A retrospective institutional study of histopathologic pattern of Oral Squamous Cell Carcinoma (OSCC) in Tehran, Iran during 2006-2015

Abstract

Background: Despite the available data on demographic information of oral squamous cell carcinoma (OSCC), the changing trend of histopathologic pattern of OSCC has not conducted yet, in Iran. The aim was to investigate the pattern of histopathologic features of OSCC in Iran by analyzing the patients referred to Cancer Institute, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran, during 2006-2015. Materials and Methods: The study was a retrospective institutional study. The pathology records with the diagnosis of OSCC were retrieved from Iran National Tumor Bank, Cancer Biology Research Center, Cancer Institute of Iran, Tehran University of Medical Sciences, Tehran, Iran, during 2006-2015. The demographic characteristics and histopathologic features were recorded and analyzed for possible trend. Descriptive analysis was used for statistical interpretation. Results: The data showed an increasing number of moderately and poorly differentiated OSCC. Accordingly, higher increasing rate in tumor size and vascular, perineural invasion was detected. Conclusion: On the basis of histopathologic features, moderately differentiated OSCC with increasing rate of tumor size and vascular, perineural invasion was indicated in recent decade. Based on the findings, lower differentiation potentially is compatible with worsen prognosis.

p53 & Cyclin D1 expression in surgically resected clear margins of oral squamous cell carcinoma

“…Oral cancer is the 8th most frequent cancer among males and the 14th most frequent cancer among females globally 2 . The current findings state the increasing prevalence of oral cancer in Asia, especially in India has been documented 1 .…”

“…Oral cancer makes up to 2% of all the cancer cases with the majority being Oral Squamous Cell Carcinoma (OSCC) which accounts for 90% of all the oral malignancies 1 . Oral cancer is the 8th most frequent cancer among males and the 14th most frequent cancer among females globally 2 .…”

Genes involved in metastasis in oral squamous cell carcinoma: A systematic review

“…In Asia, there have been tendencies toward increasing and decreasing OSCC incidence in Sri Lanka and Pakistan, respectively 9 . The epidemiological pattern of OSCC in Iran is comparable to other cancers and remarkably similar to that of Pakistan and India 10 …”

“…9 The epidemiological pattern of OSCC in Iran is comparable to other cancers and remarkably similar to that of Pakistan and India. 10 Despite the recent progress in chemotherapy, radiotherapy, and traditional surgery, the 5-year survival rate of OSCC still hovers around 50%. 6 It has been proposed that OSCC development is etiologically related to alcohol consumption, tobacco use, Shammah, khat chewing, water pipe smoking, ethnicity, sexual behaviors, human papillomavirus infection, occupational activity, external agent exposure, dietary micronutrient deficiency.…”

Paper-Based Strip for Ultrasensitive Detection of OSCC-Associated Salivary MicroRNA via CRISPR/Cas12a Coupling with IS-Primer Amplification Reaction

“…Oral squamous cell carcinoma (OSCC) is one of the most common malignancies in humans and has significant morbidity and poor prognosis worldwide . However, OSCC was usually diagnosed at late stages because of the rare symptoms, and hence, there was still poor survival of OSCC patients in the past years despite the progress in diagnosis and therapy . Moreover, the therapy for the terminal OSCC may damage the patient’s face, undermining the confidence and causing depression .…”