A review: Fabrication of porous polyurethane scaffolds

Janik, Helena; Marzec, Mateusz

doi:10.1016/j.msec.2014.12.037

Cited by 318 publications

(215 citation statements)

References 73 publications

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“…Scaffolds play a crucial role in tissue engineering, which represents the fabrication of functional replacements for damaged tissues or organs [131]. The function of tissue scaffolds is to provide an appropriate base for tissue growth and cell proliferation, while simultaneously undergoing controlled degradation to non-cytotoxic decomposition products in vivo and supporting the growth and proliferation of the required cell types [132].…”

Section: Porous Biopus-tissue Scaffoldsmentioning

confidence: 99%

“…Techniques for the fabrication of threedimensional porous structures are based on transforming polymers from the solid to liquid state, mostly by melting or dissolving [131].…”

Section: Fabrication Of Porous Biopusmentioning

confidence: 99%

“…In this technique, particles with a specified diameter are added to the polymer solution, with a concentration in the range from 5 % to 2 0% [131]. After solvent evaporation by air-drying, vacuumdrying or freeze-drying, salt particles remain embedded throughout the polymer matrix.…”

Section: Fabrication Of Porous Biopusmentioning

confidence: 99%

See 2 more Smart Citations

Synthesis and structure-property relationships of biodegradable polyurethanes

Pergal¹,

Blaban²

2017

Biodegradable Polymers: Recent Developments and New Perspectives

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Section: Porous Biopus-tissue Scaffoldsmentioning

confidence: 99%

“…Techniques for the fabrication of threedimensional porous structures are based on transforming polymers from the solid to liquid state, mostly by melting or dissolving [131].…”

Section: Fabrication Of Porous Biopusmentioning

confidence: 99%

See 1 more Smart Citation

Synthesis and structure-property relationships of biodegradable polyurethanes

Pergal¹,

Blaban²

2017

Biodegradable Polymers: Recent Developments and New Perspectives

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“…However, conventional fabrication methods create relatively homogeneous scaffolds that cannot present the micro-and nanoscale instructive cues to maintain cell phenotype and behavior. To synergistically incorporate the scaffold architecture within the biological materials, several methods, such as nanoimprinting, 5 electron beam lithography, 6 electrospinning, [7][8][9][10][11] solvent casting/salt leaching, 12 gas foaming, 13 phase separation 14,15 and solid freeform fabrication 16 techniques, have been widely used. Nanoimprinting and electron beam lithography are able to precisely fabricate two-dimensional (2D) surface features, but they require long fabrication times, special apparatuses, and expensive instruments.…”

Section: Introductionmentioning

confidence: 99%

Laser-assisted biofabrication in tissue engineering and regenerative medicine

et al. 2016

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Controlling the spatial arrangement of biomaterials and living cells provides the foundation for fabricating complex biological systems. Such level of spatial resolution (less than 10 lm) is difficult to be obtained through conventional cell processing techniques, which lack the precision, reproducibility, automation, and speed required for the rapid fabrication of engineered tissue constructs. Recently, laserassisted biofabrication techniques are being intensively developed with the use of computer-aided processes for patterning and assembling both living and nonliving materials with prescribed 2D or 3D organization. In this review, we discuss laser-assisted fabrication methods, including laser tweezers, multi-photon polymerization, laser-induced forward transfer (LIFT), matrix assisted pulsed laser evaporation (MAPLE), and laser ablation as well as their applications in biological science and biomedical engineering. These advanced technologies enable the precise manipulation of in vitro cellular microenvironments and the ability to engineer functional tissue constructs with high complexity and heterogeneity, which serve in regenerative medicine, pharmacology, and basic cell biology studies.

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“…Así, la red puede considerarse constituida por un polímero Tabla 1. Límites de tolerancia de boro para cultivos (Hu et al 1996) En este contexto, al ser los poliuretanos (PUs), polímeros con propiedades ampliamente versátiles y regulables (es decir, poseen una adecuada resistencia mecánica y térmica, se les puede dar forma fácilmente y son resistentes a la biodegradación dependiendo de su síntesis) (Janik and Marzec 2015;Penagos et al 2015), son candidatos apropiados para actuar como red primaria, o soporte, en la construcción de RPIs. Por consiguiente, una RPI obtenida a partir de PUs y poli(VbNMDG) permitiría obtener un novedoso material con capacidad de retener boro y con potenciales aplicaciones en el desarrollo de dispositivos dosificadores de este micronutriente en condiciones de campo (por ej., sistemas de fertilización en columna o granular) y también podrían ser empleados en el tratamiento de aguas de riego.…”

Section: Introductionunclassified

Desarrollo de poliuretanos con capacidad de retención de boro fiodisponible

2015

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En el contexto de la fertilización de cultivos con ácido bórico (H3BO3), la utilización de materiales con capacidad de carga (retención de boro) y descarga (liberación del boro retenido), tienen potenciales aplicaciones en el desarrollo de sistemas de fertilización y en el tratamiento de aguas de riego. En el presente estudio se planteó obtener un material compuesto, basado en poliuretanos (PUs) y N-(4-vinilbencil)-N-metil-D-glucamina (VbNMDG), mediante la técnica de redes poliméricas interpenetrantes (RPIs), con potenciales aplicaciones en el desarrollo de sistemas de fertilización de boro. Para ello, diferentes matrices de PU fueron sintetizadas a partir de un isocianato (metilendifenil-isocianato, MDI) y polioles de peso molecular variable (etilenglicol, glicerol, manitol). Estos PUs fueron empleados como matriz soporte de una segunda red polimérica sintetizada a partir de la polimerización por radicales libres del VbNMDG, el cual fue sintetizado mediante sustitución nucleofílica entre el p-clorometilestireno (ClME) y la N-metil-D-glucamina (NMDG). La capacidad de retención y liberación de boro se evaluó mediante experimentos tipo batch realizándose la cuantifiación del boro remanente se hizo por el método de la azometina-H. Los resultados sugieren que las RPIs preparadas a partir de manitol poseen una mayor capacidad de retención de H3BO3 respecto a las obtenidas con etilenglicol y glicerol. Las propiedades de retención de las RPIs aumentan con el aumento de la relación R–OH/H3BO3. Se concluyó que RPIs pueden ser obtenidas a partir de PUs y poli(VbNMDG) empleando dioxano como solvente

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A review: Fabrication of porous polyurethane scaffolds

Cited by 318 publications

References 73 publications

Synthesis and structure-property relationships of biodegradable polyurethanes

Synthesis and structure-property relationships of biodegradable polyurethanes

Laser-assisted biofabrication in tissue engineering and regenerative medicine

Desarrollo de poliuretanos con capacidad de retención de boro fiodisponible

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