A Retrospective Multicentric Study of Electrochemotherapy in the Treatment of Feline Nasal Planum Squamous Cell Carcinoma

Simčič, Petra; Pierini, Alessio; Lubas, George; Lowe, Ron; Granziera, Valentina; Tornago, Raimondo; Valentini, Fabio; Alterio, Giulia; Cochi, Matteo; Rangel, Marcelo Monte Mór; Oliveira, Krishna Düro de; Freytag, Jennifer; Quadros, Priscila Gil; Sponza, E; Gattino, Francesca; Impellizeri, Joseph A.; Torrigiani, Filippo

doi:10.3390/vetsci8030053

Cited by 13 publications

(29 citation statements)

References 47 publications

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“…We reserve RT for very large tumors when the risk of relapse with a single ECT session is high. Very large tumors can be challenging to treat with ECT, as areas may be left untreated unintentionally [40] . If large tumors are meant to be treated with ECT, a close follow-up is advisable.…”

Section: Discussionmentioning

confidence: 99%

“…ECT may be used independently or in combination with surgery, especially when the surgery cannot provide clean margins. ECT may be used as a neoadjuvant, adjuvant, or concomitant therapy [37][38][39][40] . Some authors have reported an objective response rate of 97.3% when treating feline patients with nasal planum cSCC with minimum side effects [41] .…”

Section: Electrochemotherapymentioning

confidence: 99%

“…Some authors have reported an objective response rate of 97.3% when treating feline patients with nasal planum cSCC with minimum side effects [41] . ECT may also be used in combination with chemotherapy, RT, or cryosurgery for selected cases [40] . In the Discussion Section, we present our recommendations for performing ECT alone or combined with other therapies for treating cSCC in cats.…”

Section: Electrochemotherapymentioning

confidence: 99%

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Electrochemotherapy using thin-needle electrode improves recovery in feline nasal planum squamous cell carcinoma - a translational model

Tellado¹,

Michinski²,

Impellizeri³

et al. 2022

Cancer Drug Resist

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Aim: Cutaneous squamous cell carcinoma (cSCC) is a common disease in patients exposed to UV-light and human papillomavirus. Electrochemotherapy, a well-established treatment modality with minimum side effects in human and veterinary medicine, circumvents chemoresistance to bleomycin by the use of electric fields. However, patients are sensitive to the trauma produced by the insertion of the needles that lengthen recovery times, particularly cats with nasal planum cSCC. To address this matter, we developed thin-needles electrodes. Methods: Thin-needles electrodes developed using computer simulations and plant tissue models were compared to standard electrodes. A prospective non-randomized study recruiting 52 feline patients with nasal planum cSCC was performed. Local response, anorexia, and overall survival were evaluated. Results: Computer simulations and plant model experiments showed satisfactory results with both electrodes. The patients treated with the thin-needle electrode obtained similar local response rates compared to the standard group, OR 97.3% vs. 80%, respectively (P < 0.067). Most patients in the thin-needle group resumed eating in less than 48 h, as the anorexia was significantly lower (P < 0.0001). Using the standard electrode, most patients took 3 to 5 days to resume normal feeding. The electric current circulating in the standard electrode was 44% higher, contributing to a longer duration of anorexia due to tissue damage. The overall survival in both groups was similar. Conclusion: Electrochemotherapy using thin-needle electrodes provides equivalent local response rates and overall survival compared with standard electrodes but significantly reduced return to appetite after the treatment. These results may be useful in the development of new electrodes for human patients.

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Section: Discussionmentioning

confidence: 99%

Section: Electrochemotherapymentioning

confidence: 99%

Section: Electrochemotherapymentioning

confidence: 99%

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Electrochemotherapy using thin-needle electrode improves recovery in feline nasal planum squamous cell carcinoma - a translational model

Tellado¹,

Michinski²,

Impellizeri³

et al. 2022

Cancer Drug Resist

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“… 6 ECT has also been shown to have good safety and efficacy in treating feline squamous cell carcinoma of the nasal planum. 17 …”

Section: Discussionmentioning

confidence: 99%

“…6 ECT has also been shown to have good safety and efficacy in treating feline squamous cell carcinoma of the nasal planum. 17 There is currently minimal literature describing ECT treatment for feline nasal melanoma. One case report describes the use of ECT combined with calcium electroporation (CaEP) for the treatment of a cat with cutaneous malignant melanoma with regional metastasis; the affected animal had a cutaneous peripalpebral plaque lesion, with submandibular lymph node enlargement.…”

Section: Discussionmentioning

confidence: 99%

Electrochemotherapy as a treatment option for feline nasal melanoma

Little

Macfarlane

2022

Journal of Feline Medicine and Surgery Open Reports

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Case summary A 4-year-old domestic shorthair cat presented to North Downs Specialist Referrals for treatment of a 7 mm melanoma of the nasal planum. Two treatments of electrochemotherapy using intravenous bleomycin as a chemotherapeutic agent were administered. The tumour was no longer visible after treatment. At the 292-day follow-up there was no recurrence at the site and the patient was clinically well. Relevance and novel information There are few data concerning the outcomes of cats with non-ocular feline melanomas and there are currently minimal descriptions in the literature of electrochemotherapy as a treatment option. The available data suggest that nasal melanoma may have a worse prognosis, and that melanomas are locally invasive and have a high propensity for metastasis. The current most effective means for local control is surgery with wide margins. Given the location in this case, this would have required nasal planectomy, while electrochemotherapy provided an effective and possibly more attractive alternative.

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Evaluation of the safety and feasibility of electrochemotherapy with intravenous bleomycin as local treatment of bladder cancer in dogs

Rangel,

Linhares,

de Oliveira

et al. 2023

Sci Rep

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Local treatment of canine urothelial carcinoma (UC) of the bladder is a challenge. More than 90% of the cases invade the muscular layer, more than 50% develop on bladder sites with a difficult surgical approach and often requiring radical surgical procedures. This study aims to evaluate the safety and feasibility of electrochemotherapy (ECT) with intravenous bleomycin (BLM) as a local therapy for bladder UC. This prospective study included 21 dogs with spontaneous bladder UC. Regional/distant metastases and neoplastic infiltration of the serosa was considered the main exclusion criteria. We had no deaths during ECT or in the immediate postoperative period, and no suture dehiscence. Most dogs (19/21) developed mild adverse effects, whereas two dogs developed ureteral stenosis. Complete response (CR) was achieved in 62% of the cases (13/21), while partial response (PR) was achieved in 24% (5/21). The median survival and disease-free survival times were 284 and 270 days, respectively. Overall survival was significantly better in the dogs who achieved a CR. In conclusion, ECT was well-tolerated in dogs with UC, demonstrating its safety and feasibility. These data pave the way for new studies aimed at evaluating the effectiveness of ECT in canine bladder UC as a translational model for human disease.

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A Retrospective Multicentric Study of Electrochemotherapy in the Treatment of Feline Nasal Planum Squamous Cell Carcinoma

Cited by 13 publications

References 47 publications

Electrochemotherapy using thin-needle electrode improves recovery in feline nasal planum squamous cell carcinoma - a translational model

Electrochemotherapy using thin-needle electrode improves recovery in feline nasal planum squamous cell carcinoma - a translational model

Electrochemotherapy as a treatment option for feline nasal melanoma

Evaluation of the safety and feasibility of electrochemotherapy with intravenous bleomycin as local treatment of bladder cancer in dogs

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