A Reversible Salt-wasting Syndrome of the Newborn and Infant: Possible Infantile Hypoaldosteronism

Russell, Alex; Levin, B.; Sinclair, Linda V.; Oberholzer, V. G.

doi:10.1136/adc.38.200.313

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Cited by 26 publications

(3 citation statements)

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“…Temporary salt-losing states in which the production of cortisol is unimpaired (Russell et al, 1963) have also been recognized. Visser and Cost (1964) firmly established the clinical entity of a salt-losing state due to an inborn error of aldosterone synthesis alone without impainnent of cortisol production.…”

Section: Discussionmentioning

confidence: 99%

Hypoaldosteronism in three sibs due to 18-dehydrogenase deficiency.

Hamilton¹,

McCandless²,

Ireland³

et al. 1976

Archives of Disease in Childhood

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Section: Discussionmentioning

confidence: 99%

Hypoaldosteronism in three sibs due to 18-dehydrogenase deficiency.

Hamilton¹,

McCandless²,

Ireland³

et al. 1976

Archives of Disease in Childhood

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“…Boys, however, may be overlooked, as they have either normal genitalia or bilateral cryporchidism and hypospadias. Other adrenal causes of hyponatremia, hyperkalemia and metabolic acidosis include cortisol deficiency following adrenal hemorrhage [3], transient mineralocorticoid deficiency of infancy [9], and primary pseudohypoaldosteronism [101.…”

Section: Case Reportsmentioning

confidence: 99%

Urosepsis in infants with vesicoureteral reflux masquerading as the salt-losing type of congenital adrenal hyperplasia

Vaid

Lebowitz

1989

Pediatr Radiol

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Three male infants with vomiting, dehydration, hyponatremia, hyperkalemia and metabolic acidosis were found to have vesicoureteral reflux (VUR) and urinary tract infection. Two were initially thought to have the salt-losing form of congenital adrenal hyperplasia. Although prompt diagnosis of this potentially fatal condition is critical, its mimicry by urosepsis in infants with VUR is actually more common. Infection probably causes unresponsiveness of the distal renal tubules to aldosterone.

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“…The existence of transient states of adrenocortical insufficiency in infancy were first suggested by Jaudon in 1946. Russell et al (1963 described 2 infants with a transient salt-wasting syndrome who responded well to salt-retaining hormones.…”

Section: Discussionmentioning

confidence: 99%