A retrospective study of hepatitis B vaccination in preterm birth and low birth weight infants born to hepatitis B surface antigen-positive mothers: Time to close the policy-practice gap

Abstract

National Immunization Program-version 2016 (ISIV-NIP-v2016) recommended a 4-dose hepatitis B vaccine (HepB) schedule for preterm birth (PTB) and low birth weight (LBW) infants born to HBsAg-positive mothers. However, the implementation of this immunization strategy in the past five years has not been fully evaluated in China. We reviewed the data of pregnant women and live-born infants from 24 hospitals between 2016 and 2021 in Lu’an, Anhui province, to estimate the prevalence of PTB, LBW, and hepatitis B virus (HBV) infected pregnant women. We analyzed the vaccination status of HepB and HBIG among PTB and LBW infants born to HBsAg-positive mothers. A total of 160 222 pregnant women and 159 613 live-born infants were included in this study. The estimated prevalence of PTB, LBW and HBV-infected pregnant women was 3.86% (range: 3.28%-5.10%), 2.77% (range: 2.12%-3.66%), and 3.27% (range: 3.03%-3.49%), respectively. We screened 340 PTB and LBW infants born to HBsAg-positive mothers between 2016 and 2020. We found that the coverage of HepB and HBIG among them was 100% and 99.39%. However, the timely vaccination rate of the HepB birth dose was only 78.59% and only four children (1.22%) received the 4-dose HepB as recommended by ISIV-NIP-v2016. The 4-dose of HepB for PTB and LBW infants born to HBsAg-positive mothers recommended by ISIV-NIP-v2016 was not fully implemented. A strong public health intervention should be taken to close the policy-practice gap in China in the future.

The influence of demographic and lifestyle factors on blood donation delay among student population: a retrospective study

“…When analysing the reasons for blood donation delays, the study found that the majority of cases were due to temporary postponement reasons, accounting for 97.75% of the total delay. As China’s national immunisation and voluntary blood donation programmes have developed extensively, the likelihood of blood transfusion-related infections such as hepatitis B has decreased significantly among the population, especially among students who have undergone comprehensive immunisation programmes ( 16 , 17 ). In addition, repeated screening during the blood donation process has led to the exclusion of a large number of donors with infectious diseases such as hepatitis B and syphilis ( 18 ), which is one of the reasons for the decreasing proportion of permanent deferrals over the years.…”

Persistence of antibodies 5 years after hepatitis B vaccination in preterm birth children: A retrospective cohort study using real‐world data

“…The enrolment strategy of this study was divided into two stages. In the first stage, we screened eligible PTB children at 24 major delivery hospitals in Lu'an, China, as reported in our previous study 21 . In total, we screened 1077 PTB children born in 2016.…”

Pravovremenost Vakcinacije Prevremeno Rođene Dece

“…Studija Qin i saradnika je pokazala da je stopa pravovremene vakcinacije protiv hepatitisa B za prevremeno rođenu decu i novorođenčad sa malom porođajnom težinom u 24 bolnice u provinciji Anhui u Kini, od 2016. do 2021.g. bila samo 78,59% (17). Rezultati istraživanja Jacobson i saradnika pokazuju da više od 50% prevremeno rođene dece u državi Washington, SAD, još uvek nije dovoljno vakcinisano u uzrastu od 19 meseci, a jedna trećina prevremeno rođene dece još uvek nije primila vakcinu nakon 36 meseci (18).…”