A reversible fluorescence chemosensor for sequentially quantitative monitoring copper and sulfide in living cells

Meng, Qingtao; Zhang, Run; Jia, Honglin; Gao, Xue; Wang, Cuiping; Shi, Yu; Everest‐Dass, Arun; Zhang, Zhiqiang

doi:10.1016/j.talanta.2015.04.072

Cited by 58 publications

(16 citation statements)

References 62 publications

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“…It can irritate the mucous membranes by intake of food or water contaminated with sulfide and even causes suffocation, unconsciousness and respiratory paralysis ,. Once sulfide anion is protonated it becomes even more toxic due to the formation of either HS − or H 2 S . Therefore, sulfide anion detection has become very important for monitoring its toxicity as well as signalling function in biological systems and the exploitation of Cu‐complexes in this domain is highly stimulating ,,…”

Section: Introductionmentioning

confidence: 99%

A Highly Selective “On‐Off‐On” Optical Switch for Sequential Detection of Cu²⁺ and S²⁻ Ions Based on 2, 6‐Diformyl‐4‐methyl Phenol and Catecholase Activity by Its Copper Complex

2018

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A new highly selective chemosensor for Cu 2 + and S 2 À ions, Ethyl 2-cyano-3-(2-hydroxy-5-methyl-3-(p-tolylimino)methyl) phenyl)acrylate) (HL) based on 2, 6-diformyl-4-methylphenol was designed and synthesized. The ligand exhibited excellent sensitivity towards copper ion by the emission quenching even in the presence of other biologically important metal ions. Once HL combine with Cu 2 + it can display a rapid response and high selectivity toward sulfide anion resulting in off-on sensing via Cu 2 + displacement assay. The signal transduction happen via reversible formation-separation of complex L-Cu and CuS and the complex LÀCu was synthesized by the reaction of HL and Cu 2 + and characterized by single-crystal Xray diffraction and DFT optimization studies. The catecholase like activity for LÀCu complex have been studied by using 3,5di-tertbutylcatechol (3,5-DTBC) as the substrate.[a] Dr.

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Section: Introductionmentioning

confidence: 99%

A Highly Selective “On‐Off‐On” Optical Switch for Sequential Detection of Cu²⁺ and S²⁻ Ions Based on 2, 6‐Diformyl‐4‐methyl Phenol and Catecholase Activity by Its Copper Complex

2018

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“…This strategy is one of the oldest utilized molecular receptor approaches for detection of analyte during diverse analytical monitoring. In this direction, Meng et al reported fluoresceinaldazine based fluorescent receptor ( Figure 6) for S 2ions in aqueous solution [8]. It displays a reversible fluorescent respose with "ON-OFF-ON" mechanism in living cells.…”

Section: Receptors Based On Complexation Reactionmentioning

confidence: 95%

Fluorescent Synthetic Receptors for Signaling Hydrogen Sulphide in Living Systems

Ma¹,

Wa²,

Ba³

et al. 2019

Biochem Anal Biochem

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In this work, we have compiled literature wherein various attempts regarding design and development of abiotic molecular receptors amid fluorescent signaling response for selective detection of various sulphur species (H 2 S, HS-, SO 3 2-S 2-) in living cells has been presented. We have specifically compiled the literature which presents the molecular systems deciphering the real-time potential for targeting mentioned chemical species under biological conditions or living cells. With regard to the chemical aspects of designed receptors, focus has been primarily diverted towards interaction of analyte with the receptor molecule at active site. The interaction driven output as a result of electronic modulation in the molecule has been discussed besides detection limit of the analyte. In addition to all this, we have also summarized the conditions for tracking of various Sulphur species in biosystems. The proposed receptors from the literature have been categorized into five classes depending on the mechanism of encounter between analyte and receptor molecule responsible for fluorescence signaling.

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“…HSip-1 shows fluorescence turn-on only to H 2 S but not biological thiols such as Cys, Hcy and GSH, and is also selective against other inorganic sulfur compounds, ROS and RNS. HSip-1 has been used to detect enzymatically produced H 2 S in buffer and cell lysate, and image intracellular H 2 S in live HeLa cells [130][131][132].…”

Section: Cu 2+mentioning

confidence: 99%

Copper-based reactions in analyte-responsive fluorescent probes for biological applications

Au‐Yeung

Chan

Tong

et al. 2017

Journal of Inorganic Biochemistry

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Copper chemistry has been capitalized on in a wide spectrum of biological events. The central importance of copper in biology lies in the diverse chemical reactivity of the redox-active transition metal ranging from electron transfer, small molecule binding and activation, to catalysis. In addition to its many different roles in natural biological systems, the diverse chemical reactivity of copper also represents a rich opportunity and resource to develop synthetic bioanalytical tools for the study of biologically important species and molecules. In this mini-review, fluorescent probes featuring a specific copper-based chemical reaction to selectively detect a biologically relevant analyte will be discussed. In particular, fluorescent probes for sensing labile copper ions, amino acids and small reactive species will be highlighted. The chemical principles, advantages and limitations of the different types of copper-mediated chemical reactions in these fluorescent probes will be emphasized.

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A reversible fluorescence chemosensor for sequentially quantitative monitoring copper and sulfide in living cells

Cited by 58 publications

References 62 publications

A Highly Selective “On‐Off‐On” Optical Switch for Sequential Detection of Cu²⁺ and S²⁻ Ions Based on 2, 6‐Diformyl‐4‐methyl Phenol and Catecholase Activity by Its Copper Complex

A Highly Selective “On‐Off‐On” Optical Switch for Sequential Detection of Cu²⁺ and S²⁻ Ions Based on 2, 6‐Diformyl‐4‐methyl Phenol and Catecholase Activity by Its Copper Complex

Fluorescent Synthetic Receptors for Signaling Hydrogen Sulphide in Living Systems

Copper-based reactions in analyte-responsive fluorescent probes for biological applications

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A reversible fluorescence chemosensor for sequentially quantitative monitoring copper and sulfide in living cells

Cited by 58 publications

References 62 publications

A Highly Selective “On‐Off‐On” Optical Switch for Sequential Detection of Cu2+ and S2− Ions Based on 2, 6‐Diformyl‐4‐methyl Phenol and Catecholase Activity by Its Copper Complex

A Highly Selective “On‐Off‐On” Optical Switch for Sequential Detection of Cu2+ and S2− Ions Based on 2, 6‐Diformyl‐4‐methyl Phenol and Catecholase Activity by Its Copper Complex

Fluorescent Synthetic Receptors for Signaling Hydrogen Sulphide in Living Systems

Copper-based reactions in analyte-responsive fluorescent probes for biological applications

Contact Info

Product

Resources

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A Highly Selective “On‐Off‐On” Optical Switch for Sequential Detection of Cu²⁺ and S²⁻ Ions Based on 2, 6‐Diformyl‐4‐methyl Phenol and Catecholase Activity by Its Copper Complex

A Highly Selective “On‐Off‐On” Optical Switch for Sequential Detection of Cu²⁺ and S²⁻ Ions Based on 2, 6‐Diformyl‐4‐methyl Phenol and Catecholase Activity by Its Copper Complex