A Retrospective Study of Nail Squamous Cell Carcinoma at 2 Institutions

Tang, Nikki; Maloney, Mary E.; Clark, Ashlynne H.; Jellinek, Nathaniel J.

doi:10.1097/dss.0000000000000521

Cited by 33 publications

(44 citation statements)

References 43 publications

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“…SCC usually affects a single digit, more often the thumb, the second and the third fingers, but multiple digit involvement may be observed. Nail SCC displays a slow growth and low aggressive behaviour compared to other areas such as the lips and preauricular skin, with a very low rate of metastases reported . However, up to 60% of cases may present bone involvement and the main concern for clinicians are local recurrences.…”

Section: Sccmentioning

confidence: 99%

“…However, up to 60% of cases may present bone involvement and the main concern for clinicians are local recurrences. Similar to BD, SCC of the nail can often be misdiagnosed as viral warts, onychomycosis and other benign lesions . Nail SCC may clinically present as a persistent nail bed hyperkeratosis associated with onycholysis, mimicking a wart, as a nail bed erosion/ulceration or as a nodule with a partial or total destruction of the nail plate (Fig.…”

Section: Sccmentioning

confidence: 99%

“…). The pathogenesis is not fully known but possible causes include chronic radiodermatitis, tobacco use, traumas and HPV infections . The causative role of HPV has been correlated with recurrences after surgical excision .…”

Section: Sccmentioning

confidence: 99%

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Mohs micrographic surgery for nail unit tumours: an update and a critical review of the literature

Lambertini

Piraccini

Fanti

et al. 2018

Acad Dermatol Venereol

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Mohs micrographic surgery (MMS) is a good treatment option for epithelial neoplasms, especially when localized in areas where tissue conservation is crucial, such as the nail unit (NU). MMS is a method of radical excision offering high cure rates due to the margin control and functional preservation. Our aim is to provide a review on the use of MMS for the treatment of the most common nail tumours. We revised the current literature on the use of MMS to treat malignant neoplasms (Bowen's disease, squamous cell carcinoma, melanoma, basal cell carcinoma, keratoacanthoma, carcinoma cuniculatum) and benign neoplasms (onychomatricoma and glomus tumour). MMS represents a successful surgical option for nail tumours, firstly in terms of tissue conservation: the NU anatomy is complex and the preservation of the component structures is imperative for its functionality. Secondly, due to the surgical radicality, which is essential not only for the clearing of malignant tumours, but also for benign cases, in order to reduce recurrences. Although a conservative treatment of NU melanoma with MMS has been proposed, in our experience, the conservative approach with functional surgery is a good option for the treatment of non-invasive melanoma (in situ and Ia).

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Section: Sccmentioning

confidence: 99%

Section: Sccmentioning

confidence: 99%

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Mohs micrographic surgery for nail unit tumours: an update and a critical review of the literature

Lambertini

Piraccini

Fanti

et al. 2018

Acad Dermatol Venereol

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“…Studies have shown strong associations with immunosuppression, current or previous tobacco use, toxin/radiation exposure, and trauma. [1] A number of studies have confirmed a causative role for HPV, mostly HPV16, in the development of this tumor. Bone involvement may occur but metastases are extremely rare.…”

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confidence: 99%

Squamous Cell Carcinoma of the Nail Bed

Mao

Wen

et al. 2017

Chinese Medical Journal

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“…SSCC rarely metastasize, but local recurrences are common [3] . This might be explained by the difficulties of its surgical treatment and to the frequently human papillomavirus-induced pathogeny of the tumor [4,5] .…”

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confidence: 99%

Dermoscopic Features of Subungual Squamous Cell Carcinoma: A Study of 44 Cases

Teysseire

Dalle²,

Duru

et al. 2017

Dermatology

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Background: Subungual squamous cell carcinoma (SSCC) is the most frequent tumor of the nail apparatus. Its diagnosis is often missed or delayed because the clinical presentation is atypical and can mimic other conditions. Accurate diagnosis can only be made by performing an appropriate surgical biopsy, but biopsy is painful and often leaves definitive dystrophic scars. The use of dermoscopy, a noninvasive technique, has been described to be useful for the preoperative evaluation of nail diseases. Objectives: To define the different clinical and dermoscopic presentations of SSCC and to compare them with onychomatricoma-associated clinical and dermoscopic features published in our previous study. Methods: A retrospective review of 44 cases of SSCC seen in our institution over an 8-year period. Six observers scored 19 clinical criteria and 14 dermoscopic criteria as present or absent. Then, we compared those data to a previously published study about the preoperative diagnosis of onychomatricoma. Results: Only 1 dermoscopic criterion was significantly associated with SSCC compared to onychomatricoma: localized hyperkeratosis (odds ratio, OR = 6.25, p = 0.012, 95% confidence interval CI = 1.50-26.01). In contrast, parallel edges (OR = 0.03, p < 0,001, 95% CI = 0.003-0.20) and sharp demarcation of the lesion (OR = 0.24, p = 0.004, 95% CI = 0.09-0.63) can statistically significantly be considered as in favor of onychomatricoma. By contrast, we believe that the presence of unparalleled lateral edges of the nail lesion or of fuzzy edges are more in favor of SSCC. Conclusions: Dermoscopy of the nail plate and of the nail free edge in SSCC provides useful information in order to better select cases to be submitted to biopsy.

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A Retrospective Study of Nail Squamous Cell Carcinoma at 2 Institutions

Abstract: Nail SCC is found nearly exclusively in adults and predominantly in men. There are multiple effective treatment possibilities including Mohs surgery, distal digital amputation, and early evidence suggesting radiotherapy.

Cited by 33 publications

References 43 publications

Mohs micrographic surgery for nail unit tumours: an update and a critical review of the literature

Mohs micrographic surgery for nail unit tumours: an update and a critical review of the literature

Squamous Cell Carcinoma of the Nail Bed

Dermoscopic Features of Subungual Squamous Cell Carcinoma: A Study of 44 Cases

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