A Retrospective Propensity Score Matched Study of the Preoperative C-Reactive Protein to Albumin Ratio and Prognosis in Patients with Resectable Non-Metastatic Breast Cancer

Zhou, Lin; Ma, Shihui; Balde, Alpha Ibrahima; Han, Shuai; Cai, Zhai; Zhou, Li

doi:10.12659/msm.913684

Cited by 20 publications

(25 citation statements)

References 30 publications

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Section: Discussionmentioning

confidence: 99%

“…One study by Zhou L showed that 200 patients with non-metastatic breast cancer receiving modified radical mastectomy used the CAR to predict the prognosis, and CAR was significantly associated with reduced DFS and OS, and proved that an increased CRP to albumin ratio was an independent risk factor for long-term outcome and predicted reduced DFS and OS. 31 Yubo Liu's study found that patients with high CRP/ Alb had poor overall survival compared to those with low CRP/Alb, and CRP/Alb was an independent prognostic factor for overall survival. 32 Endocrine therapy represents an important strategy in the management of hormone positive breast cancer.…”

Section: Dovepressmentioning

confidence: 99%

See 1 more Smart Citation

Preoperative Serum Hypersensitive-c-Reactive-Protein (Hs-CRP) to Albumin Ratio Predicts Survival in Patients with Luminal B Subtype Breast Cancer

Liu¹,

Guo²,

Zhang³

2021

OTT

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To evaluate the clinical prognostic significance of preoperative serum hypersensitive-c-reactive-protein (Hs-CRP) to albumin ratio (CAR) in patients with luminal B subtype breast cancer. Methods: A total of 199 patients with luminal B subtype breast cancer enrolled in this study were analyzed retrospectively. The optimal cutoff value of CAR was performed by the receiver operating characteristic curve (ROC). The associations between luminal B subtype breast cancer and clinicopathological variables by CAR were performed by chi-square test. Kaplan-Meier and log rank method were used for survival analysis. The independent prognostic factors were determined by univariate and multivariate Cox's proportional hazards regression model. Results: The patients were divided into low CAR group (CAR<0.044) and high CAR group (CAR≥0.044) by ROC. CAR was the independent factor by univariate and multivariate analysis, and the mean DFS and OS in the low CAR group survived longer than those in the high CAR group (p<0.05). According to the endocrine therapy with aromatase inhibitors, the mean survival time of DFS and OS in the low CAR group was significantly higher than that in the high CAR group (p<0.05). Moreover, patients with pathological I+II stage survived longer than those with pathological III stage, and the mean survival time of DFS and OS in the low CAR group was significantly higher than that in the high CAR group (p<0.05). Patients without lymph vessel invasion survived longer than those with lymph vessel invasion (p<0.05), and the mean survival time of DFS and OS in low the CAR group was significantly higher than that in the high CAR group (p<0.05). Conclusion:Preoperative CAR was significantly associated with survival and prognosis of breast cancer, and it can be used as a routine prognostic indicator to predict the prognosis of luminal B subtype breast cancer.

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Section: Discussionmentioning

confidence: 99%

Section: Dovepressmentioning

confidence: 99%

Preoperative Serum Hypersensitive-c-Reactive-Protein (Hs-CRP) to Albumin Ratio Predicts Survival in Patients with Luminal B Subtype Breast Cancer

Liu¹,

Guo²,

Zhang³

2021

OTT

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“…CAR was initially assessed in patients with acute diseases and sepsis. 81 , 82 Recently, its prognostic value has gained importance in cancers including hepatocellular carcinoma, 83 gastric cancer, 84 and esophageal squamous cell carcinoma, 85 as well as ovarian, 86 breast, 87 and cervical cancers. 87 Elevated preoperative CAR levels are thought to be associated with poor survival of patients with these tumor types.…”

Section: Inflammatory Markersmentioning

confidence: 99%

“… 81 , 82 Recently, its prognostic value has gained importance in cancers including hepatocellular carcinoma, 83 gastric cancer, 84 and esophageal squamous cell carcinoma, 85 as well as ovarian, 86 breast, 87 and cervical cancers. 87 Elevated preoperative CAR levels are thought to be associated with poor survival of patients with these tumor types. Moreover, the CAR index may serve as a prognostic biomarker of cardiotoxicity during anti-cancer therapy.…”

Section: Inflammatory Markersmentioning

confidence: 99%

Role of Systemic Inflammatory Reaction in Female Genital Organ Malignancies – State of the Art

Mleko¹,

Pityński²,

Pluta³

et al. 2021

CMAR

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Systemic inflammatory reaction (SIR) is an unfavorable prognostic factor in many malignancies and has a role in all stages of the neoplastic process: initiation, promotion, and disease progression. Analysis of SIR can be performed by assessing indicators (eg, lymphocyte-to-neutrophil, platelet-to-lymphocyte, and monocyte-to-neutrophil ratios) and products of neutrophils and lymphocytes (ie, the systemic immune-inflammation index), or by examining the relationship between levels of C-reactive protein and albumin (based on the Glasgow Prognostic Score, modified Glasgow Prognostic Score, and C-reactive proteinto-albumin ratio). Risk stratification is essential in the clinical management of cancer; hence, the evaluation of these factors has potential applications in the clinical management of patients with cancer and in the development of new therapeutic targets. This review summarizes the current knowledge on SIR indicators and presents their clinical utility in malignancies of the female genital organs.

