A retrospective study on the effects of pulmonary rehabilitation in patients with pulmonary hypertension

Raskin, Jonathan; Qua, Deborah; Marks, Ted; Sulica, Roxanne

doi:10.1177/1479972314538980

Cited by 17 publications

(16 citation statements)

References 34 publications

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“…This result was confirmed by a retrospective study, which also showed a significant improvement by exercise training, with a higher benefit for those patients who had lower 6MWD at baseline [30]. …”

Section: Clinical Effects Of Exercise Training On Phsupporting

confidence: 66%

Principles of Rehabilitation and Reactivation: Pulmonary Hypertension

et al. 2015

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Most recently, a specialized and carefully monitored exercise training and rehabilitation program has been recommended as add-on to medical treatment in patients with pulmonary arterial hypertension (class I, level of evidence A). Three prospective randomized, controlled trials, 10 prospective uncontrolled trials, 2 retrospective studies and 2 case series in more than 470 patients with severe pulmonary hypertension (PH) and right heart failure reported beneficial effects of a specialized exercise training and rehabilitation program, i.e. significant improvement in symptoms, exercise capacity, cardiorespiratory function and quality of life, compared with untrained controls. All training studies reported an acceptable safety profile, and some uncontrolled studies showed excellent 1- and 2-year survival rates. However, most studies had a quite small sample size (ranging from 2 to 183 patients) and an uncontrolled design, and they were not designed to assess hemodynamic changes, time to clinical worsening and survival. Nevertheless, there is large evidence that exercise training programs should be performed by centers experienced in both PH patient care and rehabilitation. The best method and duration of the training, characteristics of supervision, and the mechanisms resulting in symptom improvement and increased functional capacity are unclear. In this review, we summarize data of molecular and clinical effects of exercise training in PH patients. Furthermore, we discuss safety data and the role of a self-care management of exercise training in these patients.

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Section: Clinical Effects Of Exercise Training On Phsupporting

confidence: 66%

Principles of Rehabilitation and Reactivation: Pulmonary Hypertension

et al. 2015

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“…16 Eighteen studies were included in this review. All Englishlanguage articles of adults with PH were retrieved and considered.…”

Section: Search Methodsmentioning

confidence: 99%

The benefit of exercise training in pulmonary hypertension: a clinical review

Chia

Wong

Faux

et al. 2017

Internal Medicine Journal

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Pulmonary hypertension (PH) is a clinical condition characterised by raised pulmonary artery pressure, which results in increased right ventricular afterload and dyspnoea. This is accompanied by reduced exercise capacity, quality of life and, eventually, death. An increasing range of targeted medications has transformed the treatment of pulmonary arterial hypertension, a specific type of PH. Supervised exercise training is recommended as part of a multifaceted management plan for PH. However, many questions remain regarding how exercise training improves exercise capacity and quality of life. The optimal exercise regimen (frequency, timing, duration and intensity) also remains unclear. This review provides an update on the pathophysiology of exercise impairment in PH, suggests mechanisms by which exercise may improve symptoms and function and offers evidence-based recommendations regarding the frequency and intensity of an exercise programme for patients with PH.

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“…[3][4][5] Moreover, patients often experience a significant decrease in their physical capacity and quality of life (QoL). [10][11][12] Exercise capacity is often evaluated with 6-minute walk test (6MWT) which exercise testing represents daily life physical activity (DLPA). [10][11][12] Exercise capacity is often evaluated with 6-minute walk test (6MWT) which exercise testing represents daily life physical activity (DLPA).…”

Section: Introductionmentioning

confidence: 99%