A retrospective multicentre study of COCKLE, an oral chemotherapy regimen, as palliative treatment for high grade lymphoma

Managing relapsed refractory lymphoma with palliative oral chemotherapy: A multicentre retrospective study

“…However, there remain few published studies reporting the efficacy or tolerability of palliative oral chemotherapy options and the combination regimens used vary from centre to centre. These include DECC (dexamethasone, etoposide, chlorambucil and lomustine) [8], CEP (lomustine, etoposide, prednisolone) [9] and COCKLE (lomustine, cyclophosphamide, etoposide, prednisolone) [10] for patients with relapsed/refractory Hodgkin lymphoma or NHL. PEP-C (prednisolone, etoposide, procarbazine, cyclophosphamide) is a palliative chemotherapy regimen used in the relapsed/refractory setting for both MCL [11] and other lymphoma subtypes [12].…”