A retrospective study on the use of oral morphine in cancer pain

Ventafridda, Vittorio; Oliveri, E.; Caraceni, Augusto; Spoldi, E.; Conno, F. De; Saita, L.; Ripamonti, Carla

doi:10.1016/s0885-3924(87)80019-2

Cited by 46 publications

(10 citation statements)

References 8 publications

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“…1) Morphine has several pharmacological actions in addition to its analgesic action and, therefore, many adverse eŠects such as constipation, nausea, vomiting and drowsiness. 2,3) These adverse eŠects can cause patients to stop taking morphine. Constipation is a serious side eŠect that frequently occurs soon after morphine administration.…”

Section: Effect Of Dietary Fiber On Morphine-induced Constipation In mentioning

confidence: 99%

Effect of Dietary Fiber on Morphine-induced Constipation in Rats

Niwa¹,

Nakao²,

Hoshi³

et al. 2002

Bioscience, Biotechnology, and Biochemistry

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Morphine is used to alleviate chronic cancer pain. However, constipation is a major adverse effect that often detracts from the patient's quality of life. In this study, we investigated the effectiveness of dietary fiber on morphine-induced constipation. Rats were fed on a normal diet or one containing either 10% or 20% apple fiber for two weeks before morphine was administered. In the control diet group, the fecal number and dry weight were decreased by treating with morphine in a dose-dependent manner. Moreover, the motility of the small and large intestines was reduced. The fecal number and weight were increased and the colon motility was promoted by dietary fiber, regardless of whether morphine was being administered. The dietary fiber increased the concentration of short-chain fatty acids (SCFAs) in the cecum. These results suggest that dietary fiber has a preventative effect on morphine-induced constipation by increasing SCFAs in the cecum, and thereby promoting colon motility in rats.

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Section: Effect Of Dietary Fiber On Morphine-induced Constipation In mentioning

confidence: 99%

Effect of Dietary Fiber on Morphine-induced Constipation in Rats

Niwa¹,

Nakao²,

Hoshi³

et al. 2002

Bioscience, Biotechnology, and Biochemistry

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“…Moreover, the World Health Organisation (WHO) introduced a pain ladder [16] in 1986 that has been accepted worldwide. Combined with appropriate dosage guidelines, it should be able to provide tools for adequate pain relief in 70%-90% of the patients [17][18][19][20][21][22].…”

Section: Introductionmentioning

confidence: 99%

Prevalence of pain in patients with cancer: a systematic review of the past 40 years

Everdingen

Rijke

Kessels³

et al. 2007

Annals of Oncology

1,618

859

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Background: Despite the abundant literature on this topic, accurate prevalence estimates of pain in cancer patients are not available. We investigated the prevalence of pain in cancer patients according to the different disease stages and types of cancer.Patients and methods: A systematic review of the literature was conducted. An instrument especially designed for judging prevalence studies on their methodological quality was used. Methodologically acceptable articles were used in the meta-analyses.Results: Fifty-two studies were used in the meta-analysis. Pooled prevalence rates of pain were calculated for four subgroups: (i) studies including patients after curative treatment, 33% [95% confidence interval (CI) 21% to 46%]; (ii) studies including patients under anticancer treatment: 59% (CI 44% to 73%); (iii) studies including patients characterised as advanced/metastatic/terminal disease, 64% (CI 58% to 69%) and (iii) studies including patients at all disease stages, 53% (CI 43% to 63%). Of the patients with pain more than one-third graded their pain as moderate or severe. Pooled prevalence of pain was >50% in all cancer types with the highest prevalence in head/neck cancer patients (70%; 95% CI 51% to 88%). Conclusion:Despite the clear World Health Organisation recommendations, cancer pain still is a major problem.

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“…In der größten Studie mit insgesamt 12.000 Patienten (Porter u. Jick 1980) wurde unter kontinuierlicher Opioidgabe bei nur 4 Patienten (=0,03%) eine psychische Abhängigkeit nachgewiesen. In anderen gut dokumentierten Untersuchungen ließ sich bei keinem Patienten eine psychische Abhängigkeit feststellen (Sorge et al 1990, Ventafridda et al 1987, Walsh 1984, Zenz et al 1989. In einigen wenigen Arbeiten werden zwar höhere Abhängigkeitsraten genannt (Tennant et al 1988, Wan Lu et al 1988), die jedoch eindeutig auf Unterdosierungen, diskontinuierliche Opioidga-be oder auf eine unzureichende Differenzierung von psychischer und physischer Abhängigkeit zurückzuführen sind."…”

Section: Zenz U Jurna: Lehrbuch Der Schmerztherapieunclassified

Keine Opioidabhängigkeit bei Schmerzpatienten?

Mindach¹

2000

Der Schmerz

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A retrospective study on the use of oral morphine in cancer pain

Cited by 46 publications

References 8 publications

Effect of Dietary Fiber on Morphine-induced Constipation in Rats

Effect of Dietary Fiber on Morphine-induced Constipation in Rats

Prevalence of pain in patients with cancer: a systematic review of the past 40 years

Keine Opioidabhängigkeit bei Schmerzpatienten?

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