A Retrospective Study of Canine Pancytopenia

Weiss, Douglas J.; Evanson, Oral A.; Sykes, Jane E.

doi:10.1111/j.1939-165x.1999.tb01053.x

Cited by 36 publications

(58 citation statements)

References 22 publications

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“…A study in the United States evaluated 4560 animals where 2.4% were pancyitopenics (WEISS et al, 1999). Another study in the same teaching hospital identified the non-endemic character for some diseases in the region, scoring as a possible factor that could explain their smaller found prevalence (WEISS, 2006).…”

Section: Discussionmentioning

confidence: 99%

“…The pathogenesis is unclear, but by the response to immunosuppressive therapy presented, there is an evidence of immunemediated mechanism (WEISS, 2003;WEISS et al, 1999;BRAZZELL;WEISS, 2006). In the event of pancytopenia, it can be deduced a chronic aplasia, since the half-life of erythrocytes is long, the last citopenia to occur.…”

Section: Discussionmentioning

confidence: 99%

“…Pancytopenia was defined according to the following values of reference (HCT < 37%; WBC < 6x10 3 /µL and platelets < 200x10 3 /µl) (JAIN, 1993) from automated CBC (Sysmex PocH -Diff 100iV ® Veterinary Hematology Analyzer, Sysmex, Latin America 1659) and cytopenias have been classified according to severity (WEISS et al, 1999).…”

Section: Methodsmentioning

confidence: 99%

“…Prevalence of 1.85% to 2.4% are reported in studies conducted in the United States (WEISS et al, 1999;BRAZZELL;WEISS, 2006). In Brazil there is no recorded data in the occurrence of pancytopenia in dogs.…”

Section: Introductionmentioning

confidence: 99%

“…This hematologic condition may be related to peripheral destruction of the blood cells (WEISS et al, 1999).…”

Section: Introductionmentioning

confidence: 99%

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Quantitative analysis of bone marrow in pancytopenic dogs

Girardi

Campos

Pescador

et al. 2017

SCA

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The pancytopenia can be associated with intra and extra medullary disorders. When the etiology is not obvious, the examination of bone marrow is necessary. The study aims to report and discuss quantitative amendments in bone marrow and their causes in dogs with pancytopenia. Bone marrow aspirate was obtained from 65 dogs with pancytopenia over a period of 13 consecutive months for preparation of smears stained by Giemsa and observed in light microscopy. Five hundred cells differential count was held; and assessed myeloid:erythroid ratio, cellularity, megakaryocytes and direct parasitological examination. The data were evaluated by the Chi-square statistical test. Blood tests of 3120 canines with several clinical changes were analyzed to identify pancytopenia, which accounted for 167 (5.4%) dogs. Interpretation of quantitative characteristics was carried out from the bone marrow smear in 65 pancytopenic dogs and the etiology was established in 40 (61.5%) of these, which included infection by E. canis and L. chagasi, idiopathic aplastic anemia, chronic renal failure and co-infections. In 17 (26.2%) animals were not observed medullary changes. The most bone marrow change was observed myeloid and erythroid hypoplasia in 17 (26.2%) dogs, followed by myeloid and erythroid hyperplasia (24.6%). The myelogram association to the blood cell count allowed the identification of medullary findings and its participation on the occurrence of pancytopenia cases. The number of cases resulting from infectious diseases was 38 (58.5%) in canine assessed: significant number due to its endemic characteristic of the study region. Key words: Cytology. Canine. Cytopenia. Hemoparasites. Myelogram. ResumoA pancitopenia pode estar associada a distúrbios intra e extra medulares. Quando a etiologia não é óbvia, o exame da medula óssea é necessário. Este estudo tem como objetivo relatar e discutir alterações quantitativas na medula óssea e suas causas em cães com pancitopenia. De 65 cães pancitopêncicos atendidos durante um período de 13 meses consecutivos, foram realizados aspirados de medula óssea, corados com Giemsa, e observados em microscopia de luz. Quinhentas células foram observadas para contagem diferencial, razão mieloide: eritróide, celularidade, megacariócitos e exame parasitológico direto. Os dados foram avaliados pelo teste estatístico Qui-quadrado. Hemograma de 3120 caninos com diversas alterações clínicas foram analisadas para identificar a pancitopenia, encontrada em 167 (5,4%) cães. A interpretação das características quantitativas foi realizada a partir do esfregaço de medula óssea em 65 cães pancitotopênicos e a etiologia foi estabelecida em 40 (61,5%), incluindo infecção por

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…This hematologic condition may be related to peripheral destruction of the blood cells (WEISS et al, 1999).…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Quantitative analysis of bone marrow in pancytopenic dogs

Girardi

Campos

Pescador

et al. 2017

SCA

View full text Add to dashboard Cite

show abstract

Leukocytosis and Leukopenia

Burton

Jandrey

2018

Textbook of Small Animal Emergency Medicine

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Aplastic anaemia treated using eltrombopag in a dog

Rodriguez‐Cobos,

Atencia

2023

Vet Record Case Reports

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A 2‐year‐old, neutered, female beagle was presented to a referral hospital for investigation of pancytopenia. The patient had a history of recurrent infections and, on previous blood tests, anaemia, leukopenia and thrombocytopenia were detected. At the time of presentation, the patient had been treated for 2 weeks with omeprazole, amoxicillin‐clavulanic acid, marbofloxacin and gabapentin, and for 3 months with prednisolone, in decreasing doses. A bone marrow aspirate and core biopsy were performed. Hypoplastic bone marrow was observed. Once underlying infectious diseases and exposure to toxins were ruled out, a diagnosis of aplastic anaemia was made. The patient was treated with eltrombopag, a thrombopoietin receptor agonist that stimulates primitive haematopoietic stem cells, used for the treatment of aplastic anaemia in humans. One week after starting eltrombopag treatment, all the affected cellular lines were recovered. The patient continued in remission 7 months after treatment.

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A Retrospective Study of Canine Pancytopenia

Cited by 36 publications

References 22 publications

Quantitative analysis of bone marrow in pancytopenic dogs

Quantitative analysis of bone marrow in pancytopenic dogs

Leukocytosis and Leukopenia

Aplastic anaemia treated using eltrombopag in a dog

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