A retrospective study of SPECT/CT scans using SUV measurement of the normal pelvis with Tc-99m methylene diphosphonate

Wang, Ruifeng; Duan, Xiaoyi; Cong, Shan; Han, Dong; Ma, Jun; Wu, Hulin; Xu, Xiangdong; Qin, Tao; Fan, Quli; Zhang, Zhaoguo; Shi, Weihua; Guo, Youmin

doi:10.3233/xst-180391

Cited by 11 publications

(14 citation statements)

References 23 publications

(13 reference statements)

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“…Bone mineral density (BMD) obtained through dual X-ray absorptiometry (DEXA) is the gold standard and previous studies showed a significant positive correlation between HU and BMD [23] [24]. By analyzing the correlation between CT value and SUV, we found that SUVmax of each vertebral segment had a negatively strong correlation with the CT value (HU), which is contrary to the results of previous studies [20][25] [26],those only analyzed the relationship between SUVmax and CT value of lumbar vertebrae while the gravity and blood supply of vertebral bodies were consistent. Different from previous studies, we analyzed the relationship between SUVmax and CT value of all vertebral body segments.SUVmax of 99mTc-MDP in bone is often associated with blood supply and bone mineral density [27].…”

Section: Discussioncontrasting

confidence: 77%

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Establishment of the Standardized Uptake Values of 99mTc-MDP in Normal Vertebrae for SPECT/CT Quantification

Qi¹,

Meng²,

Zhi-wen³

et al. 2020

Preprint

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PurposeTo establish the standardized uptake value (SUV) of Tc-99m-methylene diphosphonate (MDP) for normal vertebra in both Chinese male and female by using a SPECT/CT scanner.MethodsA retrospective study was carried out involving 116 men and 105 women who underwent SPECT/CT scan using 99mTc-MDP. We acquired the SUV, CT value of 2416 normal vertebra in total and analyzed the difference of SUV between men and women. We analyzed the vertebra data with no significant difference of SUVmax in male and female group. The correlations between SUVmax value and CT value, age, height, weight in each group were also analyzed.ResultsThe SUVmax, SUVmean of vertebra in men were markedly higher than those in women(P < 0.0009). Specifically, for males, the SUVmax of C1, C2-4 and C5-L5 vertebra appeared to have significant differences(P < 0.05), while no significant difference of the SUVmax of C1-L5 vertebra were observed in females(P < 0.05). The SUVmax of each vertebral segment showed a strong negative correlation with CT values in both men and women(r=-0.89,-0.92;P < 0.0009). The SUVmax of vertebra showed weak significant correlation with weight and height in male (r = 0.4,P < 0.0009;r = 0.28,P = 0.005),and weak significant correlation with weight in females(r = 0.32,P = 0.009).ConclusionThis article study initially established SUVmax, SUVavgmean of normal vertebra in both Chinese men and women with a large sample population,and summarized the SUVmax of vertebra with no significant difference. The results could provide a quantitative reference for clinical diagnosis and the evaluation of therapeutic response in vertebral lesions.

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Section: Discussioncontrasting

confidence: 77%

“…It has been reported that SUVmax of the vertebra and pelvis was independent of height, however, the results are controversial [29] [30] [11]. The opposite conclusions from these studies may due to the small sample size.…”

Section: Discussionmentioning

confidence: 97%

Establishment of the Standardized Uptake Values of 99mTc-MDP in Normal Vertebrae for SPECT/CT Quantification

Qi¹,

Meng²,

Zhi-wen³

et al. 2020

Preprint

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“…A bone scan is a type of nuclear medicine-based imaging that provides an entire skeletal visualization based on the activity of a radionuclide tracer within a short amount of time. Two of the most widely used bone scan instruments are gamma cameras and single-photon emission computed tomography (SPECT), both of which are used with 99m Tc-methylene diphosphonate (MDP) tracer [ 4 ]. Conventionally, the interpretation of bone scan images has been based on a qualitative approach alone, whereby the images produced are evaluated using relative intensity values rather than absolute tracer concentration values [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, few researchers have studied the measurement of SUV in SPECT/CT bone scans with 99m Tc tracers thus far [ 4 - 6 , 8 , 13 ]. Therefore, the chief purpose of this study is to report the SUV measured for the normal vertebrae of breast cancer patients undergoing 99m Tc-MDP bone scans via a SPECT/CT machine.…”

Section: Introductionmentioning

confidence: 99%

Standardized Uptake Value from Semiquantitative Bone Single-Photon Emission Computed Tomography/Computed Tomography in Normal Thoracic and Lumbar Vertebrae of Breast Cancer Patients

