A review: Antihyperglycemic plant medicines in management of diabetes

Bhagour, Kiran; Arya, Dharmendra; Gupta, Radhey S.

doi:10.1016/j.arthe.2016.11.001

Cited by 14 publications

(6 citation statements)

References 26 publications

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“…Middle and western region of Saudi Arabia [80] Extracts Rhazya stricta lowered 37.9% blood glucose level in the streptozotocin-induced diabetic rats. Serum cholesterol and triglyceride levels were significantly (P < 0.05) reduced in the treated diabetic group compared to the untreated diabetic group [81] Calotropis procera Asclepiadaceae Latex Al-Kharj [82] Different extracts of C. procera at dose of 250 mg/ kg were orally administered as single dose per day to diabetes-induced rats for the period of 15 days significantly decreases blood glucose level to the level of standard drug glibenclamide [83]…”

Section: Ficus Microcarpamentioning

confidence: 99%

Bioactive Constituents and Toxicological Evaluation of Selected Antidiabetic Medicinal Plants of Saudi Arabia

Alqahtani

Ullah

Shahat

2022

Evidence-Based Complementary and Alternative Medicine

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The purpose of this review is to summarize the available antidiabetic medicinal plants in the Kingdom of Saudi Arabia with its phytoconstituents and toxicological findings supporting by the latest literature. Required data about medicinal plants having antidiabetic activities and growing in the Kingdom of Saudi Arabia were searched/collected from the online databases including Wiley, Google, PubMed, Google Scholar, ScienceDirect, and Scopus. Keywords used in search are in vivo antidiabetic activities, flora of Saudi Arabia, active ingredients, toxicological evaluations, and medicinal plants. A total of 50 plant species belonging to 27 families were found in the flora of Saudi Arabia. Dominant family was found Lamiaceae with 5 species (highest) followed by Moraceae with 4 species. β-Amyrin, β-sitosterol, stigmasterol, oleanolic acid, ursolic acid, rutin, chlorogenic acid, quercetin, and kaempferol are the very common bioactive constituents of these selected plant species. This paper has presented a list of antidiabetic plants used in the treatment of diabetes mellitus. Bioactive antidiabetic phytoconstituents which showed that these plants have hypoglycemic effects and highly recommended for further pharmacological purposes and to isolate/identify antidiabetes mellitus (anti-DM) active agents also need to investigate the side effects of active ingredients.

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Section: Ficus Microcarpamentioning

confidence: 99%

Bioactive Constituents and Toxicological Evaluation of Selected Antidiabetic Medicinal Plants of Saudi Arabia

Alqahtani

Ullah

Shahat

2022

Evidence-Based Complementary and Alternative Medicine

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“…It was clinically proven that both the compounds i.e. glycosides and aglycones play role in managing Type 2 Diabetes [40].…”

Section: Vitaminsmentioning

confidence: 99%

Just Role of Anti Diabetic Plants as Traditional Medicines

MW¹,

Raza²,

M³

et al. 2021

austinjpharmacolther

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Diabetes is one of the serious metabolic disorders occurred due to the imbalance of glucose level because of damaged pancreatic β-cells and lower production of insulin in body. Type 1 Diabetes Mellitus (TD1) and Type 2 Diabetes Mellitus (TD2) are main types of diabetes. Major portion of the world is suffering from Type 2 diabetes mellitus. Drugs used for diabetes are insulin, biguanides, sulfonylurea and inhibitors for a-glucosidase. Traditional medicines are under trial to reduce diabetic complications with no/minimum side effects. Many antidiabetic plants are under potential research i.e. strawberry, jamun, mulberry, fenugreek, turmeric, black pepper, garlic, ginger, grapefruit, and cinnamon. All of these have antidiabetic potential. These plants have bioactive compounds present in minute amounts. These compounds act against inflammation, diabetes, bacteria, fungi, other microbial infections, and obesity. These plants have antioxidant potential as well. Through HPLC “High- Performance Liquid Chromatography” screening, the compounds identified were caffeic acid, isoquercetin, kaempferol and other flavonoids. These compounds showed hypoglycemic activity. They are responsible for the increased uptake of glucose by the adipose and muscle tissues due to the activation of specific receptors i.e. PPARa “Peroxisome Proliferatoractivated Receptors a” and PPARγ (Peroxisome Proliferator-Activated Receptor γ). These activate the enzymes like glutathione, glutathione-S-transferase and catalase. Glutathione peroxidase inhibits the a-amylase then a-glucosidase lower glucose level. Effect of phytochemicals present in antidiabetic plants were studied in vitro and in vivo in animal models by inducing diabetes in them by streptozotocin, alloxan and diet on diabetic patients. Types of phytochemical compounds and their composition vary due to environmental factors, extraction and separation techniques which can have effect on clinical analysis. Bioavailability of oral drugs was also studied synergistically with these plants. Synthetic drugs, if are used with these natural compounds, they have no harmful effect but increase effectiveness. These herbal medications are more preferable, safe to use and cost effective due to which it is easily affordable by people. This review report covers the impact of these plants on diabetes mellitus reported so far.

