A Retrospective Study to Assess the Effect of Proton Pump Inhibitors on Renal Profile in a South Indian Hospital

Aujayeb, Avinash; Patil, Navin; Kunder, Sushil Kiran; Balaji, O; Tilak, Amod; Sori, Ravi K; Rao, Raghavendra

doi:10.7860/jcdr/2017/26097.9752

Cited by 3 publications

(4 citation statements)

References 26 publications

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“…19,21 Other authors showed similar results that male patients are more vulnerable to renal diseases. 20,22 Also in this study, it was observed that 56% patients were males and 44% were females. This shows that male patients are more prone to renal dysfunction than female patients.…”

Section: Discussionsupporting

confidence: 52%

“…[13][14][15][16][17][18][19] Gulipalli Sowjanya et al also showed that patients within the age group of 56-60 years are at higher risk of renal diseases. [20][21][22][23][24][25][26][27] Arora et al cohort study reported that younger individuals were more likely to develop CKD associated with PPIs use. 28 In this study, the patients were in the age group of 18-75 years with a mean age of 55.5 years.…”

Section: Discussionmentioning

confidence: 99%

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Association of proton pump inhibitors with renal dysfunction: a cross-sectional study

Singh,

Bala,

Jain

et al. 2023

Int J Basic Clin Pharmacol

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Background: Proton pump inhibitors are the most frequently prescribed class of medications for prescription and over-the-counter, and the data suggest that comorbidities, polypharmacy, self-medication, no clear indications and duration beyond the recommended guidelines PPIs use are associated with renal dysfunction. Aim was to study the proportion of renal dysfunction among patients using oral PPIs and determine the association between the duration of oral PPIs use and the severity of renal dysfunction. Methods: The data collection of 250 patients was done at the time of contact, which included demographic profiles, complete medical history, physical examination, and laboratory investigation in this study. For analysis, name of oral PPIs used, duration and dosage of oral PPIs therapy, laboratory values of serum blood urea, serum creatinine, eGFR, and serum electrolytes parameters have been considered. Results: Amongst 250 patients with PPIs used for a week, 23 patients showed mildly reduced kidney function (p=0.000), PPIs used for >1 to 2 weeks, 29 patients showed grade 2 kidney function (p=0.001), while PPIs used for >2-3 weeks only two patients showed grade 3 kidney function (p=0.44). Patients aged >50 years in all groups showed grade 2 renal function, regardless of the duration of PPIs use. Increasing age, males, rural, smoking, and alcoholics were the risk factors for renal dysfunction. PPIs use significantly impacts eGFR. Conclusions: Collectively, this study found a significant association between PPIs use and renal dysfunction. PPIs used for >2 weeks in elderly patients have shown a 4−fold increased risk of developing renal dysfunction.

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Section: Discussionsupporting

confidence: 52%

Section: Discussionmentioning

confidence: 99%

Association of proton pump inhibitors with renal dysfunction: a cross-sectional study

Singh,

Bala,

Jain

et al. 2023

Int J Basic Clin Pharmacol

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“…The mean duration of exposure to pantoprazole prior to the onset of acute kidney injury is 3 months, although it has also been reported to occur within hours of pantoprazole administration ( 23 ). The symptoms of acute kidney injury are generally nonspecific, for instance fatigue and malaise ( 24 ). Acute renal failure is the only consistent clinical presentation, although oliguria is unusual ( 24 ).…”

Section: Discussionmentioning

confidence: 99%

“…The symptoms of acute kidney injury are generally nonspecific, for instance fatigue and malaise ( 24 ). Acute renal failure is the only consistent clinical presentation, although oliguria is unusual ( 24 ). Nausea and vomiting are present in 1/3 of cases ( 25 ).…”

Section: Discussionmentioning

confidence: 99%

Pantoprazole‑induced acute kidney injury: A case report

Peng

Zheng³

et al. 2018

Exp Ther Med

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The present study reports a case of pantoprazole-induced acute kidney disease. The patient was diagnosed with acute kidney injury with wide interstitial inflammation and eosinophil infiltration. Following 1 month of glucocorticoid therapy, the patient's serum creatinine and urea nitrogen decreased to within normal ranges. The presentation, clinical course, diagnosis and prognosis of pantoprazole-induced acute kidney injury are discussed herein to highlight the importance of early and correct diagnosis for good prognosis. Disease characteristics include short-term increased serum creatinine levels that respond to glucocorticoid treatment. The patient had no history of chronic kidney disease or proteinuria and presented with increased serum creatinine following treatment with pantoprazole. Following the end of pantoprazole treatment, short-term RRT and long-term prednisolone was administered, then serum creatinine returned to normal. Pantoprazole-induced acute kidney injury is commonly misdiagnosed and late diagnosis results in poor patient prognoses. Misdiagnosis leads to the administration of treatments that may exacerbate the condition, so appropriate diagnosis and treatment for pantoprazole-induced acute kidney injury is necessary.

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Assessment of the risk of acute kidney injury associated with the use of pantoprazole and esomeprazole

Prasad

Chettri

Rajesh

et al. 2018

Drugs Ther Perspect

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A Retrospective Study to Assess the Effect of Proton Pump Inhibitors on Renal Profile in a South Indian Hospital

Abstract: PPIs are not entirely free of adverse effects, as assumed by several practitioners. A vigilant eye has to be maintained on the patient's renal profile so as to avoid any untoward decline in renal function, as evidenced in the current study.

Cited by 3 publications

References 26 publications

Association of proton pump inhibitors with renal dysfunction: a cross-sectional study

Association of proton pump inhibitors with renal dysfunction: a cross-sectional study

Pantoprazole‑induced acute kidney injury: A case report

Assessment of the risk of acute kidney injury associated with the use of pantoprazole and esomeprazole

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