A Review: Film Forming Gel Novel Drug Delivery System

Abstract

Film forming gels are a novel approach in this area that might present an alternative to the conventional dosage forms used on the skin, such as ointments, creams, gels or patches. The polymeric solution is applied to the skin as a liquid and forms an almost invisible film in situ by solvent evaporation. Transdermal drug delivery system (TDDS) and dermal drug delivery system can provide some desirable performances over conventional pharmaceutical dosage formulations, such as avoiding gut and hepatic first-pass metabolism, improving drug bioavailability, reducing dose frequency and stabilizing drug delivery profiles. The aim of this review was to search for alternatives to the conventional forms in order to reduce skin irritation, improve skin adhesion properties, enhance the drug release and increase the patient acceptability from an aesthetic perspective. Because of their peculiar rheological behaviour, polymeric gels are beneficial in terms of ease of preparation, ease of application, adhesion to the application surface and ability to deliver a wide variety of drugs.

Newfangled Topical Film-Forming Solution for Facilitated Antifungal Therapy: Design, Development, Characterization, and In Vitro Evaluation

“…Film samples were packed in an airtight desiccator containing silica gel for two weeks. The cross-section of the sample was then evaluated by using films that had been randomly and gently immersed in liquid nitrogen [ 31 , 32 ]. On copper stubs, gold-coated sample films and solutions were mounted and then observed by using a 10-kV step-up voltage.…”

Film-Forming Systems for Dermal Drug Delivery

“…Ethanol and isopropanol are particularly suitable solvents for film-forming formulations. Propylene glycol and isopropyl myristate offer the advantage of additional penetration enhancing properties but do not evaporate [ 21 , 33 , 34 , 35 ]. In Table 2 , a selection of solvents and dispersion agents used for film-forming systems are summarised.…”

“…The developed formulations should be free of toxic or allergenic ingredients [ 56 ]. In case of dermal and transdermal systems, the penetration and permeation of the systems must be investigated [ 35 ]. Today, only a few film-forming formulations are on the market.…”

Compatibility Study of Four Binary Combinations of Active Ingredients for Dermal Film Forming Systems

“…Thus, the production of TTSs is based on a number of physicochemical techniques such as lasers, microjets, electroporation, sonophoresis and iontophoresis, microneedles and use of chemical penetration enhancers [35,57,74]. Recently, in situ film-forming systems (on the skin, after spreading in a thin layer) -FFSs which form a film on the skin after spreading in a thin layer, have been developed as a new approach to be used as an alternative to both conventional and transdermal topical formulations [12]. In this paper, four pharmaceutical substances were selected as potential active ingredients ( Figure 1) that could be useful in the form of film-forming systems with dermal and/or transdermal delivery: adapalene (ADA) [23,84], levofloxacin (LEV) [36,69], meloxicam (MEL) [16], and miconazole nitrate (MIC) [10].…”