A retrospective study of malignant melanoma from a tertiary care centre in Saudi Arabia from 2004 to 2016

Alshedoukhy, Ahlam; Cahusac, Peter; Kashir, Junaid; Alkhawaja, Fatimah H.; Tulbah, Asma; Anwar, Khurshid

doi:10.1007/s12094-019-02169-w

Cited by 3 publications

(4 citation statements)

References 20 publications

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“…Similar to data reported in the literature, the mean age of our patients was 65 years (range: 22-91 years), with a male predominance and an M/F ratio of approximately 1.2 [6,7]. However, Alshedoukhy A et al [8] reported a female predominance and a younger average age in their study. According to data from the literature [9,10], the lower limbs are the most common localization of skin melanoma, which is similar to our findings.…”

Section: Discussionsupporting

confidence: 89%

“…These four subtypes are reported at variable frequencies depending on the series. In our study, as well as in those of Alshedoukhy A et al [ 8 ] and Sharma N et al [ 12 ], the most common histological type diagnosed was NM, followed by ALM. In contrast, Luk NM et al [ 13 ] and Nam KW et al [ 14 ] reported ALM as the most common subtype in their studies, followed by NM, whereas Baykal C et al [ 15 ] found that the most common subtype was SSM, followed by LMM (Table 3 ).…”

Section: Discussionsupporting

confidence: 85%

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Histopathologic and Molecular Features of Cutaneous Melanoma in a Moroccan Population

Tahiri Elousrouti,

Hammas,

Fadlallah

et al. 2023

Cureus

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Background Cutaneous cancer is the most common malignancy type, among which melanomas are considered the most aggressive and lethal. In Morocco, skin melanoma is the 25th most common cancer. To our knowledge, this is the first and largest Moroccan study specifically describing cutaneous melanoma. Materials and methods We obtained data for 100 patients diagnosed with cutaneous melanoma in the Department of Pathology of Hassan II University Hospital, Morocco. Clinical, histopathological, molecular, and follow-up data were recorded from pathology request forms and the patient’s medical records. Results The mean age of our patients was 65 years old. Histologically, the most prevalent were the nodular (48%) and acro-lentiginous (38%) melanoma subtypes. A total of 66% of the patients had a Breslow thickness of >4 mm. The presence of ulceration was noted in 46% of cases. The average mitoses was 9/1 mm². A total of 44% of patients had metastatic melanoma at the time of diagnosis. The BRAF V600E mutation was found in six cases, and the C-KIT mutation in five cases. The five-year overall survival and metastasis-free survival were 85% and 15%, respectively. There was a significant correlation between Breslow thickness and Clark’s level ( p <0.001), histologic subtype ( p =0.012), and presence of metastasis ( p =0.002). There was a significant difference between the head and neck melanomas and those of the feet, particularly in the histological subtype and the presence of ulceration. BRAF V600E mutation was found in six cases of metastatic melanomas of the head and neck, of which three cases were positive for this mutation, as compared with the 23 cases of acral melanomas, which tested negative for the same mutation. Conclusion The results of our study showed that cutaneous melanomas were characterized by advanced age at diagnosis and late-stage diagnosis with a high Breslow index. The lower limbs were the most affected sites, especially in the plantar region. The acral lentiginous subtype was the most common. The presence of BRAF V600E mutation was associated with a better prognosis.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionsupporting

confidence: 85%

Histopathologic and Molecular Features of Cutaneous Melanoma in a Moroccan Population

Tahiri Elousrouti,

Hammas,

Fadlallah

et al. 2023

Cureus

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“…Irritants and carcinogenic elements, such as formaldehyde and tobacco smoke seem to be related to its development and the lack of specific clinical features of nasopharyngeal melanoma often leads to a late diagnosis [19] . A retrospective study from Saudi Arabia revealed that the mucosal melanoma are rare and head and neck melanoma was most seen in mouth rather than tha nasal cavities [20] .…”

