A Retrospective Evaluation of Hospitalizations for Acute Gastroenteritis at 2 Sentinel Hospitals in Central Japan to Estimate the Health Burden of Rotavirus

Kamiya, Hajime; Nakano, Takashi; Inoue, Masakazu; Kamiya, Hitoshi; Thura, T.; Patel, Manish; Orenstein, Walter A.; Parashar, Umesh D.

doi:10.1086/605028

Cited by 30 publications

(46 citation statements)

References 10 publications

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“…The RESG has conducted a retrospective study (2003)(2004)(2005)(2006)(2007)) and a prospective active surveillance study (2008)(2009)) among inpatients with RV gastroenteritis in Mie Prefecture, Japan. The results of these studies have shown that the disease burden of hospitalization for RV gastroenteritis in Japan is comparable to that of other developed countries (8,9). Our group has continued to conduct studies on RV vaccine efficacy and cost-effectiveness with respect to the introduction of RV vaccines into the national immunization program.…”

Section: Introductionmentioning

confidence: 73%

“…RV genotypes were determined using reverse transcription-polymerase chain reaction. In Tsu City, G3P [8] was dominant (61.0-77.1 ) before vaccine introduction, but decreased after introduction. Meanwhile, in an inverse proportion to the decrease in G3P [8], G1P [8] increased until the 2013 14 season, when a sudden predominance of G2P [4] (100 ) occurred.…”

Section: Discussionmentioning

confidence: 99%

“…In Tsu City, G3P [8] was dominant (61.0-77.1 ) before vaccine introduction, but decreased after introduction. Meanwhile, in an inverse proportion to the decrease in G3P [8], G1P [8] increased until the 2013 14 season, when a sudden predominance of G2P [4] (100 ) occurred. A similar trend was observed in Kurashiki City in terms of the extent of reduction in G3P [8] and the emergence of G2P [4].…”

Section: Discussionmentioning

confidence: 99%

“…In 2009, the World Health Organization recommended that all nations include an RV vaccine in their national immunization programs (1). However, in Japan, the attenuated monovalent (G1P [8]) human rotavirus vaccine (RV1; Rotarix ® ) was not approved until November 2011, and the pentavalent (G1, G2, G3, G4, and P [8]) human-bovine rotavirus reassortant vaccine (RV5; RotaTeq ® ) was not approved until July 2012. Hence, these are not currently included as routine vaccinations in the Japanese childhood immunization program.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Changes in Rotavirus Genotypes before and after Vaccine Introduction: a Multicenter, Prospective Observational Study in Three Areas of Japan

et al. 2017

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Section: Introductionmentioning

confidence: 73%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Changes in Rotavirus Genotypes before and after Vaccine Introduction: a Multicenter, Prospective Observational Study in Three Areas of Japan

et al. 2017

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“…Like influenza, RVGE is a seasonal disease that mainly occurs in the winter season, with a peak between February and March in Japan (7). Several hospital-based studies have reported on the incidence of RVGE among children aged º5 years; this incidence ranges from a minimum of 3.1 per 1,000 person-years to a maximum of 12.7 per 1,000 person-years (8)(9)(10). These local incidences were extrapolated to determine the annual number of rotavirus-associated hospitalizations, which was estimated to be 26,000-78,000 (8)(9)(10).…”

Section: Introductionmentioning

confidence: 99%

The Burden of Rotavirus Gastroenteritis among Japanese Children during Its Peak Months: an Internet Survey

Nakagomi

Katô

Tsutsumi³

et al. 2013

Jpn J Infect Dis

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SUMMARY: Rotavirus gastroenteritis (RVGE) is one of the most common early childhood diseases; however, little information exists on the frequency of RVGE attacks during peak epidemic months and the subsequent clinical consequences in Japanese children. Therefore, we conducted a nationwide internet survey that targeted mothers whose children recently experienced an episode of RVGE or influenza from January 2011 to April 2011. Data concerning the incidence and clinical consequences of RVGE and influenza among 15,137 children aged º3 years were collected. Of these, 1,286 children who experienced an RVGE episode and 1,487 children who experienced an influenza episode visited a physician or required hospital admission. Data analysis of 867 RVGE episodes and 897 influenza episodes found that 25z of children with RVGE required 8-14 days for recovery, 28z received intravenous rehydration, 7z were hospitalized, 15z visited an emergency department, 70z sought medical interventions AE2 times, and 32z sought medical intervention AE3 times. Compared with influenza, RVGE required a longer recovery period, and was associated with more frequent episodes of intravenous rehydration, hospitalization, and emergency department and physician visits. Our results indicate that, like influenza, RVGE occurring during peak epidemic months in children aged º3 years imposes a substantial burden on families and medical institutions in Japan.

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Modeling seasonal variation in rotavirus hospitalizations for use in evaluating the effect of rotavirus vaccine

Sato

Nakagomi

Naghipour

et al. 2010

Journal of Medical Virology

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Every year rotavirus epidemic repeats in cooler months of the year in temperate countries, but the size of the epidemic may often vary. Such seasonal variation needs to be considered when the effect of rotavirus vaccine is predicted before vaccine introduction or it is evaluated after vaccine introduction. A computer program based on a stochastic decision tree model was developed to produce stochastic variation, which was used as a proxy for seasonal variation, in the number of rotavirus hospitalizations. When the model was applied to a hypothetical community with a birth cohort of 1,000 children in Japan, it predicted the occurrence of up to 29% of stochastic variation from the average number of rotavirus hospitalizations. Then, the model was applied for use in evaluating the effect of rotavirus vaccine in two different scenarios regarding vaccine use in the community: a scenario where rotavirus vaccine was introduced only into the private sector, and another where it was incorporated into the universal immunization program. In the former scenario, an average of 23% reduction in the number of rotavirus hospitalizations was predicted, but this level of reduction would be obscured due to seasonal variation. In the latter scenario, an average of 74% reduction was predicted, which would be beyond seasonal variation. This model will be useful to inform stakeholders and policymakers how vaccine introduction will change the burden of rotavirus disease under different scenarios of vaccine implementation.

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A Retrospective Evaluation of Hospitalizations for Acute Gastroenteritis at 2 Sentinel Hospitals in Central Japan to Estimate the Health Burden of Rotavirus

Abstract: The burden of severe rotavirus disease among Japanese children is substantial and warrants consideration of vaccination as a prevention strategy.

Cited by 30 publications

References 10 publications

Changes in Rotavirus Genotypes before and after Vaccine Introduction: a Multicenter, Prospective Observational Study in Three Areas of Japan

Changes in Rotavirus Genotypes before and after Vaccine Introduction: a Multicenter, Prospective Observational Study in Three Areas of Japan

The Burden of Rotavirus Gastroenteritis among Japanese Children during Its Peak Months: an Internet Survey

Modeling seasonal variation in rotavirus hospitalizations for use in evaluating the effect of rotavirus vaccine

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