A retrospective multi-centre study of the effects of allogeneic haematopoietic SCT on pulmonary function

Dharmagunawardena, Ruvini; Pearce, Rachel; Thomas, Gavin; Kirkland, Keiren; Perry, Julia; Apperley, Jane F.; Medd, Patrick; Wilson, Keith; Orchard, Kim; Jackson, Graham; Snowden, John A.; Cook, Gordon; Brown, Jeremy

doi:10.1038/bmt.2014.154

Cited by 3 publications

(3 citation statements)

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“…In addition, most studies reviewed long periods characterised by variations in PFT screening strategies and diagnostic criteria for LONIPCs and HSCT procedures. Furthermore, although recommended, adherence to PFT guidelines in HSCT recipients is poor in routine practice and leads to missing data [12].…”

Section: Introductionmentioning

confidence: 99%

“…Even after 2005, some authors used modified criteria to improve their sensitivity [4,14,15]. Recent studies have also shown that regardless of the diagnostic criteria of BOS, a significant proportion of patients experience a significant decline in forced expiratory volume in 1 s (FEV1) after HSCT [12]. Data suggest that this decline could be a good predictor for the development of subsequent BOS.…”

Section: Introductionmentioning

confidence: 99%

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Noninfectious lung complications after allogeneic haematopoietic stem cell transplantation

et al. 2018

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Epidemiological data on late-onset noninfectious pulmonary complications (LONIPCs) following allogeneic haematopoietic stem cell transplantation (HSCT) are derived exclusively from retrospective studies and are conflicting. We aimed to evaluate prospectively the incidence, risk factors and outcomes for LONIPCs.All consecutive patients scheduled to receive allogeneic HSCT between 2006 and 2008 at a university teaching hospital in France were screened for inclusion in the study. Eligible patients were those surviving at day 100. Among 243 screened patients, 198 patients were included in the analysis. The median (interquartile range) follow-up was 72.3 (15.2-88.5) months. 55 LONIPCs were diagnosed in 43 patients. Bronchiolitis obliterans syndrome (n=22) and interstitial lung disease (n=12) were the most common LONIPCs. At 36 months after inclusion, the estimated cumulative incidence of LONIPCs was 19.8% (95% CI 14.2-25.3%). The estimated median survival after the diagnosis of LONIPCs was 78.5 months (95% CI 20.0-not reached). Based on a multivariate Cox model, a history of chest irradiation anytime prior to HSCT, a history of pneumonia within 100 days post-HSCT and a low mean forced expiratory flow at 25-75% of forced vital capacity at day 100 were associated with the development of LONIPCs.Our data provide clues to identify patients at high risk of developing LONIPCs. These patients should be targeted for close monitoring to provide earlier LONIPC treatment or prophylactic treatment.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Noninfectious lung complications after allogeneic haematopoietic stem cell transplantation

et al. 2018

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“…Supporting this is the study by Dharmagunawardena, et al where 46% of their patients with new PFT abnormalities after HSCT had restrictive disease. 91 Typically restriction on PFT's are found early after HSCT, within 100-300 days after transplant, and are frequently transient in nature 14 and Unpublished observations. Only 2.4% percent of patients with findings of restriction on PFT's go on to develop severe restrictive lung disease.…”

Section: Treatment For Bronchiolitis Obliterans Syndromementioning

confidence: 99%

Obstructive and Restrictive Lung Disease After Hematopoietic Stem Cell Transplantation

Arndt

2024

MRAJ

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Pulmonary complications are frequently encountered by clinicians in patients who have undergone hematopoietic stem cell transplantation and are associated with increased morbidity and mortality in these patients. Complications involving the lung are caused by both infectious and non-infectious etiologies, with non- infectious complications associated with significant long-term effect on the quality of life and can occur several years after transplantation. One manifestation of non-infectious post-transplant complication is a change in pulmonary function testing compared to pre-transplant testing. These changes can either be of an obstructive or restrictive pattern with each being associated with specific post-transplant complications. An improved understanding of obstructive and restrictive lung disease after hematopoietic stem cell transplant is necessary for both primary care physicians and specialists to recognize these diseases early in their course in order to facilitate work-up, treatment, and necessary follow-up. This review will provide an overview of obstructive and restrictive lung disease after hematopoietic stem cell transplant focusing on the etiologies, diagnosis, treatment, and outcomes. We will highlight bronchiolitis obliterans syndrome as an example of obstructive disease after transplant and will discuss pleuroparenchymal fibroelastosis as a cause for restrictive findings on pulmonary function testing. Improvements in the knowledge of the underlying etiologies and pathophysiology of obstructive and restrictive lung disease after hematopoietic stem cell transplant will allow for the identification of novel biomarkers to facilitate the diagnosis of these patients and will assist in the design of future targeted therapies to improve treatment and prognosis.

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Impact of the Conditioning Regimen Dose Intensity Before Autologous Stem Cell Transplantation on the Pulmonary Function Test Abnormalities in Patients With Lymphoma and Multiple Myeloma: Single Center Experience

Akl

Matar

Khalil

et al. 2020

Clinical Lymphoma Myeloma and Leukemia

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A retrospective multi-centre study of the effects of allogeneic haematopoietic SCT on pulmonary function

Cited by 3 publications

References 8 publications

Noninfectious lung complications after allogeneic haematopoietic stem cell transplantation

Noninfectious lung complications after allogeneic haematopoietic stem cell transplantation

Obstructive and Restrictive Lung Disease After Hematopoietic Stem Cell Transplantation

Impact of the Conditioning Regimen Dose Intensity Before Autologous Stem Cell Transplantation on the Pulmonary Function Test Abnormalities in Patients With Lymphoma and Multiple Myeloma: Single Center Experience

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