A review for the pharmacological effect of lycopene in central nervous system disorders

Chen, Dongjian; Huang, Chao; Chen, Zhuo

doi:10.1016/j.biopha.2018.12.151

Cited by 143 publications

(70 citation statements)

References 133 publications

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“…In addition, lycopene is a natural neuroprotective agent. It seems that this carotenoid contributes to cognitive longevity [18] and the treatment of several neuronal diseases, including cerebral ischemia, Parkinson's disease (PD), Alzheimer's disease (AD), subarachnoid haemorrhage, epilepsy, Huntington's disease, and depression [19]. There are several other clinical applications for this available phytochemical.…”

Section: Introductionmentioning

confidence: 99%

Lycopene as a Natural Antioxidant Used to Prevent Human Health Disorders

et al. 2020

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Lycopene, belonging to the carotenoids, is a tetraterpene compound abundantly found in tomato and tomato-based products. It is fundamentally recognized as a potent antioxidant and a non-pro-vitamin A carotenoid. Lycopene has been found to be efficient in ameliorating cancer insurgences, diabetes mellitus, cardiac complications, oxidative stress-mediated malfunctions, inflammatory events, skin and bone diseases, hepatic, neural and reproductive disorders. This review summarizes information regarding its sources and uses amongst different societies, its biochemistry aspects, and the potential utilization of lycopene and possible mechanisms involved in alleviating the abovementioned disorders. Furthermore, future directions with the possible use of this nutraceutical against lifestyle-related disorders are emphasized. Its protective effects against recommended doses of toxic agents and toxicity and safety are also discussed.

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Section: Introductionmentioning

confidence: 99%

Lycopene as a Natural Antioxidant Used to Prevent Human Health Disorders

et al. 2020

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“…This hypothesis has been supported by previous studies investigating the role of LYC in neurodegenerative disorders [181]. LYC supplementation improves cognitive performance in Tau transgenic mice expressing P301L mutation, attenuate Aβ-induced cellular toxicity in cultured neurons [179,181], and reduces the activation of caspase-3 induced by intracerebroventricular Aβ1-42 injection in rat hippocampus [181].…”

Section: Lycopenementioning

confidence: 56%

“…Many studies show that free radical level and amyloid-induced mitochondrial dysfunction lowered [178] after LYC treatment. Recently, a study demonstrated that 8 weeks of LYC treatment reversed MDA increase and glutathione peroxidase decrease in serum of tau transgenic mice expressing P301L mutation [179][180][181].…”

Section: Lycopenementioning

confidence: 99%

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Functional Foods: An Approach to Modulate Molecular Mechanisms of Alzheimer’s Disease

Atlante

Amadoro

Bobba

et al. 2020

Cells

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A new epoch is emerging with intense research on nutraceuticals, i.e., “food or food product that provides medical or health benefits including the prevention and treatment of diseases”, such as Alzheimer’s disease. Nutraceuticals act at different biochemical and metabolic levels and much evidence shows their neuroprotective effects; in particular, they are able to provide protection against mitochondrial damage, oxidative stress, toxicity of β-amyloid and Tau and cell death. They have been shown to influence the composition of the intestinal microbiota significantly contributing to the discovery that differential microorganisms composition is associated with the formation and aggregation of cerebral toxic proteins. Further, the routes of interaction between epigenetic mechanisms and the microbiota–gut–brain axis have been elucidated, thus establishing a modulatory role of diet-induced epigenetic changes of gut microbiota in shaping the brain. This review examines recent scientific literature addressing the beneficial effects of some natural products for which mechanistic evidence to prevent or slowdown AD are available. Even if the road is still long, the results are already exceptional.

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“…Lycopene, one of the most common carotenoids found in carrots, tomatoes, and papayas, exhibits various beneficial activities including antiproliferative, antitumor, antioxidant, anti-inflammatory, antidiabetes, cardiovascular-protective, and neuroprotective effects [ 94 ]. Lycopene inhibited pro-inflammatory mediator production and elevated antioxidant enzyme levels by upregulating the HO-1 activity and AMPK pathway and inhibited the apoptosis of neuronal cell by suppressing caspase-3 activity [ 95 , 96 ].…”

Section: Neuroprotective Effects Of Potential Natural Compounds Anmentioning

confidence: 99%

The Role of Natural Compounds and their Nanocarriers in the Treatment of CNS Inflammation

et al. 2020

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Neuroinflammation, which is involved in various inflammatory cascades in nervous tissues, can result in persistent and chronic apoptotic neuronal cell death and programmed cell death, triggering various degenerative disorders of the central nervous system (CNS). The neuroprotective effects of natural compounds against neuroinflammation are mainly mediated by their antioxidant, anti-inflammatory, and antiapoptotic properties that specifically promote or inhibit various molecular signal transduction pathways. However, natural compounds have several limitations, such as their pharmacokinetic properties and stability, which hinder their clinical development and use as medicines. This review discusses the molecular mechanisms of neuroinflammation and degenerative diseases of CNS. In addition, it emphasizes potential natural compounds and their promising nanocarriers for overcoming their limitations in the treatment of neuroinflammation. Moreover, recent promising CNS inflammation-targeted nanocarrier systems implementing lesion site-specific active targeting strategies for CNS inflammation are also discussed.

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A review for the pharmacological effect of lycopene in central nervous system disorders

Cited by 143 publications

References 133 publications

Lycopene as a Natural Antioxidant Used to Prevent Human Health Disorders

Lycopene as a Natural Antioxidant Used to Prevent Human Health Disorders

Functional Foods: An Approach to Modulate Molecular Mechanisms of Alzheimer’s Disease

The Role of Natural Compounds and their Nanocarriers in the Treatment of CNS Inflammation

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