A retrospective on topical retinoids occasioned by observation of unexpected interactions of retinoic acid with androgens and glucocorticoids in immortalized lacrimal acinar cells

Alteration of Gene Expression in Pathological Keratinization of the Ocular Surface

“…However, even with topical treatment, side effects such as meibomian gland inflammation and keratitis have been reported, and it has not yet reached any practical use in the clinical setting. 29 – 31 Recently, a report regarding the safety and efficacy of retinol palmitate ophthalmic solution for SJS with OS keratinization is of great interest. 29 We consider it necessary to use more specific ligands such as RARB as therapeutic agents and to find new therapeutic targets by clarifying the causes of decreased expression of only RARB.…”