylene and polyester meshes for groin hernia repair: A descriptive study

Deveci,

Öberg,

Rosenberg

2024

IJAWHS

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OBJECTIVE: Despite established definitions of weight classification available from the European Hernia Society and others, a discrepancy exists in the classification used by mesh companies. This descriptive study aimed to summarize available data from mesh companies regarding how meshes are classified according to weight. MATERIALS AND METHODS: We included Food and Drug Administration (FDA)-approved conventional non-coated flat meshes made of polypropylene or polyester. To access all medical companies that produce hernia repair meshes, we conducted a broad search on Access Global Unique Device Identification Database, which is a database created in collaboration between the National Library of Medicine and the FDA. RESULTS: Five companies with 14 meshes met the inclusion criteria. Meshes were classified by the companies as lightweight (seven meshes), heavyweight (one mesh), or lacking specific weight terms (six meshes). Lightweight meshes had a median density of 48 g/m2 (range 36–114 g/m2), while the heavyweight mesh had a density of 125 g/m2. Six meshes were neither defined as lightweight nor heavyweight, and they had a median density of 62 g/m2 (44–76 g/m2). Seven meshes were defined as macroporous, with a median pore size of 2.8 mm (range 1.5–3.5 mm). Six meshes had data on the pore size but did not specify microporous or macroporous characteristics. CONCLUSIONS: A discrepancy exists between companies’ and researchers’ definition of lightweight and heavyweight meshes. Further investigation into mesh classification is warranted to establish clear guidelines for companies, researchers, and clinicians.

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A Review of Abdominal Meshes for Hernia Repair—Current Status and Emerging Solutions

Cited by 4 publications

References 105 publications

Effect of Functionalization of Texturized Polypropylene Surface by Silanization and HBII-RGD Attachment on Response of Primary Abdominal and Vaginal Fibroblasts

Effect of Functionalization of Texturized Polypropylene Surface by Silanization and HBII-RGD Attachment on Response of Primary Abdominal and Vaginal Fibroblasts

Self-organising maps in the analysis of strains of human abdominal wall to identify areas of similar mechanical behaviour

Commercial classification of conventional polypropylene and polyester meshes for groin hernia repair: A descriptive study

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