et al. 2020

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This study aims to semiquantitatively evaluate the standardized uptake value (SUV) of 99m Tc-methylene diphosphonate (MDP) radionuclide tracer in the normal vertebrae of breast cancer patients using an integrated single-photon emission computed tomography (SPECT)/computed tomography (CT) scanner. Overview of Literature: Molecular imaging techniques using gamma cameras and stand-alone SPECT have traditionally been utilized to evaluate metastatic bone diseases. However, these methods lack quantitative analysis capabilities, impeding accurate uptake characterization. Methods: A total of 30 randomly selected female breast cancer patients were enrolled in this study. The SUVmean and SUVmax values for 286 normal vertebrae at the thoracic and lumbar levels were calculated based on the patients' body weight (BW), body surface area (BSA), and lean body mass (LBM). Additionally, 106 degenerative joint disease (DJD) lesions of the spine were also characterized, and both their BW SUVmean and SUVmax values were obtained. A receiver operating characteristic (ROC) curve analysis was then performed to determine the cutoff value of SUV for differentiating DJD from normal vertebrae. Results: The mean±standard deviations for the SUVmean and SUVmax in the normal vertebrae displayed a relatively wide variability: BW=3.92±0.27 and 6.51±0.72, BSA=1.05±0.07 and 1.75±0.17, and LBM=2.70±0.19 and 4.50±0.44, respectively. Generally, the SUVmean had a lower coefficient of variation than the SUVmax. For DJD, the mean±standard deviation for the BW SUVmean and SUVmax was 5.26±3.24 and 7.50±4.34, respectively. Based on the ROC curve, no optimal cutoff value was found to differentiate DJD from normal vertebrae. Conclusions: In this study, the SUV of 99m Tc-MDP was successfully determined using SPECT/CT. This research provides an approach that could potentially aid in the clinical quantification of radionuclide uptake in normal vertebrae for the management of breast cancer patients.

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“…SUVs in the normal vertebrae did not show a significant correlation with subject's weight but with the height in a study 25 ; however, another research conveyed the opposite 24 . Regarding differences in SUVs by gender, previous studies also showed different results 25,26 .…”

Section: Discussionmentioning

confidence: 93%

Quantitative SPECT/CT for differentiating between enchondroma and grade I chondrosarcoma

Choi

Han

Chang

et al. 2020

Sci Rep

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Although differentiation between central chondroid tumors is important, their parallelism makes it a diagnostic conundrum for clinicians and radiologists. The objective of this study was to evaluate the efficiency of quantitative single photon emission computed tomography (SPECT)/computed tomography (CT) in differentiating grade I chondrosarcomas from enchondromas. We reviewed SPECT/CT images of patients with enchondromas and grade I chondrosarcomas arising in the long bones. Volume, mean standardized uptake value (SUVmean), and maximum standardized uptake value (SUVmax) of tumors were calculated from SPECT/CT images. In addition, clinical characteristics and radiological information were assessed. Of a total of 34 patients, 14 had chondrosarcomas. Chondrosarcoma group had significantly larger volume, and higher SUVmean and SUVmax of tumors than enchondroma group. There was no significant difference in age and tumor size between two groups. Areas under the receiver-operating characteristic curve (AUCs) for tumor volume, SUVmean, and SUVmax were 0.727, 0.757, and 0.875. In pairwise analyses, SUVmax had larger AUC than SUVmean (p = 0.0216). With a cutoff value of 15.6 for SUVmax, its sensitivity and specificity were 86% and 75% for differentiating between enchondroma and grade I chondrosarcoma. Quantitative SPECT/ CT is a potential method to differentiate grade I chondroarcomas from enchondromas in patients with central chondroid tumors. Differentiation between central chondroid tumors is important because surgical treatment is the only curative management for patients with grade I chondrosarcoma. A wait-and-see policy is permissible for enchondromas in consideration of long-term prognosis 1,2. Nevertheless, their parallelism makes it a diagnostic conundrum for clinicians and radiologists to distinguish them 3. Clinical symptoms such as spontaneous pain are believed to be helpful in distinction. However, patients with enchondroma uncommonly complained of resting pain and the presentation without symptom does not rule out malignancy 4. Although poorly defined margin, deep endosteal scalloping, the size over 5 cm, periosteal reaction without a history of trauma, and epiphyseal location in plain radiography favor chondrosarcoma, the discriminating power of this set of parameters is limited 2,5. While chondrosarcomas with lobulated lesion, osseous destruction and fibrovascular septae on magnetic resonance imaging (MRI), and early enhancement pattern on dynamic contrast-enhanced (DCE) MRI can be used for differential diagnosis of chondroid tumors 6 , their usefulness remains controversial 5,7,8. Interpretation of radiological findings demonstrated low reliability for grading of cartilaginous tumors, even among expert radiologists 3. Diffusionweighted MRI and quantitative assessment by apparent diffusion coefficient values are expected to be attributed to more accurate and consistent diagnosis for that reason. However, the role of diffusion-weighted MRI is also questioned 3,9. Although F-18 fluorodeoxyglucose positron em...

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A retrospective study of SPECT/CT scans using SUV measurement of the normal pelvis with Tc-99m methylene diphosphonate

Cited by 11 publications

References 23 publications

Establishment of the Standardized Uptake Values of 99mTc-MDP in Normal Vertebrae for SPECT/CT Quantification

Establishment of the Standardized Uptake Values of 99mTc-MDP in Normal Vertebrae for SPECT/CT Quantification

Standardized Uptake Value from Semiquantitative Bone Single-Photon Emission Computed Tomography/Computed Tomography in Normal Thoracic and Lumbar Vertebrae of Breast Cancer Patients

Quantitative SPECT/CT for differentiating between enchondroma and grade I chondrosarcoma

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