A retrospective study of regenerative biomaterials used in implant related therapy in the last 15 years in a private dental practice

Doan, Ninh; Reher, Peter; Truong, L.; Duong, Q. T.; Wang, Gui

doi:10.1016/j.ijom.2019.03.160

Cited by 1 publication

(1 citation statement)

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“…33 So, new bone formation is considered to be a prerequisite for the success of dental implant. Most recently, a retrospective study 34 reported that CGF has been widely applied in dental implant via guided bone regeneration. Although the implant success rate was very high after using CGF, it is difficult to compare the results of different literature with high heterogeneity in study design types, CGF preparation protocols, and outcomes measurement.…”

Section: Search Outcomesmentioning

confidence: 99%

Considerations for Clinical Use of Concentrated Growth Factor in Maxillofacial Regenerative Medicine

Chen

Wan

Yang

et al. 2020

Journal of Craniofacial Surgery

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Different strategies have been utilized to facilitate mineralized/soft tissues. Concentrated growth factor (CGF) emerges as a promising biomaterial for regenerative therapy due to high levels of platelets, growth factors, and nucleated cells entrapped in the fibrin scaffold. This review aimed to collect extensive studies on CGF used in maxillofacial regenerative medicine, discussing current obstacles, and expressing some considerations of CGF use. Articles were retrieved systematically without time limitation. In total, 27 human studies were included and separated accordingly. In general, CGF has been most evaluated in implant related therapy and maxillofacial bone regeneration where a majority of articles have revealed favorable outcomes. Little studies have supported the effects on improving probing periodontal depth reductions and clinical attachment level gains for intrabony and furcation defect regeneration. Very little data with high-level evidence was available directly to investigate its effects on the soft tissue regeneration and postoperative complications reduction. The evidence supporting the clinical efficacy of CGF in maxillofacial regenerative medicine is limited. Some conflicting results are worrisome. In addition, the characterization of CGF preparation protocols and CGF's components was not performed in most studies. Further studies should make a consensus on standardized end-product of CGF including characterization of protocols and optimal ratio of CGF' components. Defined algorithms and evidence-based protocols for the clinical use of CGF should be also available.

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Section: Search Outcomesmentioning

confidence: 99%