A Retrospective Study on the Effect of Herbal Extracts Combined with Conventional Therapy on Blood Glucose in Type 2 Diabetes Mellitus

정, 수민; 노, 지원; 이, 민승; 양, 희권; 안, 영민; 안, 세영; 이, 병철

doi:10.22246/jikm.2020.41.6.1231

Cited by 3 publications

(2 citation statements)

References 10 publications

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“…Herbal medicines have been traditionally used and have received considerable attention as important agents for treating and preventing cardiovascular diseases such as atherosclerosis [7,8]. As a representative herbal medicine, Daeshiho-tang (DSHT) has been used in Korea for its preventive and treatment effects on diabetes [9], hepatotoxicity [10], hypertension, arterial constriction [11], and inflammatory reactions. DSHT is an herbal medicine that consists of six ingredients.…”

Section: Introductionmentioning

confidence: 99%

Daeshiho-tang Attenuates Atherosclerosis by Regulating Cholesterol Metabolism and Inducing M2 Macrophage Polarization

Song

Cho

Lee

et al. 2022

Life

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Dyslipidemia, the commonest cause of cardiovascular disease, leads to lipid deposits on the arterial wall, thereby aggravating atherosclerosis. DSHT (Daeshiho-tang) has long been used as an anti-dyslipidemia agent in oriental medicine. However, the anti-atherosclerotic effects of DSHT have not been fully investigated. Therefore, this study was designed to evaluate whether DSHT could exert beneficial anti-atherosclerotic effects. We fed apolipoprotein E-deficient (ApoE-/-) mice on a high-fat diet and treated them with atorvastatin (AT) or DSHT, or the combination of DSHT and AT for 12 weeks. To determine the role of DSHT, atherosclerotic lesions in the aorta, aortic root, and aortic arch; lipids and apolipoprotein levels in serum; and macrophage polarization markers in aorta tissues were examined. We show here that the DSHT decreased the atherosclerotic plaque ratio in the aortic arch, aorta, and aortic root. DSHT also regulated lipid levels by decreasing the ApoB level and increasing the ApoA1 level. Moreover, DSHT effectively regulated cholesterol metabolism by increasing the levels of PPARγ, ABCA1 and ABCG1, and the LDL receptor genes. We further found that DSHT promoted polarization to the M2 phenotype by increasing the levels of M2 macrophage (ARG1, CD163, and PPARγ) markers. Our data suggested that DSHT enhances the anti-atherosclerotic effect by regulating cholesterol metabolism through the activation of the PPARγ signaling pathway and by promoting anti-inflammatory M2 macrophage polarization.

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Section: Introductionmentioning

confidence: 99%

Daeshiho-tang Attenuates Atherosclerosis by Regulating Cholesterol Metabolism and Inducing M2 Macrophage Polarization

Song

Cho

Lee

et al. 2022

Life

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“…Additionally, Jeong reported that fasting and postprandial blood glucose levels were improved by the administration of Jowiseunggi-tang, Dashiho-tang, Bojungikgi-tang, and Hoechunyanggyeok-san to patients with type 2 diabetes presenting with thirst and frequent urination. [6] Geumguesingi-hwan (GSH), in which Rehmannia radix is a principal medicine, is a prescription used to improve various symptoms caused by Yang deficiency syndrome in the kidney. [7] A meta-analysis published by Chen provided clinical evidence regarding the antidiabetic effects of GSH in patients with type 2 diabetes mellitus showing diabetic neuropathy.…”

Section: Introductionmentioning

confidence: 99%

Efficacy of Geumguesingi-hwan (jinkuishenqi-wan, kinkijinki-gan) in decreasing blood glucose levels in patients with uncomplicated type 2 diabetes

et al. 2022

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Background: The purpose of a systematic review and meta-analysis is to verify the clinical efficacy and safety of Geumguesingihwan for patients with uncomplicated type 2 diabetes.Methods: The systematic review and meta-analysis will be performed following the guidelines of the National Evidence-based Healthcare Collaborating Agency. We will conduct a systematic search of randomized controlled trials in 8 electronic databases until August 31, 2021.Results: This study will provide evidence regarding the clinical efficacy of Geumguesingi-hwan from the following 3 perspectives: improving blood glucose level, insulin resistance, and b-cell function. Additionally, we will examine the safety of Geumguesingi-hwan by evaluating the adverse effects.Conclusions: This study will verify the antidiabetic efficacy and safety of Geumguesingi-hwan in patients with uncomplicated type 2 diabetes.

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A Retrospective Study of the Safety and Effect of Co-administration of Glucose-lowering Medication and <italic>Bojungikgi-tang</italic> on Blood Glucose Level in Patients with Type 2 Diabetes Mellitus

Oh¹,

Jung²,

Song³

et al. 2023

J Int Korean Med

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Objective: This study aimed to assess the safety and effect on glucose level of Bojungikgi-tang in patients with type 2 diabetes mellitus.Methods: To review patients’ clinical characteristics and laboratory tests retrospectively, we investigated 15 hospitalized patients with type 2 diabetes mellitus who took Bojungikgi-tang at Kyung Hee University Korean Medical Hospital for at least one day between January 2012 and December 2022. The blood glucose levels, including fasting blood sugar (FBS), 2-hour postprandial glucose (PP2) levels, and glycated hemoglobin level, were collected to determine the effect of the Bojungikgi-tang on blood sugar changes. Furthermore, to evaluate the safety of Bojungikgi-tang, hepatic function and renal function tests were implemented, including aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, γ-glutamyltransferase, blood urea nitrogen, creatinine, and Modification of Diet in Renal Disease estimated glomerular filtration rate.Results: When Bojungikgi-tang and a standard treatment for diabetes were administered for patients with type 2 diabetes, it was confirmed that there were no statistically significant changes in FBS and PP2 levels in the analysis of each medication taken. There was no significant difference in the safety profile after taking Bojungikgi-tang.Conclusions: The combined administration of Bojungikgi-tang with standard hypoglycemic medication for patients with type 2 diabetes may not affect blood glucose levels and safety.

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A Retrospective Study on the Effect of Herbal Extracts Combined with Conventional Therapy on Blood Glucose in Type 2 Diabetes Mellitus

Cited by 3 publications

References 10 publications

Daeshiho-tang Attenuates Atherosclerosis by Regulating Cholesterol Metabolism and Inducing M2 Macrophage Polarization

Daeshiho-tang Attenuates Atherosclerosis by Regulating Cholesterol Metabolism and Inducing M2 Macrophage Polarization

Efficacy of Geumguesingi-hwan (jinkuishenqi-wan, kinkijinki-gan) in decreasing blood glucose levels in patients with uncomplicated type 2 diabetes

A Retrospective Study of the Safety and Effect of Co-administration of Glucose-lowering Medication and <italic>Bojungikgi-tang</italic> on Blood Glucose Level in Patients with Type 2 Diabetes Mellitus

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