A Reverse J-Shaped Association of All-Cause Mortality with Serum 25-Hydroxyvitamin D in General Practice: The CopD Study

Durup, Darshana; Jørgensen, Henrik L.; Christensen, Jane; Schwarz, Peter; Heegaard, Anne‐Marie; Lind, Bent

doi:10.1210/jc.2012-1176

Cited by 235 publications

(192 citation statements)

References 37 publications

Supporting

Mentioning

172

Contrasting

Unclassified

Order By: Relevance

“…Some studies have found the highest levels of 25-OHD to be associated with increasing mortality (26,54,55), but we did not find this association in our material (data not shown). This may be due to residual confounding or differences of the populations, as the DOPS women were healthy at baseline, whereas other studies have included patients referred to testing for different reasons (54) or were population based (55).…”

Section: Discussioncontrasting

confidence: 93%

See 1 more Smart Citation

Vitamin D deficiency in postmenopausal, healthy women predicts increased cardiovascular events: a 16-year follow-up study

Schierbeck

Rejnmark

Tofteng

et al. 2012

European Journal of Endocrinology

View full text Add to dashboard Cite

Objective: To investigate the relationship between vitamin D status in healthy women and cardiovascular outcome. Design and methods : Between 1990: Between and 1993: Between , 2016 healthy, recently postmenopausal women were enrolled in the Danish Osteoporosis Prevention Study. Serum levels of 25-hydroxyvitamin D (25(OH)D, nmol/l) were measured at baseline. Participants were followed for 16 years. The primary end point was a combination of death, heart failure, myocardial infarction (MI) and stroke. Vitamin D deficiency was defined as serum 25(OH)D!50 nmol/l. The primary end point was adjusted for other risk factors of adverse cardiovascular events (age, smoking, blood pressure, hip-waist ratio, education and family history of MI).

show abstract

Section: Discussioncontrasting

confidence: 93%

“…This may be due to residual confounding or differences of the populations, as the DOPS women were healthy at baseline, whereas other studies have included patients referred to testing for different reasons (54) or were population based (55). A limitation is the observational nature of this study, which makes the causality uncertain.…”

Section: Discussionmentioning

confidence: 99%

Vitamin D deficiency in postmenopausal, healthy women predicts increased cardiovascular events: a 16-year follow-up study

Schierbeck

Rejnmark

Tofteng

et al. 2012

European Journal of Endocrinology

View full text Add to dashboard Cite

show abstract

“…44 In our studies, we have never observed an event of hypercalciuria associated with vitamin D intake or circulating levels of 25(OH)D. 7,8,40,41 Concern remains about vitamin D toxicity as it relates to mortality. 45 A recent metaanalysis by Garland et al on the subject, however, clearly demonstrated increased all-cause mortality at low circulating levels with no such relationship at higher levels. 467 Finally, the levels of circulating 25(OH)D we report here are robust and consistent with levels achieved in various populations involving only solar exposure with no dietary supplementation.…”

Section: Resultsmentioning

confidence: 97%

Maternal Versus Infant Vitamin D Supplementation During Lactation: A Randomized Controlled Trial

et al. 2015

View full text Add to dashboard Cite

OBJECTIVE: Compare effectiveness of maternal vitamin D 3 supplementation with 6400 IU per day alone to maternal and infant supplementation with 400 IU per day.METHODS: Exclusively lactating women living in Charleston, SC, or Rochester, NY, at 4 to 6 weeks postpartum were randomized to either 400, 2400, or 6400 IU vitamin D 3 /day for 6 months. Breastfeeding infants in 400 IU group received oral 400 IU vitamin D 3 /day; infants in 2400 and 6400 IU groups received 0 IU/day (placebo). Vitamin D deficiency was defined as 25-hydroxy-vitamin D (25(OH)D) ,50 nmol/L. 2400 IU group ended in 2009 as greater infant deficiency occurred. Maternal serum vitamin D, 25(OH)D, calcium, and phosphorus concentrations and urinary calcium/creatinine ratios were measured at baseline then monthly, and infant blood parameters were measured at baseline and months 4 and 7.RESULTS: Of the 334 mother-infant pairs in 400 IU and 6400 IU groups at enrollment, 216 (64.7%) were still breastfeeding at visit 1; 148 (44.3%) continued full breastfeeding to 4 months and 95 (28.4%) to 7 months. Vitamin D deficiency in breastfeeding infants was greatly affected by race. Compared with 400 IU vitamin D 3 per day, 6400 IU/day safely and significantly increased maternal vitamin D and 25(OH)D from baseline (P , .0001). Compared with breastfeeding infant 25(OH)D in the 400 IU group receiving supplement, infants in the 6400 IU group whose mothers only received supplement did not differ. CONCLUSIONS:Maternal vitamin D supplementation with 6400 IU/day safely supplies breast milk with adequate vitamin D to satisfy her nursing infant's requirement and offers an alternate strategy to direct infant supplementation. WHAT'S KNOWN ON THIS SUBJECT:The vitamin D concentration in breast milk of women taking 400 IU vitamin D per day is relatively low, leading to vitamin D deficiency in breastfeeding infants. As a result, the American Academy of Pediatrics recommends breastfeeding infant vitamin D supplementation within days after birth. WHAT THIS STUDY ADDS:Maternal vitamin D supplementation alone with 6400 IU/day safely supplies breast milk with adequate vitamin D to satisfy the requirement of her nursing infant and offers an alternate strategy to direct infant supplementation. Dr Hollis, as the principal investigator (PI) of the project, worked with Dr Wagner in the conception of the project, study design, implementation of the study, laboratory analyses, data analyses, and writing of the manuscript; Dr, Wagner as clinical PI of the study, worked with Drs Hollis and Howard, site PI at the University of Rochester (U of R), and all other coinvestigators in the conception of the project, study design, implementation of the study, review of clinical and laboratory data, subject safety, data analyses, and writing of the manuscript; Dr Howard as clinical site PI at the U of R worked directly with Dr Wagner; she was involved in the conception of the project, study design, implementation of the study, laboratory analyses, data analyses, and writing of the manuscript; M...

show abstract

“…Most of these studies 8 indicated a linear association such that highest concentrations were related to the lowest risk. 9 However, in the largest cohort study so far among almost 250,000 Danish men and women, both low 10 (≤ 10 nmol/L) and high (≥ 140 nmol/L) concentrations compared with 50-60 nmol/L were related to 11 increased all-cause mortality [6]. 12 In a recent study, an effect of vitamin D concentration on short term mortality was shown.…”

Section: Introductionmentioning

confidence: 99%

Inverse association between circulating vitamin D and mortality – Dependent on sex and cause of death?

Rohrmann

Braun

Bopp

et al. 2013

Nutrition, Metabolism and Cardiovascular Diseases

View full text Add to dashboard Cite

A Reverse J-Shaped Association of All-Cause Mortality with Serum 25-Hydroxyvitamin D in General Practice: The CopD Study

Cited by 235 publications

References 37 publications

Vitamin D deficiency in postmenopausal, healthy women predicts increased cardiovascular events: a 16-year follow-up study

Vitamin D deficiency in postmenopausal, healthy women predicts increased cardiovascular events: a 16-year follow-up study

Maternal Versus Infant Vitamin D Supplementation During Lactation: A Randomized Controlled Trial

Inverse association between circulating vitamin D and mortality – Dependent on sex and cause of death?

Contact Info

Product

Resources

About