Section: Discussionmentioning

confidence: 99%

Nasopharyngeal tumors with unusual presentations: a retrospective analysis from Saudi Arabia

Alzahrani

2024

International Journal of Surgery: Global Health

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The most common malignant lesion in the nasopharynx is the nasopharyngeal carcinoma (NPC), commonly presents with painless upper cervical lymphadenopathy secondary to nodal metastasis and the undifferentiated type is the most common diagnosis. Compared with other types of cancers, NPC is uncommon, albeit with a high difference in geographical distribution where the worldwide cases account for only 0.6% of all annually diagnosed cancers diagnosed, however, in Saudi Arabia the overall incidence among all age groups is 0.1–0.13 per 10 000. Other rare types of malignancies are also seen at the nasopharynx and due to the nonspecific clinical and imaging characteristics; the preoperative diagnosis may be difficult. This study retrospectively assessed the nasopharyngeal tumors diagnosed in a referral hospital in Al-Baha regions, Saudi Arabia during 10 years period that came with unusual presentations at the level of clinical, radiological, or pathological features to raise the awareness of healthcare provides by these entities. Twenty patients were included and revealed unusual (atypical) clinical presentation in 50% of case including a case presented with respiratory symptoms as a first presentation where multiple lung foci were seen and proved to be a metastatic NPC. Histopathological diagnoses were challenging for 40% of the cases revealing unusual malignant types. In summary, however, the nasopharyngeal malignancy is a rare entity, accurate diagnosis may be missed in clinical or even in the pathology examination. Surgeons and pathologists should be aware of the unusual presentation to provide early and more accurate diagnosis for such serous tumors.

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“…The literature shows that regardless of BRAF/NRAS status, small molecule mitochondrial uncoupling agents such as SR4 and niclosamide may become the first-line drugs for the treatment of melanoma and can also be used as adjuvant therapy for patients with failed MAPK inhibitors. In addition, there is also literature indicating that melatonin can serve as one of the drugs to improve the prognosis of melanoma ( 22 ).…”

Section: Discussionmentioning

confidence: 99%

Case report: Malignant melanoma of the lower limb with gastric metastasis

Zhou

Sun

2023

Front. Oncol.

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IntroductionMalignant melanoma with gastric metastasis is extremely rare. We report a case of gastric metastasis caused by malignant melanoma of the lower limb.Case presentationA 60-year-old woman was hospitalized for left plantar pain. The patient found a black maculopapular eruption on the left sole of her left foot, which caused pain when pressed, and the pain was aggravated by walking, so she went to our hospital for treatment. On the second day of admission, the lesion of the left foot was removed under local anesthesia, and the removed tissue was sent for pathological examination. Combined with immunohistochemistry, it was consistent with malignant melanoma. During hospitalization, the patient developed abdominal pain and asked for gastroscopy. Gastroscopy revealed two 0.5 cm × 0.6 cm spots that can be seen arising from the stomach mucosa which were slightly swollen, slightly black in the center, and without erosion, and no abnormality was found in the other parts. At the same time, a biopsy was taken under a gastroscope and pathology suggests malignant melanoma. The patient could not undergo subsequent treatment due to cost. The patient was followed up until February 2022 and was within the survival period.ConclusionMalignant melanoma gastric metastasis is extremely rare. When a patient has a previous history of melanoma surgery, this needs to be considered when gastrointestinal symptoms are present, and regular endoscopic screening is recommended. Early surgical treatment and postoperative chemotherapy or combined targeted therapy may improve the prognosis of patients.

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A retrospective study of malignant melanoma from a tertiary care centre in Saudi Arabia from 2004 to 2016

Cited by 3 publications

References 20 publications

Histopathologic and Molecular Features of Cutaneous Melanoma in a Moroccan Population

Histopathologic and Molecular Features of Cutaneous Melanoma in a Moroccan Population

Nasopharyngeal tumors with unusual presentations: a retrospective analysis from Saudi Arabia

Case report: Malignant melanoma of the lower limb with gastric metastasis

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