A Retrospective Review of Dupilumab for Hand Dermatitis

Lee, Nicole; Chipalkatti, Naina; Zancanaro, Pedro; Kachuk, Courtney; Dumont, Nicole; Rosmarin, David

doi:10.1159/000496481

Cited by 21 publications

(19 citation statements)

References 4 publications

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“…72 Oosterhaven et al 73 reported about a patient with a longstanding combination of very severe chronic atopic hand eczema and moderate-to-severe atopic dermatitis who had been treated with several systemic drugs. 74 From the publication, it is unclear if these were only patients with atopic dermatitis, or if also other aetiologies were included. Over 12 weeks, her hand eczema improved from 'very severe' and a hand eczema severity index (HECSI) score of 244 (of 360) to 'almost clear' with a HECSI score of 11.…”

Section: Dupilumabmentioning

confidence: 99%

“…Dupilumab treatment was initiated with a loading dose of 600 mg subcutaneously, followed by 300 mg once every 2 weeks. 74 In an observational prospective study, 47 adult patients with hand eczema and atopic dermatitis were treated with dupilumab at a 600 mg loading dose, followed by 300 mg every 2 weeks. 73 In a retrospective chart review, the outcome of 38 dupilumabtreated patients with hand dermatitis was evaluated.…”

Section: Dupilumabmentioning

confidence: 99%

“…73 In a retrospective chart review, the outcome of 38 dupilumabtreated patients with hand dermatitis was evaluated. 74 From the publication, it is unclear if these were only patients with atopic dermatitis, or if also other aetiologies were included. The authors reported that after treatment with dupilumab, the Investigator's Global Assessment (IGA) of patients with hand dermatitis decreased by 1.54 points from 3.26 to 1.72, with 40.0% achieving an IGA of 0 and 1.…”

Section: Dupilumabmentioning

confidence: 99%

“…The authors reported that after treatment with dupilumab, the Investigator's Global Assessment (IGA) of patients with hand dermatitis decreased by 1.54 points from 3.26 to 1.72, with 40.0% achieving an IGA of 0 and 1. 74 In an observational prospective study, 47 adult patients with hand eczema and atopic dermatitis were treated with dupilumab at a 600 mg loading dose, followed by 300 mg every 2 weeks. 75 Primary outcome was a minimum improvement of 75% on the hand eczema severity index after 16 weeks (HECSI-75).…”

Section: Dupilumabmentioning

confidence: 99%

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Hand eczema: treatment

Elsner

Agner

2019

Acad Dermatol Venereol

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Hand eczema is a highly prevalent, multietiological disease with a wide spectrum of severity and chronicity. The treatment of hand eczema, especially in severe and chronic cases, is a challenge to the dermatologist requiring not only diagnostic and therapeutic, but also excellent patient communication skills. This review discusses the spectrum of therapeutic options for hand eczema, the evidence for their efficacy and safety, and proposes a stepwise approach of intensity of treatment depending on disease severity and chronicity. In the near future, hand eczema patients may benefit from new therapeutic principles such as biologics for the treatment of atopic eczema and topical Janus Kinase inhibitors.

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Section: Dupilumabmentioning

confidence: 99%

Section: Dupilumabmentioning

confidence: 99%

Section: Dupilumabmentioning

confidence: 99%

Section: Dupilumabmentioning

confidence: 99%

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Hand eczema: treatment

Elsner

Agner

2019

Acad Dermatol Venereol

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“…Dupilumab könnte z. B. bei einem generalisierten atopischen Ekzem mit Beteiligung der Hände eingesetzt werden [30,31].…”

Section: Therapieunclassified

Die Dermatologie in der BG Klinik Falkenstein

Gina

2019

Akt Dermatol

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ZusammenfassungDas stationäre Heilverfahren im Rahmen der tertiären Individualprävention wurde für schwere, therapieresistente Berufsdermatosen entwickelt, wenn das ambulante Management nicht ausreichend ist. Das Heilverfahren ist mittlerweile gut etabliert und wird in 5 Kliniken deutschlandweit angeboten. Die BG Klinik Falkenstein liegt im Herzen des Vogtlandes umgegeben von einem Naturschutzgebiet. Hier können durch Schulungen, multidisziplinäre Diagnostik und Behandlung sowie Optimierung der Präventionsmaßnahmen eine Steigerung der Motivation und bei ca. ⅔ der Betroffenen ein weiterer Berufsverbleib ermöglicht werden.

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Behandlung nach Stufenschema

Elsner¹,

Schliemann²

2023

Dtsch Dermatolog

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A Retrospective Review of Dupilumab for Hand Dermatitis

Cited by 21 publications

References 4 publications

Hand eczema: treatment

Hand eczema: treatment

Die Dermatologie in der BG Klinik Falkenstein

Behandlung nach Stufenschema

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