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“…Nature is an outstanding source of antidiabetic medicines ( Chang et al, 2013 ), and plants are valuable dietary supplements to improve blood glucose control and prevent long-term complications in T2DM ( Gallagher et al, 2013 ). Folklore remedies are used for managing DM due to their non-toxic nature, cost-effectiveness, easy availability, and long-lasting effects over their synthetic counterparts ( Bhagour et al, 2016 ). Certain fruits and vegetables are functional foods, and their consumption reduces the incidence of T2DM.…”

Section: Introductionmentioning

confidence: 99%

Use of Complementary and Alternative Medicine Among Patients With Epilepsy and Diabetes Mellitus, Focusing on the Outcome of Treatment

et al. 2022

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Introduction: Millions all over the world live with epilepsy, and they may require long-term drug treatment. The use and interest in complementary and alternative medicine (CAM) have grown over the previous years. Coadministration of herbal products with medicines may result in adverse drug reactions (ADRs) and/or unfavorable interactions. The aims of this study were to determine the prevalence of CAM use among patients with epilepsy, to compare the results to those of the patients with diabetes mellitus (DM), to reveal factors that may drive the use of CAM, and to measure outcomes and adherence. It was also our intent to have state-of-the-art information on CAM use in our region among patients with the two diseases above.Materials and Methods: We conducted a non-interventional study using a self-developed questionnaire. It was distributed among adult patients with either epilepsy or DM who also suffered from cardiovascular consequences. A database was compiled from the anonymous questionnaires filled in voluntarily by the patients. Basic statistics were used to analyze this database.Results: A total of 227 questionnaires were filled in by 127 patients (55.9%) with epilepsy and 100 patients (44.1%) with DM. Mean age was 54.54 ± 17.33 years. Of the patients, 50.2% were male. Average body weight was 80.3 ± 17.3 kg. Of the patients, 22 (9.7%) used CAM because they believed in CAM. Two of them reported ADRs. Among the patients with epilepsy, the ratio was only 7.9% compared to 12% among those with DM. While the number of CAM users was higher among younger patients with epilepsy, it was the elderly patients with DM who tended to use CAM.Conclusion: Attention should be paid to reliance on CAM during the follow-up. Our finding that health-conscious patients tend to use CAM more often (than the general population) may indicate it is necessary to discuss CAM usage sincerely. CAMs modulating cytochrome P450 (CYP) enzymes were the most common, leading to interactions with medication used and resulting in ADRs. This shows the importance of educating patients and treating team including clinical pharmacists in this field.

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A review: Antihyperglycemic plant medicines in management of diabetes

Cited by 14 publications

References 26 publications

Bioactive Constituents and Toxicological Evaluation of Selected Antidiabetic Medicinal Plants of Saudi Arabia

Bioactive Constituents and Toxicological Evaluation of Selected Antidiabetic Medicinal Plants of Saudi Arabia

Just Role of Anti Diabetic Plants as Traditional Medicines

Use of Complementary and Alternative Medicine Among Patients With Epilepsy and Diabetes Mellitus, Focusing on the Outcome of Treatment

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