A retrospective review of breast reconstruction outcomes comparing AlloDerm and DermaCELL

Greig, Heather; Roller, Janine M.; Ziaziaris, William; Laeken, Nancy Van

doi:10.1016/j.jpra.2019.07.005

Cited by 13 publications

(22 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It should be noted that our results (drain duration and incidence of minor and major postoperative complications) are either similar or lower than reported in previously published studies. The majority of these studies are retrospective [ 37 , 38 , 39 , 40 , 41 ], although three of these studies did have direct comparisons of Alloderm-RTU and Dermacell [ 37 , 38 , 39 , 40 ]. Zenn et al performed a retrospective study of 140 breasts including both immediate and delayed reconstruction and showed no statistically significant difference between Alloderm-RTU and DermACELL in infections (0.8% vs. 1.7% respectively, p = 0.75) or revisional surgery (5.4% vs. 4.2% respectively, p = 0.57) [ 37 ].…”

Section: Discussionmentioning

confidence: 99%

A Randomized Controlled Trial Comparing Alloderm-RTU with DermACELL in Immediate Subpectoral Implant-Based Breast Reconstruction

et al. 2020

View full text Add to dashboard Cite

Background: The effectiveness of different acellular dermal matrices (ADM) used for implant-based reconstruction immediately following mastectomy is an important clinical question. A prospective randomized clinical trial was performed to evaluate the superiority of DermACELL over Alloderm-RTU in reducing drain duration. Methods: Patients undergoing mastectomy with subpectoral immediate and permanent implant-based breast reconstruction were randomized to Alloderm-RTU or DermACELL. The primary outcome was seroma formation, measured by the duration of postoperative drain placement. Secondary outcomes included: post drain removal seroma aspiration, infection, redbreast syndrome, wound dehiscence, loss of the implant, and unplanned return to the operating room. Results: 62 patients were randomized for 81 mastectomies (41 Alloderm-RTU, 40 DermACELL). Baseline characteristics were similar. There was no statistically significant difference in mean drain duration (p = 0.16), with a trend towards longer duration in the Alloderm-RTU group (1.6 days; 95%CI, 0.7 to 3.9). The overall rate of minor and major complications were statistically similar between the two groups; although patients with Alloderm-RTU had 3 times as many infections requiring antibiotics (7.9% vs. 2.5%) with a risk difference of 5.4 (95%CI −4.5 to 15.2), and twice as many unplanned returns to the operating room (15.8% vs. 7.5%) with a risk difference of 8.3 (95% CI −5.9 to 22.5) as DermACELL. Conclusion: This is the first prospective randomized clinical trial comparing the two most commonly used human-derived ADMs. There was no statistically significant difference in drain duration, minor, or major complications between DermACELL over Alloderm-RTU in immediate subpectoral permanent implant-based breast reconstruction post-mastectomy.

show abstract

Section: Discussionmentioning

confidence: 99%

A Randomized Controlled Trial Comparing Alloderm-RTU with DermACELL in Immediate Subpectoral Implant-Based Breast Reconstruction

et al. 2020

View full text Add to dashboard Cite

show abstract

“…14 A 2019 retrospective chart review also found no significant differences in complication rates of seroma, hematoma, mastectomy flap necrosis, or infection between AlloDerm and DermACELL grafts for immediate alloplastic breast reconstruction. 26 Acellular skin substitutes are products derived from human placental membrane, also known as human amnion chorion membrane (HACM) allografts. Those products that are commercially available include EpiFix (MiMedx Group Inc., Marietta, GA) and AmnioRepair (Zimmer Biomet, Warsaw, IN).…”

Section: Acellular Skin Substitutesmentioning

confidence: 99%

Comparison of Skin Substitutes for Acute and Chronic Wound Management

et al. 2021

View full text Add to dashboard Cite

Chronic and acute wounds, such as diabetic foot ulcers and burns, respectively, can be difficult to treat, especially when autologous skin transplantations are unavailable. Skin substitutes can be used as a treatment alternative by providing the structural elements and growth factors necessary for reepithelialization and revascularization from a nonautologous source. As of 2020, there are 76 commercially available skin substitute products; this article provides a review of the relevant literature related to the major categories of skin substitutes available.

show abstract

“…1,2 The recent development of acellular dermal matrixes (ADM) allowed surgeons to attempt an immediate single-stage breast reconstruction, providing better lower pole coverage and inframammary fold definition, improved aesthetic results, and reduced capsular contracture rates. 1,3,4 Despite some of these findings, the data regarding the safety and efficacy of ADM is still conflicting. 5 Complications in breast reconstruction can cause morbidity in several ways but the most important one is the delay of subsequent oncologic treatment.…”

Section: Introductionmentioning

confidence: 99%

Impact of Body Mass Index, Age and Tobacco Use on the Outcomes of Immediate Breast Reconstruction with Implants and Acellular Dermal Matrix

Ribeiro

Meireles

Brito

et al. 2021

Indian J Plast Surg

View full text Add to dashboard Cite

Background This study aimed to analyze the effect of body mass index (BMI), age, and tobacco use on alloplastic breast reconstruction. Methods We conducted a retrospective study of patients who submitted to immediate breast reconstructions with an anatomical implant and acellular dermal matrix in a single center between 2016 and 2018. Outcomes evaluated included immediate complications, early complications, reinterventions, readmissions, and reconstruction failure. Patients were divided into two groups concerning each potential risk factor (BMI < or ≥25; age < or ≥ 50 years; and smokers vs nonsmokers). Simple descriptive statistics and univariate analysis were performed. Results A total of 101 breast reconstructions (73 patients) were included in the analysis. The mean BMI was 24, and the mean age was 44.5 years old. Smokers accounted for 14 breast reconstructions (13.9%). The rate of early infections, mastectomy flap necrosis, and implant removal was significantly higher in overweight patients. The total volume of breast drainage was higher in the age ≥ 50 years group. Smoking did not alter the outcomes. Conclusions A BMI ≥ 25 is a risk factor for early infections and reconstructive failure. Age ≥ 50 years is associated with a higher volume of breast drainage but does not seem to impact the success of the reconstruction. Smoking does not appear to affect the outcomes significantly in this type of reconstruction. Surgeons should consider delaying the reconstruction or using autologous tissue when patients are overweight.

show abstract

A retrospective review of breast reconstruction outcomes comparing AlloDerm and DermaCELL

Cited by 13 publications

References 31 publications

A Randomized Controlled Trial Comparing Alloderm-RTU with DermACELL in Immediate Subpectoral Implant-Based Breast Reconstruction

A Randomized Controlled Trial Comparing Alloderm-RTU with DermACELL in Immediate Subpectoral Implant-Based Breast Reconstruction

Comparison of Skin Substitutes for Acute and Chronic Wound Management

Impact of Body Mass Index, Age and Tobacco Use on the Outcomes of Immediate Breast Reconstruction with Implants and Acellular Dermal Matrix

Contact Info

Product

Resources

About