A Review: Meridianins and Meridianins Derivatives

Abstract

Meridianins are a family of indole alkaloids derived from Antarctic tunicates with extensive pharmacological activities. A series of meridianin derivatives had been synthesized by drug researchers. This article reviews the extraction and purification methods, biological activities and pharmacological applications, pharmacokinetic characters and chemical synthesis of meridianins and their derivatives. And prospects on discovering new bioactivities of meridianins and optimizing their structure for the improvement of the ADMET properties are provided.

Current Status of Indole-Derived Marine Natural Products: Synthetic Approaches and Therapeutic Applications

“…Moreover, 44 exhibited antibiofilm potential against methicillin-resistant Staphylococcus aureus (MRSA) [ 36 ]. In general, the Meridianin family demonstrated wide biological activities which are summarized in Table 1 [ 56 , 57 ].…”

“…Thus, the first was Aplidium meridianum, from which Meridianins A-E were isolated, [55] but other examples include Aplidium falklandicum and Synoicum sp. [56]. tunicates.…”

“…Thus, the first was Aplidium meridianum, from which Meridianins A-E were isolated, [55] but other examples include Aplidium falklandicum and Synoicum sp. [56]. Meridianins B-E (42)(43)(44)(45) are notable for their demonstrated cytotoxic effects against adenocarcinoma and murine mammary tumor cell lines (IC50 = 11.4, 9.3, 33.9, and 11.1 µM, respectively) [55].…”

“…Moreover, 44 exhibited antibiofilm potential against methicillin-resistant Staphylococcus aureus (MRSA) [36]. In general, the Meridianin family demonstrated wide biological activities which are summarized in Table 1 [56,57]. Meridianins B-E (42)(43)(44)(45) are notable for their demonstrated cytotoxic effects against adenocarcinoma and murine mammary tumor cell lines (IC 50 = 11.4, 9.3, 33.9, and 11.1 µM, respectively) [55].…”

A Survey on the Synthesis of Variolins, Meridianins, and Meriolins—Naturally Occurring Marine (aza)Indole Alkaloids and Their Semisynthetic Derivatives

“…There are overviews of some syntheses of meridianins and analogs [ 29 , 30 , 31 ] or variolins [ 32 ]. Just recently, Xiao published a brief survey on meridianin syntheses and their biological properties [ 33 ]. In 2009, Morris and coworkers summarized syntheses of variolins, meridianins, and meriolins and their biological properties in a review article [ 34 ].…”