A retrospective study of 220 cases of keratocystic odontogenic tumor (KCOT) in 181 patients

Yang, Sung-Il; Park, Young-In; Choi, Sie−Young; Kim, Jin-Wook; Kim, Chin-Soo

doi:10.1016/j.ajoms.2011.03.002

Cited by 11 publications

(10 citation statements)

References 36 publications

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“…Chow [12], Brannon [13] and Browne [3] found a mean age of 32.1 -37.8 years at time of diagnosis. The age distribution appears to be bimodal [9]. The sex distribution may be equal, or may be a male predominance (1.3 -3.1) [9].…”

Section: Discussionmentioning

confidence: 94%

“…The age distribution appears to be bimodal [9]. The sex distribution may be equal, or may be a male predominance (1.3 -3.1) [9].…”

Section: Discussionmentioning

confidence: 94%

“…. Several authors have also noted a second peak between the fifth and eighth decades [9]. Chow [12], Brannon [13] and Browne [3] found a mean age of 32.1 -37.8 years at time of diagnosis.…”

Section: Discussionmentioning

confidence: 98%

“…The diagnostic metamorphosis of OKC into a recognized cystic neoplasm occurred after observation of its biological behaviors and modern investigations of chromosomal and genetic abnormalities consistent with neoplastic progression [6] [7]. In 2005 [8], the WHO Working Group considered odontogenic keratocyst (OKC) to be a tumor, recommended the term keratocystic odontogenic tumor (KCOT), separating the lesion from the orthokeratinizing variant, which was now considered an odontogenic cyst [9].…”

Section: Introductionmentioning

confidence: 99%

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Odontogenic Keratocyst Tumor: A Case Report and Literature Review

Belmehdi¹,

Chbicheb²,

Wady³

2016

OJST

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First described by Philipsen in 1956, the odontogenic keratocyst is characterized by a large squamous keratinization of its border, an aggressive growth and a high recurrent rate. It is now designated by the World Health Organization as a keratocystic odontogenic tumour (KOT). Clinically, the KOT is manifested by an asymptomatic growth. Radiographically, it appears as a well-defined unilocular or multilocular osteolytic lesion. The diagnostic approach is based on a combined analysis of the medical history, the clinical appearance and the radiographic appearance. The diagnosis may be confirmed by the anatomical pathology report. Finally, treatment consists of surgical excision and follow up is characterized by a high rate of recurrence. The authors report a case of keratocystic odontogenic tumor of the upper jaw and review the various diagnoses, therapeutics and follow up aspects of this type of tumors.

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Section: Discussionmentioning

confidence: 94%

“…The age distribution appears to be bimodal [9]. The sex distribution may be equal, or may be a male predominance (1.3 -3.1) [9].…”

Section: Discussionmentioning

confidence: 94%

“…. Several authors have also noted a second peak between the fifth and eighth decades [9]. Chow [12], Brannon [13] and Browne [3] found a mean age of 32.1 -37.8 years at time of diagnosis.…”

Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Odontogenic Keratocyst Tumor: A Case Report and Literature Review

Belmehdi¹,

Chbicheb²,

Wady³

2016

OJST

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“…Out of the 756 articles displayed, 153 were pre‐selected based on the title and abstract. To avoid data analysis bias, articles with reference in the title and/or abstract to extraosseous or solid variants of these cysts, along with cases associated with the Gorlin–Goltz syndrome, were not considered.…”

Section: Methodsmentioning

confidence: 99%

Treatment options for keratocyst odontogenic tumour (KCOT): a systematic review

2016

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Background: The keratocystic odontogenic tumour (KCOT) is a benign intraosseous odontogenic lesion relatively frequent in the oral cavity. It has a locally aggressive behaviour and exhibits a high propensity to recur after treatment. All the singular characteristics of this pathology have originated controversy in the scientific community regarding the most appropriate surgical approaches for the successful treatment of this tumour. Objectives: To analyse the optimal treatment choice for this tumour, ensuring high success rates of treatment, preventing future recurrences and allowing the maintenance of the patient's quality of life. Materials and methods: A search was conducted in Cochrane -1 resultand in PubMed -756 results. The selection of articles was based on abstracts and inclusion and exclusion criteria. Three research studies were considered for the final analysis. Results: One hundred and nineteen lesions were identified (73 males and 46 females). Twenty-nine tumours were found in the maxilla and 91 in the mandible; the applied therapeutic methods were: marsupialization/decompression, marsupialization followed by enucleation and adjunctive therapies (peripheral ostectomy and Carnoy's solution), solely enucleation, enucleation and Carnoy's solution, enucleation followed by peripheral ostectomy and Carnoy's solution and resection. Discussion and conclusions: Treatment by enucleation, in combination with adjunctive measures, is associated with minor recurrence rates when compared with enucleation alone. The small number of KCOT that were treated with en bloc resection did not obtain statistically relevant results. Therefore, more studies with well-established criteria are necessary to enable an adequate analysis of recurrence rates associated with each treatment modality.

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