A retroviral insertion in the tyrosinase (TYR) gene is associated with the recessive white plumage color in the Yeonsan Ogye chicken

Cho, Eunjin; Kim, Minjun; Manjula, Prabuddha; Cho, Sung Hyun; Seo, Dongwon; Lee, Seung-Sook; Lee, Jun Heon

doi:10.5187/jast.2021.e71

Cited by 11 publications

(9 citation statements)

References 31 publications

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“…TYR encodes tyrosinase, the rate-limiting enzyme in melanin synthesis ( Sturm, 2009 ; Yang et al., 2019 ; Seruggia et al., 2021 ; Varghese et al, 2021 ). A retroviral insertion into the fourth intron of the TYR gene in chickens leads to impaired tyrosinase expression and the production of recessive white feathers ( Chang et al., 2006 ; Cho et al., 2021 ). One significant SNP (Chr1:188181166 G>C) located in the first exon of RAB38 , which is a missense mutation.…”

Section: Resultsmentioning

confidence: 99%

Genomic insights into local adaptation and phenotypic diversity of Wenchang chickens

Gu,

Wu,

Zheng

et al. 2024

Poultry Science

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Section: Resultsmentioning

confidence: 99%

Genomic insights into local adaptation and phenotypic diversity of Wenchang chickens

Gu,

Wu,

Zheng

et al. 2024

Poultry Science

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“…TYR is the rate-limiting enzyme and key enzyme for melanin synthesis ( Bajpai et al, 2023 ). Cho et al (2021) conducted molecular analysis of TYR and found that abnormal transcription of TYR leads to the recessive white feather phenotype. The differential expression of key genes suggests that they may be the underlying reasons for feather color differentiation in Lueyang black-bone chicken.…”

Section: Discussionmentioning

confidence: 99%

A single-cell transcriptome atlas of Lueyang black-bone chicken skin

Wang,

Xue,

Tian

et al. 2024

Poultry Science

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“…Differences in the plumage and skin color of chickens may be caused by the differential expression of the TYR gene. The retroviral insertion of the tyrosinase gene ( TYR ) has been associated with recessive white mutations in chickens [ 31 ]. Nam et al [ 32 ] found, in a study on Korean native chickens, that specific mutations in the TYR gene can have important effects on melanosis in Korean native chickens.…”

Section: Discussionmentioning

confidence: 99%

Transcriptome Profile Analysis Identifies Candidate Genes for the Melanin Pigmentation of Skin in Tengchong Snow Chickens

Ge²,

Zhu

et al. 2023

Veterinary Sciences

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Tengchong Snow chickens are one of the most precious, black-boned chickens in Yunnan province and usually produce black meat. However, we found a small number of white meat traits in the chicken population during feeding. In order to determine the pattern of melanin deposition and the molecular mechanism of formation in the Tengchong Snow chicken, we measured the luminance value (L value) and melanin content in the skin of black meat chickens (Bc) and white meat chickens (Wc) using a color colorimeter, ELISA kit, and enzyme marker. The results showed that the L value of skin tissues in black meat chickens was significantly lower than that of white meat chickens, and the L value of skin tissues gradually increased with an increase in age. The melanin content of skin tissues in black meat chickens was higher than that of white meat chickens, and melanin content in the skin tissues gradually decreased with an increase in age, but this difference was not significant (p > 0.05); the L value of skin tissues in black meat chickens was negatively correlated with melanin content, and the correlation coefficient was mostly above −0.6. In addition, based on the phenotypic results, we chose to perform the comparative transcriptome profiling of skin tissues at 90 days of age. We screened a total of 44 differential genes, of which 32 were upregulated and 12 were downregulated. These DEGs were mainly involved in melanogenesis, tyrosine metabolism and RNA transport. We identified TYR, DCT, and EDNRB2 as possible master effector genes for skin pigmentation in Tengchong Snow black meat chickens through DEGs analysis. Finally, we measured the mRNA of TYR, DCT, MC1R, EDNRB2, GPR143, MITF, and TYRP1 genes through a quantitative real-time polymerase chain reaction (qPCR) and found that the mRNA of all the above seven genes decreased with increasing age. In conclusion, our study initially constructed an evaluation system for the black-boned traits of Tengchong Snow chickens and found key candidate genes regulating melanin deposition, which could provide an important theoretical basis for the selection and breeding of black-boned chickens.

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A retroviral insertion in the tyrosinase (TYR) gene is associated with the recessive white plumage color in the Yeonsan Ogye chicken

Abstract: Competing interestsNo potential conflict of interest relevant to this article was reported. Funding sourcesState funding sources (grants, funding sources, equipment, and supplies). Include name and number of grant if available.Not applicable.

Cited by 11 publications

References 31 publications

Genomic insights into local adaptation and phenotypic diversity of Wenchang chickens

Genomic insights into local adaptation and phenotypic diversity of Wenchang chickens

A single-cell transcriptome atlas of Lueyang black-bone chicken skin

Transcriptome Profile Analysis Identifies Candidate Genes for the Melanin Pigmentation of Skin in Tengchong Snow Chickens

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