A retrospective study on the effects of colistin therapy in children with multidrug-resistant Gram-negative bacterial pathogens: impact of HIV status on outcome

Dimitriades, Konstantinos; Morrow, Brenda; Jeena, Prakash

doi:10.1136/archdischild-2013-304540

Cited by 6 publications

(3 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These organisms are common nosocomial microbes. 5 Similarly, a study on colistin usage in neonates in Turkey, by Cağan et al, 9 found that the most frequently isolated pathogens were K. pneumoniae and A. baumannii followed by P. aeruginosa and E. cloacae. The same study reported that patients treated with colistin were treated with at least one other antibiotic, a finding that is mirrored in this study.…”

Section: Discussionmentioning

confidence: 96%

“…3,4 Microbial resistance to antibiotic classes such as cephalosporins, aminoglycosides, quinolones and carbapenems has contributed to an increase in the use of colistin globally. 5 In South Africa (SA), colistin is used as salvage therapy for life-threatening infections, 1,2 especially where resistance to the carbapenem class of antibiotics has been observed. 6 The carbapenems have been considered to be part of the last line of defence against MDR gram-negative bacterial infections.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

A retrospective review of colistin utilisation at a tertiary care academic hospital in South Africa

Majavie

Johnston

Messina³

2021

Southern African Journal of Infectious Diseases

View full text Add to dashboard Cite

Background: The use of the antibiotic colistin was increasing as a treatment option for multidrug-resistant (MDR) infections. Standardisation of colistin dosing and more appropriate record-keeping practices were required to fully assess the optimal usage of colistin. The aim of this study was to determine how and why colistin was used in the treatment of MDR infections in a tertiary care public hospital in South Africa (SA). Methods: This cross-sectional retrospective record review described adult and paediatric patients who received colistin intravenously from 01 May 2016 to 31 April 2017. Information from patient records were captured on a data collection tool and analysed using descriptive statistics. Ethical approval was obtained from the Human Research Ethics Committee of the University of the Witwatersrand.Results: A total of 43 patient records were reviewed. Acinetobacter baumannii was the most common organism isolated (85.2% adults and 62.5% paediatrics). Colistin was mostly prescribed for sepsis (18 adults and 15 paediatrics). Most adults (66.7%) received loading doses as recommended; however, there was a great variation in maintenance doses. Paediatric patients reviewed also showed varying dosing according to weight. The mean duration of colistin therapy was 10 days. Carbapenems were most commonly co-administered with colistin (58%). Conclusion:The findings suggested that although colistin usage was restricted in the hospital, it was not adequately monitored or controlled. Doses prescribed were made at the discretion of prescribing doctors and differed to currently accepted guidelines. Improved record-keeping practices related to the monitoring of colistin use were required.

show abstract

Section: Discussionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

A retrospective review of colistin utilisation at a tertiary care academic hospital in South Africa

Majavie

Johnston

Messina³

2021

Southern African Journal of Infectious Diseases

View full text Add to dashboard Cite

show abstract

“…Although limited studies have evaluated safety and efficacy of colistin in pediatrics and neonates, the results were promising [74][75][76]. Response rate of 53-87.5% were noted in pediatric and neonatal studies.…”

Section: Neonates and Pediatricsmentioning

confidence: 81%

Colistin: efficacy and safety in different populations

Shahbazi

Dashti‐Khavidaki

2015

Expert Review of Clinical Pharmacology

View full text Add to dashboard Cite

This article reviews mechanisms, incidences, risk factors and preventive modalities of colistin toxicity as well as colistin use in special populations and through special routes. All clinical studies that examined the pharmacokinetic/pharmacodynamic, efficacy and side effects of colistin in the management of multidrug-resistant organisms in different patient population including pediatrics, adults, obese, critically ill, burn or cancer patients with any route of drug administration were considered. Compared with older recommended doses, current dosing approach improves cure rate without significant increase in the rate of colistin-induced nephrotoxicity. Efficacy and safety of high doses of colistin should be considered in the future studies. Also comparing efficacy and safety of different doses of aerosolized colistin and defining the appropriate dose in different populations is another open area of future researches.

show abstract

Systematic review on estimated rates of nephrotoxicity and neurotoxicity in patients treated with polymyxins

Wagenlehner

Lucenteforte

Pea

et al. 2021

Clinical Microbiology and Infection

View full text Add to dashboard Cite

A retrospective study on the effects of colistin therapy in children with multidrug-resistant Gram-negative bacterial pathogens: impact of HIV status on outcome

Cited by 6 publications

References 26 publications

A retrospective review of colistin utilisation at a tertiary care academic hospital in South Africa

A retrospective review of colistin utilisation at a tertiary care academic hospital in South Africa

Colistin: efficacy and safety in different populations

Systematic review on estimated rates of nephrotoxicity and neurotoxicity in patients treated with polymyxins

Contact Info

Product

Resources

About