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“…In addition, the prognostic value of CRP kinetics, dynamic change of CRP level throughout treatment, has been con rmed in metastatic nasopharyngeal carcinoma and renal cell carcinoma [27][28][29]. Furthermore, a novel prognostic markers involving in ammation and nutrition, CRP to albumin ratio (CAR), has been evaluated in colorectal cancer, liver cell carcinoma, lung cancer, and other solid tumors [30][31][32][33][34]. The prognostic signi cance of CRP level, CRP kinetics and CAR in B-iNHL are unclear.…”

Section: Introductionmentioning

confidence: 99%

The Value of C-Reactive Protein, C-Reactive Protein Kinetics and C-reactive Protein to Albumin Ratio on Prognosis in Newly Diagnosed Indolent B-cell Non-Hodgkin Lymphoma

Zhang¹,

Zhou²,

Sun³

et al. 2020

Preprint

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Objective: This study aimed to determine prognostic significance of C-reactive protein (CRP), CRP kinetics and CRP to albumin ratio (CAR) in indolent B-cell non-Hodgkin lymphoma (B-iNHL) patients. Methods: The association among these blood makers and overall survival (OS), disease-free survival (DFS), progression-free survival (PFS) were analyzed in 243 B-iNHL patients. OS, DFS and PFS were determined by Kaplan–Meier curves. Cox proportional analysis was performed to examine the prognostic significance of clinicopathological variables. Results: Multivariate analyses identified that elevated pretreatment CRP (HR: 5.110, 95% CI: 1.904-13.717, p=0.001), post-treatment CRP (HR: 5.826, 95% CI: 1.659-20.458, p=0.006), continuously elevated CRP (HR: 6.461, 95% CI: 2.620-15.930, p<0.001) and elevated CAR (HR: 3.768, 95% CI: 1.415-10.034, p=0.008) had association with worse OS. Likewise, elevated pretreatment CRP (HR: 3.767, 95% CI: 1.777-7.984, p=0.001), post-treatment CRP (HR: 2.384, 95% CI: 1.027-5.534, p=0.043), ever-elevated CRP (HR: 2.425, 95% CI: 1.105-5.322, p=0.027), continuously elevated CRP (HR: 4.748, 95% CI: 2.114-10.660, p<0.001) and elevated CAR (HR: 2.824, 95% CI: 1.336-5.971, p=0.007) were in independent significance with worse DFS. Elevated pretreatment CRP (HR: 2.606, 95% CI: 1.338-5.076, p=0.005), ever-elevated CRP (HR: 2.086, 95% CI: 1.040-4.188, p=0.039), continuously elevated CRP (HR: 3.296, 95% CI: 1.594-6.818, p=0.001) and elevated CAR (HR: 1.991, 95% CI: 1.021-3.882, p=0.043) were determined in independent significance with poor PFS. The effect was statistically significant in both follicular lymphoma (FL) and chronic lymphocytic leukemia/ small lymphocytic lymphoma (CLL/ SLL) patients.Conclusions: In conclusion, we demonstrate that CRP level, CRP kinetics and CAR could be potential prognostic indicators with independent significance in patients with B-iNHL, also in FL and CLL/ SLL subgroups. CRP and CAR make an implementation for prognostic evaluation more easily and effectively in B-iNHL patients.

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A Retrospective Propensity Score Matched Study of the Preoperative C-Reactive Protein to Albumin Ratio and Prognosis in Patients with Resectable Non-Metastatic Breast Cancer

Cited by 20 publications

References 30 publications

Preoperative Serum Hypersensitive-c-Reactive-Protein (Hs-CRP) to Albumin Ratio Predicts Survival in Patients with Luminal B Subtype Breast Cancer

Preoperative Serum Hypersensitive-c-Reactive-Protein (Hs-CRP) to Albumin Ratio Predicts Survival in Patients with Luminal B Subtype Breast Cancer

Role of Systemic Inflammatory Reaction in Female Genital Organ Malignancies – State of the Art

The Value of C-Reactive Protein, C-Reactive Protein Kinetics and C-reactive Protein to Albumin Ratio on Prognosis in Newly Diagnosed Indolent B-cell Non-Hodgkin Lymphoma

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