A Review: Floating Drug Delivery System as a Tool to Improve Dissolution Rate in Gastric

Sopyan, Iyan; Sriwidodo, Sriwidodo; Wahyuningrum, Retno; Aliza, P Norisca

doi:10.22159/ijap.2020v12i4.38415

Cited by 9 publications

(10 citation statements)

References 9 publications

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“…It aids in the location of dosage forms in the GIT, as well as the prediction and correlation of gastric emptying time and dosage form passage in the GIT. The incorporation of a radio-opaque substance into a solid dosage shape allows for X-ray visualisation 31 .…”

Section: X-ray Methodsmentioning

confidence: 99%

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Floating Drug Delivery System

Thakur¹,

Ramya²,

Shah³

et al. 2021

J. Drug Delivery Ther.

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Floating drug delivery system (FDDS) helps to improve the buoyancy property of the drug over the gastric fluids and hence maintain the longer duration of action. It is helpful in minimizing the dosing frequency. The density of dosage form must be less than the density of gastric contents (1.004 gm/ml) in FDDS. It may effervescent or non-effervescent system. The drugs having narrow absorption window in GIT is good candidate for the floating drug delivery system. The main objective of writing this review article is to compile the recent literature with special focus on classification, method of preparation, mechanism of action advantages and disadvantages. Keywords: Floating drug delivery system, Sustained release, controlled release, Floating tablet, Evaluation, Application, Gastro-retentive drug delivery system.

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Section: X-ray Methodsmentioning

confidence: 99%

“…When using a pH 6.8 buffer dissolution medium at 370.5 °C, the tablet swelling index correlates to the tablet site in the dissolution tool basket (type 1). At each time point, the trials were repeated three times 31 .…”

Section: Swelling Indexmentioning

confidence: 99%

Floating Drug Delivery System

Thakur¹,

Ramya²,

Shah³

et al. 2021

J. Drug Delivery Ther.

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“…There are several types of gastroretentive excipients: excipients that float in gastric fluid with low foaming or density mechanism, bioadhesive excipients, excipients that expand in gastric fluidal, and excipients that sink in gastric fluidal with a high-density mechanism. Several preparations with excipient combinations have also been developed [16,27,[39][40][41][42][43][44].…”

Section: Gastroretentive Tabletmentioning

confidence: 99%

An Experimental Design in the Optimization of Various Tablet Excipient Formulations = a Concise Review

Sopyan

2022

Int J App Pharm

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The use of an experimental design technique in the development of various pharmaceutical preparations, including tablet preparations, has become the latest trend. Because of their ease of use, tablet formulations are popular among both producers and patients. To increase the usage of tablets in diverse circles and settings, researchers are working to develop a variety of tablet excipients for various functions. Fast dissolving tablets (FDT), effervescent tablets, modified-release tablets, oral mucoadhesive tablets, gastroretentive tablets, and colon targeted tablets are some of the tablet formats that have been developed in addition to traditional tablets. This review will look at how formulation optimization in tablet preparations has been done during the previous ten years using specific literacies. The articles for this review were found using the keywords tablet, excipient, matrices, formulation, and QBD in specialized databases such as Elsevier, Pubmed, and Cambridge. Other options include Springer publications, material from the Internet, and articles published online by The Lancet Respiratory Medicine, Medscape, and Statpearls. The formulation design strategy is based on the experimental design approach carried out on the kind of tablet preparation, which has distinct important quality parameters.

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“…Part of the proximal developed by fundus in the stomach. The body is the reservoir for ungroomed materials, and the antrum is the primary location for the mixing of gestures and serves as a stomach emptying pump by action pushing 5,6 . In both the fasting and fed phases, gastric emptying takes place.…”

Section: Introductionmentioning

confidence: 99%

“…The FDDS is beneficial for medications with stomach absorption such as antacids and ferrous salts 18 .…”

mentioning

confidence: 99%

Floating Drug Delivery System an Aid to Enhance Dissolution Profile of Gastric

Yadav¹,

Yadav²,

Kumar³

et al. 2021

J. Drug Delivery Ther.

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With the GRDDS, the dose shape remains controllably in the stomach after oral administration, so that the medication may be continually delivered to its absorption receptors in the intestinal tract. The medicine is delivering in a controlled and extended way. Gastro-retentive dose in the stomach area may last for another few hours and substantially lengthen the gastric residence period of the medicines. While the bulk density in the system for the supply of floating medicines (FDDS) exceeds the gastric fluids, it remains for an extended duration in the stomach without altering the rate of decomposition. The medication distributes gradually as the system floats on the stomach juice. As a consequence, stomach residency takes longer and plasma concentrations are well monitored. The therapy of peptic ulcer illness might be beneficial for local activity in the upper portion of the intestine, i.e., a longer stomach residency. In addition, medicines rapidly absorbed in the GI tract will increase bioavailability through delayed stomach release. The regulated gastric retention of solid dose forms can also be accomplished by the simultaneous administration of pharmacological agents, or by sedimentation, flotation processes, muco-adhesion, expansion, changed shape systems, by delaying the stomach emptying. Keywords: Gastro-retentive drug delivery system, Floating drug delivery system, Muco-adhesion, Bioavailability.

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A Review: Floating Drug Delivery System as a Tool to Improve Dissolution Rate in Gastric

Cited by 9 publications

References 9 publications

Floating Drug Delivery System

Floating Drug Delivery System

An Experimental Design in the Optimization of Various Tablet Excipient Formulations = a Concise Review

Floating Drug Delivery System an Aid to Enhance Dissolution Profile of Gastric

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